Neurotrabsmiters And Pharmacology

Question 1

What are the 3 stages of synaptic transmission?

Answer 1

1. Biosynthesis, packaging and release of NT
2. Receptor action
3. Inactivation

Question 2

What does Alpha latrotoxin do?

Answer 2

Massive NT release —> muscle spasm

Question 3

What does Botulinum toxin do?

Answer 3

Prevent NT release —> paralysis

Question 4

What kind of response to ion channel-linked receptors have?

Answer 4

Fast response

Question 5

What kind of response to G-protein-coupled receptors have?

Answer 5

Slow response

Question 6

What activates ion channel-linked receptors?

Answer 6

CNS: glutamate, GABA

NMJ: ACh at nicotine receptors

Question 7

What activates G-protein-coupled receptors ?

Answer 7

CNS and PNS: ACh at muscarinic receptors, dopamine, noradrenaline, serotonin, neuropeptides

Question 8

What type of receptors do most glutamate synapses have?

Answer 8

AMPA

NMDA

Require co-agonist glycine

Question 9

Which of Gly synapse and GABA synapse is excitatory and which is inhibitory?

Answer 9

Glu —> excitatory

GABA —> inhibitory

Question 10

How is GABA synthesised?

Answer 10

Decarboxylation of glutamate by glutamic acid decraboxylase

Question 11

What are seizures associated with?

Answer 11

Excess glutamate

Question 12

What is the drug target for diazepam?

Answer 12

GABA receptor (alpha subunit) in post synaptic neurone in temporal lobe

Question 13

How does diazepam help treat seizures?

Answer 13

Binds to GABA and increases effectiveness of GABA activation

Question 14

What does Lamotrigine target?

Answer 14

Voltage gated sodium channel

Question 15

What does Pregablin target?

Answer 15

Voltage gated calcium channel