Cholinergic Storage and Release Drugs

Question 1

Hemicholinium

Answer 1

prevents Ach reuptake

increased Ach

Question 2

Vesamicol

Answer 2

prevents vesicular storage of Ach–> nothing released

reduced Ach

Question 3

Botulinum Toxin

Answer 3

prevents exocitosis of Ach

reduced Ach

Question 4

Edrophonium

Answer 4

Simple alochol
AchE inhibitor–> increased Ach, ST
diagnosis of MG & LE

Question 5

Neastigmine

Answer 5

AchE inhibitor carbamic acid deriv
LT
treat MG, reverse muscular blockers

Question 6

Physostigmine

Answer 6

AchE inhibitor; carbamic acid deriv
LT
treat MG, Reverse muscular blockers
crosses BBB–> reverse atropine poisoning

Question 7

parathion

Answer 7

organophosphate
warefare, pesticide
irreversible AchE inhibitor

Question 8

rivastigmine

Answer 8

AchE inhibitor–> delay dementia impairment (e.g. AD–> by 6 mo)

Question 9

Negative effects of AchE inhibitors

Answer 9

1) increased muscuarinic stimulation (salivation, miosis, bradycarida, diarrhea)
2) increased nicotinic stimulation (muscle weakness, paralysis)
3) chemical warfare

Question 10

Uses of AchE inhibitors

Answer 10

1. increased parasympathetic tone (reduce intraocoular P–glaucoma)
2. reverse atropine poisining
3. reverse m. paralysis from neuromuscular blockers

Question 11

True or false AChE inhibitors are parasympathomimetics

Answer 11

True

Muscarinic antagonists are parasympathoLYTICS