Carbonic Anhydrase Inhibitors Flashcards

1
Q

Examples

A

Acetazolamide

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2
Q

MoA

A

Carbonic anhydrase enzyme
Inhibitor
Reduces formation of H2CO3 in PCT epithelial cells
Reduces H+ secretion = reduces Na+,Ka+,HCO3- reabsorption
Sodium diuresis and bicarbonate depletion

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3
Q

Indications

A

Glaucoma

Altitude sickness

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4
Q

ADR

A
Renal Stone Formation
Hyponatraemia
Hypokalaemia
Hypocalcaemia
Acidosis
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