Neuroscience- MS Patient Demonstration

Question 1

Define multiple sclerosis.

Answer 1

A chronic inflammatory disease of the
central nervous system of unknown cause
causing oligodendroglial and axonal
pathology

Question 2

Describe the onset and symptoms of multiple sclerosis.

Answer 2

– Usually presents in young adults aged 20-40 years
– Can involve any neurological function – most commonly sensory, motor
and visual symptoms

Question 3

Describe the clinical course of secondary progressive MS

Answer 3

MS typically begins as relapsing-remitting disorder, evolves into
progressive course

Question 4

How is MS diagnosed?

Answer 4

– Primarily based on clinical history
– Supported by magnetic resonance imaging (MRI) and cerebrospinal
fluid (CSF) analysis showing inflammatory abnormalities

Question 5

Describe the pathophysiology of MS

Answer 5

– Cause unknown

– Inflammation and loss of myelin in the CNS

Question 6

Describe the therapy of MS

Answer 6

• Immuno-modulatory and immuno-suppressive treatments (introduced in
  the 1990’s) reduce relapses.
• Effect on long-term evolution and on
  progressive MS remains unclear.