Carbonic Anhydrase Inhibitors Flashcards
1
Q
Examples
A
Acetazolamide
2
Q
MoA
A
Carbonic anhydrase enzyme
Inhibitor
Reduces formation of H2CO3 in PCT epithelial cells
Reduces H+ secretion = reduces Na+,Ka+,HCO3- reabsorption
Sodium diuresis and bicarbonate depletion
3
Q
Indications
A
Glaucoma
Altitude sickness
4
Q
ADR
A
Renal Stone Formation Hyponatraemia Hypokalaemia Hypocalcaemia Acidosis