neurotransmitters Flashcards
is glutamate inhibitory or excitatory (CNS)
EXCITATORY - meaning it makes sure the pain signal gets to where it needs to go
glutamate binds to
NMDA receptors
what are the NMDA antagonists
ethanol and ketamine
is noradrenaline excitatory or inhibitory in the CNS AND PNS
it can be both depending in the receptor location
what part of pain physiology is noradrenaline involved in
pain modulation
noreadrenaline is described as a feel _____ neurotransmitter
feel good neurotransmitter
what medications block noreadrenaline reuptake which can help manage neuropathic pain
SNRI and TCA
is substance P excitatory or inhibitory in the PNS
excitatory
what is the role of substance p
to mediate nociceptive transmission from the pns to the cns
what secretes substance p
1st order neurons at the dorsal horn
are endorphins and enkephalins excitatory or inhibitory at the cns
generally inhibitory
endorphins and enkephalins are what kind of opioids
endogenous opioids
what encourages the release of endorphins and enkephalins
exercise, pets, laughing, sex, love
what are the two relevant endocannabinoids
2ag and anadamide
are endocannabinoids excitatory or inhibitory on the cns
inhibitory
what is the endocannabinoid system responsible for
homeostatic functions, pain modulation
what receptors does THC bind to
CB1 (CBR1) receptors
is GABA excitatory or inhibitory to the CNS
generally inhibitory
GABA is the ____ inhibitory neurotransmitter for the ____
major inhibitory neurotransmitter for the brain
is glycine excitatory or inhibitory on the CNS
inhibitory
glycine is the _____ inhibitory neurotransmitter in the _______
majory inhibitory neurotransmitter in the spinal cord
is serotonin (5HT) excitatory or inhibitory on the CNS
inhibitory
the medications that block serotonin reuptake that can be used to manage neuropathic pain are
SSRIs
