Neutropenic Fever and Transfusions Flashcards
empiric regimen for neutropenic fever - combo tx
piperacillin (anti-pseudomonal) and gentamicin/tobramyin (pseudomonocidal aminoglycoside)
empiric regimen for neutropenic fever - monotherapy
4 choices
imipenem
meropenem
cefepime
ceftazidime
if neutropenic fever doesn’t respond to abx after 5 days
think fungus (candida is common)
if neutropenic fever and considering anti-fungal - 3 choices
Ampho B
Caspofungin
Voricon(-azole)
voriconazole covers?
candida lusitaniae
most common host source of neutropenic fever
endogenous flora
5 most common gram + causes of neutropenic fever
- coag neg staph (sapro/epidermidis)
- S aureus/MRSA
- strep pneumo/strep
- corynebacterium
- VRE
4 most common gram - causes of neutropenic fever
- e coli
- klebsiella
- pseudomonas
- enterobacter
most common anaerobic cause of neutropenic fever
c diff
2 most common fungal causes of neutropenic fever
candida
aspergillus
7 common sites of infection in neutropenic pts
- line infections/skin
- heart/endocarditis
- lung
- HEENT/mucous membraness
- brain
- abdomen
- UTI
most common reaction to blood products
febrile non-hemolytic reaction
how to pre-treat febrile non-hemolytic reaction
acetaminophen prior to platelet transfusion
incidence of HIV with transfusion
1 in 2 million
incidence of Hep C with transfusion
1 in 2 million
