Neurotransmission Flashcards

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1
Q

What contains the nudou and metaticar apparitas of the mason?

A

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2
Q

What encases the neuron and is sometimes referred to as the somatic membrane?

A

The cell membrane; on the axon, it is known as the axonal membrane.

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3
Q

What is the role of dendrites?

A

Dendrites receive information from other neurons.

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4
Q

What is the function of the axon?

A

To conduct electrical activity down to the axon terminals.

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5
Q

What is contained in axon terminals, and why is it important?

A

Vesicles filled with neurotransmitter (NT); essential for transmitting signals to other neurons.

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6
Q

What is the difference between myelinated and unmyelinated axons?

A

Myelinated axons conduct signals faster due to the myelin sheath, which enables saltatory conduction.

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7
Q

What do axons form in the PNS and CNS?

A

Axons form nerves in the Peripheral Nervous System (PNS) and tracts in the Central Nervous System (CNS).

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8
Q

Where are ions located in relation to neurons?

A

Ions are located inside cellular membranes (intracellular fluid) or outside cells (extracellular fluid).

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9
Q

What causes the resting potential in neurons?

A

An uneven concentration of ions between the inside and outside of the cell creates a resting potential of -70 mV.

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10
Q

What ions contribute to the resting potential?

A

Potassium (K+), sodium (Na+), chloride (Cl-), and large protein molecules (A-).

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11
Q

How do ions move across the membrane, and what two forces drive this movement?

A

Ions move down their concentration gradient and are influenced by electrostatic pressure.

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12
Q

How do ions move across the membrane, and what forces drive this movement?

A

Ions move down their concentration gradient and are influenced by electrostatic forces, where like charges repel and opposites attract.

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13
Q

What helps maintain the resting potential by regulating ion distribution?

A

The sodium-potassium pump transports Na+ out and K+ into the cell.

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14
Q

What is an action potential?

A

A brief reversal of membrane potential from negative to positive, allowing signal conduction.

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15
Q

At what voltage does a neuron reach the threshold to produce an action potential?

A

-55 millivolts (mV).

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16
Q

What happens to the neuron’s charge during an action potential?

A

The charge briefly reverses, making the inside of the neuron positive compared to the outside.

17
Q

What causes the change in charge during an action potential?

A

Na+ ions enter the cell followed by K+ ions leaving the cell.

18
Q

What is the refractory period in a neuron?

A

A period after an action potential when the neuron cannot fire again until it resets.

19
Q

What is saltatory conduction and what structure enables it?

A

Saltatory conduction is the jumping of action potentials between Nodes of Ranvier, enabled by the myelin sheath.

20
Q

What is synaptic transmission?

A

The process where an action potential leads to neurotransmitter release from the presynaptic neuron to the postsynaptic neuron.

21
Q

How is neurotransmitter released into the synaptic cleft?

A

Vesicles bind with the presynaptic membrane, releasing neurotransmitter into the cleft through exocytosis.

22
Q

The two main types of postsynaptic receptors

A

ionotropic receptors and metabotropic receptors

23
Q

What determines whether a postsynaptic potential is excitatory (EPSP) or inhibitory?

A

Whether the neurotransmitter opens sodium (Na+, excitatory) or chloride (Cl-, inhibitory) channels.

24
Q

How are neurotransmitters removed from the synaptic cleft?

A

By reuptake into the presynaptic neuron or enzymatic degradation.

25
Q

Name an excitatory neurotransmitter and an inhibitory neurotransmitter.

A

Glutamate (excitatory) and GABA (inhibitory).

26
Q

Which disease is associated with reduced levels of acetylcholine and specific brain pathologies?

A

Alzheimer’s Disease.

27
Q

Which neurotransmitter imbalance is related to depression?

A

Abnormalities in cholinergic, catecholaminergic, and serotonergic transmission.

28
Q

Which disorder involves demyelination of axons, leading to delayed or blocked signals?

A

Multiple Sclerosis.

29
Q

What causes Parkinson’s Disease on a cellular level?

A

Loss of dopaminergic neurons in the substantia nigra, leading to dopamine imbalance.