Neurotransmitters Info Flashcards
4 sites of acetylcholine
NMJ
Basal ganglia neurons
ANS
Basal Nucelus of Meynert
Basal Nucelus of Meynert function
helps cortex with memory function…plays role in alzheimers when ACh is low here
is glutamate excitatory or inhibitory?
EXCITATORY
Where does glutamate function?
everywhere in the CNS
is GABA excitatory or inhibtory?
inhibitory
where is GABA found?
mainly in interneurons
4 GABA functions
sedation, muscle relaxation, cardiovascular/respiratory function and spinal reflexes
clinical use of GABA
anxiety treatment
is glycine excitatory or inhibitory?
inhibitory
where does glycine function?
interneurons in CNS, mainly spinal cord
glycine clinical use
muscle spasticity
other name for serotonin
5-hydroxytryptamine
3 locations of serotonin
raphe nuclei in brain stem
pineal gland
limbic center
5 functions of serotonin in the limbic center
sleep, pain perception, food intake, mood, temperature
enzyme to make catecholamines
tyrosine hydroxylase
2 locations of norepinephrine
ANS Locus Ceruleus (brainstem)
Role of Locus Ceruleus with NorEPI
projects to cortex mediating arousal, sttention and anxiety
3 locations of dopamine
substantia nigra
brainstem
hypothalamus
role of dopamine in substantia nigra
motor control…cause of parkinsons
role of dopamine in brainstem
reward center…pleasure reinforcement…addiction
High dopamine can cause what mental illness?
schizo
role of dopamine in hypothalamus
leads to release of prolactin from pituitary
ionotropic receptor definition
attached to an ion channel
metabotropic receptor definition
leads to secondary messenger pathways like GPCR
what does adenyly cyclase excite?
cAMP
What does phospholipase C lead to (2)
and what are two molecules it leads to?
increased intracellular calcium
Protein Kinase C
Inositol phosphoglycerol 3 and DAG
what does guanylyl cyclase lead to?
cGMP
What does phospholipase A2 do?
arachidonic acid…metabolize
another name for ionotropic and metabotropic
nicotinic
muscarinic
can glutamate affect ionotropic, metabotropic or both?
BOTH..excitatory
can GABA affect ionotropic, metabotropic or both?
BOTH..inhibitory
can serotonin affect ionotropic, metabotropic or both? and is it inhib or excite?
BOTH…iontropic is excite and metabo is both inhib and excite
can adrenergic affect ionotropic, metabotropic or both?
just metabotropic…can be pre and post synaptic
can dopamine affect ionotropic, metabotropic or both? can it be excite or inhib or both?
only metabotropic…both excite and inhib
NE receptors and are they inhib or excite?
a1 excite
a2 inhib
b1 excite
b2 inhib
serotonin receptors and function
5HT-3…ionotropic excite
5HT1-7…metabotropic…excite and inhib
