Neurotransmitters Flashcards
What are the 2 “fast response” type of receptors?
Ion Receptors, G protein coupled receptors
What are the 2 “slow response” type of receptors?
Enzyme linked transmembrane receptors, Intracellular receptors
What are examples of ligand gated ion receptors?
Nicotinic receptors, NMDA, GABA
What kind of receptor do local anesthetics work on?
Voltage-sensItive ion channel
What type of receptor is the most abundant in the body?
G-protein coupled receptors
How does a G-protein coupled receptor work and what are some examples?
The receptor activates or inhibits an enzyme, it uses a second messenger system to work at an effector protein to target the ion channel or a target receptor. Ex: hormones, catecholamines, opioids, anticholinergics, antihistamines
In both the PNS and SNS, you will see _____ interact with a ______ receptor
acetylcholine, nicotinic
What two substances come together to make acetylcholine? What substance is located within the synapse?
AcetylCoA and Choline, choline acetyltransferase
Acetylcholine is stored in ____ until the neuron fires
vesicles
After traveling to the post synaptic membrane, what does acetylcholine break down in to? What is the substance that breaks it down?
Choline and acetate, acetylcholinesterase
What type of receptors are nicotinic receptors? Where are they located?
Ligand gated, neuromuscular junction, autonomic ganglia, and CNS
What are 3 agonists of nicotinic receptors?
Acetylcholine, succinylcholine, nicotine
What type of receptor are muscarinic receptors?
G-protein coupled
What are muscarinic receptors stimulated by? Blocked by?
Stimulated: acetylcholine, muscarine. Blocked: atropine, scopolamine, pilocarpine.
What does stimulation of muscarinic receptors do?
Salivary and sweat gland secretion, pupillary constriction, increased GI peristalsis, slows SA and AV nodes. (parasympathetic effects)
Where is dopamine synthesized?
CNS neurons
Where is Epi and Norepi synthesized?
second-order neurons of the SNS in the adrenal medulla. Norepi also in CNS neurons
How many subgroups are there of muscarinic receptors?
5, M1-M5
What are the two receptors classes of dopamine?
D1-like, D2-like
What subclasses are in D1-like dopamine class? What do they do?
D1, D5. Increase cAMP (by a second messenger system)
What are the subclasses in the D2-like dopamine class? What do they do?
D2, D3, D4, decrease cAMP