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biomed 9! > neurotransmitters > Flashcards

neurotransmitters Flashcards

1
Q

is glutamate inhibitory or excitatory (CNS)

A

EXCITATORY - meaning it makes sure the pain signal gets to where it needs to go

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1
Q

glutamate binds to

A

NMDA receptors

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2
Q

what are the NMDA antagonists

A

ethanol and ketamine

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3
Q

is noradrenaline excitatory or inhibitory in the CNS AND PNS

A

it can be both depending in the receptor location

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4
Q

what part of pain physiology is noradrenaline involved in

A

pain modulation

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5
Q

noreadrenaline is described as a feel _____ neurotransmitter

A

feel good neurotransmitter

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6
Q

what medications block noreadrenaline reuptake which can help manage neuropathic pain

A

SNRI and TCA

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7
Q

is substance P excitatory or inhibitory in the PNS

A

excitatory

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8
Q

what is the role of substance p

A

to mediate nociceptive transmission from the pns to the cns

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9
Q

what secretes substance p

A

1st order neurons at the dorsal horn

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10
Q

are endorphins and enkephalins excitatory or inhibitory at the cns

A

generally inhibitory

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11
Q

endorphins and enkephalins are what kind of opioids

A

endogenous opioids

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12
Q

what encourages the release of endorphins and enkephalins

A

exercise, pets, laughing, sex, love

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13
Q

what are the two relevant endocannabinoids

A

2ag and anadamide

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14
Q

are endocannabinoids excitatory or inhibitory on the cns

A

inhibitory

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15
Q

what is the endocannabinoid system responsible for

A

homeostatic functions, pain modulation

16
Q

what receptors does THC bind to

A

CB1 (CBR1) receptors

17
Q

is GABA excitatory or inhibitory to the CNS

A

generally inhibitory

18
Q

GABA is the ____ inhibitory neurotransmitter for the ____

A

major inhibitory neurotransmitter for the brain

19
Q

is glycine excitatory or inhibitory on the CNS

A

inhibitory

20
Q

glycine is the _____ inhibitory neurotransmitter in the _______

A

majory inhibitory neurotransmitter in the spinal cord

21
Q

is serotonin (5HT) excitatory or inhibitory on the CNS

A

inhibitory

22
Q

the medications that block serotonin reuptake that can be used to manage neuropathic pain are

A

SSRIs

biomed 9! (4 decks)

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