Nevin Yalman

Question 1

AML subtypes

Answer 1

M0 undifferentiated
M1 aml without differantiation
M2 AML with differentiation
M3 en iyi seyreden, promyelocystic lösemi
M4 myelomonocytic lösemi
M5 monocytic lösemi
M6 erythroleukemia
M7 en kötü seyreden,megakaryocytic lösemi

Question 2

Good prognosis

Answer 2

M4
M6
T(15,17)
Matched sibling transplant

Question 3

Bad prognosis of AML

Answer 3

Wbc >100.000
Secondary
Monosomy 7

Question 4

CML

Answer 4

Philedelphia chromosome,
BCR-ABL fusion protein: P210
Ph+ALL: P190
Phases:
1. Blast: >%30, look like all or aml, extramedullary disease symptoms
2.Accelerated: progressive, splenomegaly
Blasts:10-30, baso+eo>%20
3.chronic: peripheral/ marrow blasts <%10
Thrombocytosis, leukocytosis
Treatment: Gleevac (imatinib) :tyrosine kinase inhibitor that blocks BCR-ABL
Transplant is the choice for peds
Additional chemo if progresses: IFN, Ara-c, hydroxyurea

Question 5

JMML: juvenile myelomonocytic leukemia

Answer 5

Young kids
Assoc with NF1
Lab:High HgbF,hypersensitivity to GM- CSF, monosomy 7, no BCR-ALB, blasts+pros <%20, monocytosis
Like a stem cell leukemia, but acts like: MDS more than leukemia !
Treated with SCT, but very often fatal