Nicotinic Drugs

Question 1

What are the two main classifications of Nicotinic Drugs?

Answer 1

Depolarizing blockade (agonists) 
      & 
Nondepolarizing Blockade (competitive antagonists)

Question 2

Succinylcholine

Answer 2

nicotinic agonist (depolarizing blockade) 
- intensely increases activation at nicotinic receptors--> muscle fasiculations (twitch) then desensitize=  paralysis 

use: ST paralysis–> intubation

Question 3

side effects of succinylcholine

Answer 3

1. bradycardia (M2)
2. K+ release (from prolonged depolarization)
3. prolonged paralysis if genetic variants of pseudocholinesterase
4. malignant hypothermia

Question 4

BucheE

Answer 4

pseudocholinesterase - breaks down succinylcholine (nicotinic agonist- depolarizing blockade)

Question 5

D- tubocurarine

Answer 5

nicotinic antagonist

not used, “arrow poisoning” from alkyloid plant

Question 6

Pancuronium

Answer 6

long acting nicotinic antagonist

selective for Nm >Nn Rec. (ganglia)

Question 7

Vecuronium

Answer 7

intermediate duration acting nicotinic antagonist

selectivity: Nm>Nn

Question 8

Mivacurium

Answer 8

short acting nicotinic antagonist

Nm>Nn

Question 9

Uses of Nicotinic Antagonists (competitive)

Answer 9

pralyze skeletal m. for surgery (induce Nm blockade)

Question 10

Side effects of Nicotinic antagonists

Answer 10

hypertension, apnea, bronchospasm, salivation, flushing, resp. failure