Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Cns Bio 1 > Neurotransmitters > Flashcards

Neurotransmitters Flashcards

You may prefer our related Brainscape-certified flashcards:
Biology 101 flashcards
1
Q

NT definition

A

Endogenous substance act as a chemical messenger to communicate the neurons with each other

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

NT stored in

A

Synaptic vesicles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Inactivation of NT by ..and …

A

Re_uptake “most prevalent form”
Hydrolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Glutamate and aspartate is … AA , ….NT and their elevation cause ….

A

Not essential AA
Excitatory NT
Neurotoxicity ,neural death or injury

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Glutamate is ….AA and removal by …..

A

Principal excitatory AA
Re_uptake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

GABA is …AA derived from …AA by ….
Enzyme need … As a coenzyme

A

Principal inhibitory
Glutamate
GAD “glutamic acid decrboxylase”
PLP “vit B6”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Fate of GABA

A

GABA + GABA _Transaninase” need PLP” = succinate semi aldehyde
succinate semi aldehyde +succinate semi aldehyde dehydrogenase= succinate + NADH+H+
Succinate enter the krebs cycle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

GABA deficiency cause ….

A

Seizure and epilepsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

GABA agonist work as ……. Like ….

A

Anti anxiety
Benzodiazepine and Barbiturate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Glycine is ….. NT derived from…
By …. Enzyme and removed by

A

Major inhibitory
Serine
Serine hydroxy methyl transferase
Re_uptake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Ach choline is …NT formed from …. And ….. By … Enzyme
Removal by ….. Enzyme to be ….. And …..

A

Excitatory neurotransmitter
Ach COA and choline
Choline ACh transferase
…..
Ach choline estrase
Acetate and choline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is Myathenia gravis and its treatment?

A

Chronic auto immune disease caused by antibody aganist ACh choline Receptor
Treatment is inhibit ACh choline esterase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Catecholamine formed from ….

A

Tyrosine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

The primary end product in medulla of new born is ….. And in advanced age ….. Is raised depend on …..

A

NE
E
Cortisol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Tyrosine convert to DOPA by …… Enzyme

A

Tyrosine hydroxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The rate limiting enzyme in catecholamine synthases is

A

Tyrosine hydroxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

DOPA converts to Dopamine by … Enzyme need …. Coenzyme

A

Aromatic amino acid decrboxylase
PLP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Dopamine converts to NE by …… And need ……

A

Dopamine B hydroxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

NE converts to E by …… Need ….

A

Phenylethanolamine N methyl transferase
SAM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Fate of catecholamine

A

Major fate is re uptake by sympathetic nerve endings
Catabolism to inactive product by MAO “ oxiditive deamination “
and COMT “methylation”
Dopamine converts to HVA
NE And E convert to VMA

21
Q

mechanism of Parkinson disease ?

A

Insufficient dopamine due to loss of dopamine producing cell

22
Q

How can we detect it

A

⏬HVA in urine

23
Q

Treatment of Parkinson

A

Give L_DOPA with carbidopa “sinemet”

24
Q

Explain why dopamine doesnot take in treatment of Parkinson

A

Because it doesnot cross BBB

25
Q

The benefit of carpidopa in treatment of Parkinson

A

⏬decarboxylase of L_DOPA in peripheral tissue
⏫ Concentration of L_DOPA reached to brain
Not cross BBB

26
Q

Treatment of HTN by ….. And inhibit which enzyme

A

Alpha methyl dopa
Inhibit dopa decarboxylase

27
Q

Mechanism of pheochromocytoma

A

Tumer in chromaffin cell in adrenal medulla

28
Q

Manifestation of it ?

A

HTN and palpitation

29
Q

How can you detect it

A

⏫VMA in urine to 500 mg /day

30
Q

Treatment is ….

A

Alpha methyl tyrosine inhibit tyrosin hydroxylase

31
Q

MAOI is used as….increase level of …. And ….

A

Anti depressant
NE and seritonin

32
Q

Seritonin and melatonin synthesis from …. AA

A

Tryptophan

33
Q

Seritonin produced in CNS by….

A

Argentaffin cells in GIT
Platlet

34
Q

Function of seritonin

A

In cns
act as NT
Involved in mood and appetite and temperature regulation
Source of melatonin in pineal body
Stimulate smooth muscle to contract “ vc”
Important in GIT motility

35
Q

Steps of seritonin synthesis

A

Hydroxylation
Decarboxylation

36
Q

Degradation of seritonin by .. and converted to…

A

MAO
5-HIAA
5hydroxyindolacetic acid

37
Q

Carcinoid tumer is called … In … Cell
Increase in production of …. And … In urine
Decrease production of ….. Caused

A

Argentaffinoma
Argentaffin cells in GIT
Seritonin
5HlAA in urine
Nicotinic acid
Pellagra

38
Q

SSRIs used as ……

A

Antidepressants

39
Q

Melatonin synthesis from …. And their steps…

A

Seritonin
Acetylation and methylation

40
Q

Function of melatonin

A

Stimulation of immune system
Antioxidant
Regulation of sleep pattern
Its formation follow th circadin rhythm
⏫dark ⏬light

41
Q

Melatonin related to age ?

A

⏬with age

42
Q

Melatonin deficiency caused by…..

A

Cigarettes
Caffeine
Stress
Antidepressants
B blocker

43
Q

Histamine come from …. By ….. Need …. Secreted from …

A

Histidine
Histidine decarboxylase
PLP
Mast cell

44
Q

Histamine secreted in …

A

Allergic reaction
Inflammatory reaction
Gastric acid secretion

45
Q

Histamine mediating…

A

Arousal and powerful VD

46
Q

NO come from …. by …. Enzyme which release ….

A

L arginine
Nitric oxide synthase
NADP and L citrulline

47
Q

Function of NO

A

VD in ccm
Relaxation of GIT and urinary tract
Stimulate release of hormones from hypothalamus
Produced by MQ, monocytes, neutrophil to kill the organism

48
Q

Nitroglycerin treat….

A

Angina by lower blood pressure and increase blood supply

49
Q

Inhalation of NO treat

A

Pulmonary hypertension and edema
Without decrease systemic blood pressure

Cns Bio 1 (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions