Neurotransmission Flashcards

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1
Q

What are the key structures in a neuron?

A
  • dendrites
  • soma
  • axon
  • terminal boutons
  • neuronal membrane
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2
Q

Describe a dendrite

A

The recipient of information from other neurons, have a large receptive field due to their branch like structure

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3
Q

What is the cell soma?

A

The body of the cell which control processing in the cell and integrates information

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4
Q

Describe an axon

A

Carries information (action potentials) from the soma to the terminal boutons connecting to multiple neurons

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5
Q

Describe terminal boutons

A

They are found at the end of the axon, the communication point of a neuron connecting to multiple neurons

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6
Q

What is the neuronal membrane?

A

It separates the extracellular and intracellular environment, allowing certain substances into the cell

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7
Q

What is the membrane potential?

A

The difference in charge from the inside to the outside of the cell, the inside is more negatively charged

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8
Q

Why is there a membrane potential?

A

The force of diffusion - molecules moving from an area of high to low concentration
The force of electrostatic pressure - like charges attract, opposite charges repel

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9
Q

What is the sodium-potassium pump?

A

It maintains the ionic concentration gradients across the membrane, ATP is broken down releasing energy which forces ions to move against their concentration gradient

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10
Q

What is happening when the cell membrane is at rest?

A

More potassium channels are open than sodium channels so more potassium is leaving than there is sodium coming in hence the negative charge

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11
Q

What does the oligodendroglial cell do?

A

form myelin around axons in the brain and spinal cord

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12
Q

What do Schwann cells do?

A

wrap around peripheral nerves to form myelin

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13
Q

What are nodes of ranvier?

A

the ends of myelinated sections on axons

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14
Q

What is myelin and its purpose?

A

a fatty coating which causes action potentials to jump along the axon thus requiring less energy

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15
Q

What is the result of myelin sheath damage?

A

multiple sclerosis; problems with nerve impulses

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16
Q

What is a tetrodotoxin?

A

a toxin which blocks voltage gated Na+ channels leading to paralysis and death

17
Q

What is a dendrotoxin?

A

a toxin which blocks village gated K+ channels leading to intense convulsions

18
Q

How are neurotransmitters released?

A

synaptic vesicle is docked at the synaptic membrane, presynaptic depolarisation opens Ca+ channel, vesicles bind to postsynaptic membrane and release neurotransmitter and then the vesicle detaches

19
Q

Describe the key physical feature os ionotropic receptors and what this achieves

A

doughnut shaped; allows ions to flow through the receptor, protein subunits surround the central pore

20
Q

What is the function of a metabotropic receptor?

A

indirect transmission via a G-coupled protein receptor, amplifies the signal

21
Q

How do G-coupled protein receptors transmit signals?

A

the neurotransmitter binds to the receptor and activates the G-protein, the protein splits and activates other enzymes

22
Q

How are neurotransmitters deactivated?

A

reuptake into the synaptic cleft or by enzymes which break the neurotransmitter down

23
Q

What are the features of Glutamate?

A

it is the major excitatory neurotransmitter in the CNS, activates both ionotropic and metabotropic receptor

24
Q

What are the features of GABA?

A

it is the major inhibitory neurotransmitter in the NCS, activates the ionotropic receptor only

25
Q

What are autoreceptors?

A

receptors which respond to neurotransmitters in the synaptic cleft; act as a negative feedback mechanism

26
Q

What do autoreceptors do?

A

regulate internal processes controlling the synthesis and release of neurotransmitter