Neurotransmitters and neurochemicals Flashcards
what are the parts of the neural pathway
pre-synaptic neuron (axon terminal), neural synapse, synaptic gap, post-synaptic neuron (recpetor site, dendrite)
what are the steps/process of the neural pathway
- The pre-synaptic neurons axon terminals release neurochemicals in the neural synapse 2. the neurotransmitters travel across the synaptic gap 3. the neurotransmitters bind to the specific receptors on the dendrites of the post-synaptic neuron
pre-synaptic neuron
the neuron that releases neurochemicals into the neural synapse
axon terminals
aka terminal buttons, they are the ends of a neuron that release neurochemicals into the neural synpase
synaptic gap
the space between the pre-synaptic neuron and post-synaptic neuron
post-synaptic neuron
the neuron that recieves neurocheimcals from the neural synappse
dendrites
branched extensions of a neuron where recpetor sites are located
recpetor sites
protein molecules on the dendrites of a neuron that recieve neurochemicals
neurochemicals
chemical substances that transmit neural information within the nervous system, how neuronsn communicate with one another
the steps/process of synaptic transmission
- neurochemicals are produced in the axon terminals of the pre-synaptic neuron 2. neurochemicals are releassed from the axon terminals of the presynatptic neuron into the synpatic gap 3. neurochemicals bind to specific nreceptor sites on the dendrites of the post-synaptic neuron 4. neurochemicals affect the post-synaptic neuron, either triggering or inhibiting a response
what are the two types of neurochemicals
neurotransmitters and neuromodulators
neurotransmitters
chemical molecules that have an effect on one or more post-synaptic neuron (localised effect), they enable rapid and short lived communication between two neurons across the neural synapse
what are the two categories neurotransmitters
exictatory and inhibitory
neuromodulators
chemical molecules that have an effect on multiple postsynapctic neurons (widespread modulatory effects as they can influence karge areas of brain tissue), they modulate neural activity more slowly but produce relatively long lasting effects
excitatory neurotransmitters
have an excitatory effect on the postsynaptic neuron, causing it to have a greater liklihood of firing an action potential
inhibitory neurotransmitters
have an inhibitory effect on the postsynaptic neuron, causing to have less liklihood of firing an action potential
two specific neurotransmitters required to know
Glutamine and GABA
Type and effect of glutamine
excitatory neurotransmitter (most abudant) and therefore increases the likelihood of the post-synaptic neuron firing an action potential
type and effect of GABA
inhibitory neurotransmitter and therefore decreases the likelihood of the post-synatptic neuron firing an action potential
glutamine role in functioning
importnat role in learning and memory , it strengthens synaptic connections between neurons that are repeatdely activated during learning, the strong synaptic connections represent memory of learning, enables synaptic plasticity, important role in thought and movement
role in functioning of GABA
prevents overecitation of neurons, reduces anxiety by inhibiting extrectory neural signals that contribute to anxiety, important role in preventing seizures
how to neuromodulators modulate the effects of neurotransmitters
- by changing the responsiveness of receptor sites of a particular neurotransmitter (enhacing excitatory/inhibitory effects) 2. changing the neurotransmitter release pattern of the pre-synaptic neuron
what are the neuromodulators that we need to know
Dopamine and serotonin
what is the effect of dopamine
dopamine can change excitatory and inhibitory effects on the postsynaptic neuron, the effect of dopamine depends on the type of recpetor sites present at the particular brain location
what are the three roles in functioning of dopamine
- coordinating voluntary motor movement
- important role in reward based learning, behaviours that recieve a reward may cause the release of dopamine
- also plays a role in motivation, given its role in reward based learning
how does dopamine play a role in motivation
rewarding behaviours that trigger the release of dopamine have a pleasurable consequence for the person and are therefore more likely to be repeated (to experience the pleasure)
what is a consequence of dopamine
it can be associated with addiction
why is dopamine associated with addiction
addicting behaviours often provide an intensley pleasurable reward to the person, motivating them to repeat the behaviour, whnich consequently contributes to addiction
serotonin effect
has inhibitory effects on the postsynaptic neuron
three roles in functioning of serotonin
- mood reglation and stablisation
-regulating the sleep-wake cycle, including the quality and quantity of sleep and feelings or alertness and wakefulness during the day
-apetite, digestion, arousal and nausea
how do apropriate levels of sertonin in the brain affect mood
the person to experience stable and positive moods, promoting wellbeing.
how to low levels of serotonin in the brain affect mood
low levels are associated with mental disorders including depression, correlation selationship, low levels doesnt cause depression
how do medications relayte to neuromodulators
some medications used to treat depression increase serotonin levels or target serotonin receptors in the brain
what is the sleep-wake cycle
the 24 hour period comprising time spent asleep and time spent awake
differences in neuromodulates and neurotransmitters
- neuromodulators bind to multiple post synaptic synapsis whereas neurotransmitters bind to one or two post synaptic neurons 2. neuromodulators effects cause changes in multiple/widespread neurons whereas neurotransmitters directly effects change in the neuron it binds to 3. neuromodulators creates/modulates a slower and longer lasting response whereas a neurotransmitter creates a shorter/rapid response 4. neuromodulators modulate inhibitory or excitatory functions of neurotransmitters whereas neurotransmitters acts in excitatory or inhibitory role
similarities between neurotransmitters and neuromodulators
both act as neurochemicals in the nervous system, both bind to speciifc receptor sites on the dendrites of the post synaptic neuron, both can lead to change in mental processes and behaviour