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VET243 > Neurotransmitters > Flashcards

Neurotransmitters Flashcards

1
Q

Electrical Synapse

A

electrical signals transfered directly through gap junstions

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2
Q

Chemical Synapse

A

neurotransmitter secreted by 1st neuron binds to receptor on 2nd neuron to open ion channels

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3
Q

Small-molecule neurotransmitter

A

occurs in: presynaptic terminal
enzymes: produced in neuronal cell body
precursor molecules: produced locally
Transport: slow

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4
Q

Peptide neurotransmitter

A

occurs in: neuronal cell body

enzymes: packaged in golgi app
transport: fast

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5
Q

Ionotropic receptors

A

ligand gated

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6
Q

Metabotropic receptors

A

g-protein coupled

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7
Q

Acetylcholine

A

Excitatory, choline + AcCoA, CAT is rate limiting, AChEase removal, nicotinic & muscarinic receptors

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8
Q

Glutamate

A

Excitatory, glutamine, glutaminas is rate-limiting, transporter removal, ionotropic and metabotropic receptors

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9
Q

GABA

A

inhibitory, glutamate, GAD is rate limiting, transporter removal, 2 ionotropic and 1 metabo.

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10
Q

Catecholamines

A

excitatory, tyrosine, tyrosine hydrolyase is rate limiting, transporter, MAO, COMT removal, dopa: metabo, norad: alpha and beta metabo (5), adren.: alpha and beta

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11
Q

Serotonin (5-HT)

A

excitatory, tryptophan, tryptophan hydroxylase, transporter and MAO removal, metabo & iono.

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12
Q

Neuropeptides

A

both, AA, synthesis and transport are rate limiting, protease removal

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13
Q

Nitric Oxide

A

both, arginine, N.O. synth is rate limiting, spont. oxidation remocal

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14
Q

Curare

A

Recep: nicotinic ACh

Clinical Signs: diaphragm para. + weakness of skeletal m.

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15
Q

Organo-phosphates

A

Recep: ACh
Action: ACh build-up -> blocks AChEase
Clinical Signs: fatigue, paralysis, headache, wheezing

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16
Q

Atropine (Belladonna)

A

Recep: M. ACh (m1-5)
Action: opposes vagus n
Clinical Signs: Increase in HR, decrease in bronchial secretions

17
Q

Diazepam

A

Recep: GABA (enhances)

Clinical Signs: sedation

18
Q

Ketamine

A

Recep: NMDA antagonist

Clinical Signs: anesthia, cataleptic state of sensory isolation

19
Q

Xylazine

A

Recep: alpha2 adrenergic

Clinical Signs: decrease in HR

20
Q

Domperidane

A

Recep: D2 & D3 antagonist

Clinical Signs: increase in upper GI motility, increase in lactation, nausea relief

21
Q

SSRIs

A

Action: inhibits serotonin reuptake

Clinical Signs: increases serotonin for post-synp. depression

VET243 (8 decks)

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