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MSK Personal > Neurotoxins > Flashcards

Neurotoxins Flashcards

1
Q

Bacillus anthracis

A

Toxin 2A + B required for binding to receptor
Edema Factor A causes edema via adenylate cyclase
Lethal Factor A causes pulmonary edema via protease

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2
Q

Bordatella Pertussis

A

Adenylate Cyclase Toxin AB inhibits and kills white cells via adenylate cyclase
Pertussis Toxin AB5 has many hormonal effects via ADP ribosylation of Gi protein
Tracheal cytoxin kills cilia bearing cells

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3
Q

Clostridium Botulinum

A

Botulinum Toxin AB causes flaccid paralysis by inhibiting synatic vesicle fusion at the neuromuscular junction

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4
Q

Clostridium Difficile

A

Enterotoxin causes hemorrhagic diarrhea by acting at membrane
Toxin A and Toxin B causes cells to lose filaments via deamidation of Rho GTPase

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5
Q

Clostridium Spp.

A

a-toxin causes necrosis in gas gangrene via phospholipase c
b-toxin causes necrotic enteritis
Enterotoxin causes food poising and diarrhea by damaging membranes

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6
Q

Clostridium tetani

A

Tetanus toxin AB is a neurotoxin that inhibits synaptic vesicle fusion at inhibitor synapses leading to spastic paralysis

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7
Q

Corynbacterium diphtheriae

A

Diptheria toxin AB kills cells by ribosylating EF2

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8
Q

Escherescia Coli

A

Heat-labile enterotoxin AB5 causes diarrhea identical to cholera toxin
Cytotoxin causes hemorrhagic colitis
Heat-stabe enterotoxin causes diarrhea by activating guanlyl cyclase

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9
Q

Legionella pneumophila

A

Cytotoxin lyses cells

Type IV cytotoxins inhibit endosome maturation which interfere with Rab protein function

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10
Q

Literia monocytogenes

A

Listeriolysin causes membrane damage

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11
Q

Pseudomonas aeruginosa

A

Exotoxin A kills cells like diptheria toxin

Type III cytotoxins modulate host cell physiology and inhibit the actin cytoskelton

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12
Q

Salmonella

A

Type III cytotoxins modulate host cell physiology by inhibiting the actin cytoskeleton

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13
Q

Shigella dysenteria

A

Shiga toxin kills cells by inactivating ribosomes

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14
Q

Staphylococcus Aureus

A

a-toxin causes hemolytic, leukocytic paralysis of smooth muscle by forming pores
b-toxin causes cytolysis via sphingomyelinase
D-lysin is cytolytic via a detergent action

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15
Q

Superantigens

A

Enterotoxins cause food poisoning by activating host antibody and causeing cytokine synthesis via an antigen independent mechanism
TSST causes fever, headache, arthralgia, neutropenia, and rash via the same
Exfoliating toxin causes sloughing of the skin via protease against desmoglein

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16
Q

Streptococcus pneumonia

A

pneumolysin causes cytolysis

17
Q

Streptococcus pyogenes

A

Streptolysin O is a pore forming toxin

Erythrogenic toxin causes fever, neutropenia, and scarlet fever which is mediated through IL-1 activation of Bcells

18
Q

Vibrio cholerae

A

Cholera Toxin AB5 causes Diarrhea via activation of adenylyl cyclase

MSK Personal (12 decks)

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