Neuroscience and Perception Flashcards
Requirements for neurotransmitters to bind?
The binding of neurotransmitters to receptors is specific
- Lock and key
Types of Neurotransmitters
Acetylcholine
Dopamine
Serotonin
Acetylcholine
Important transmitter between motor neurons and voluntary muscles
Dopamine
Regulates motor behavior, motivation, pleasure, and emotional arousal
Degeneration of which neurotransmitter is linked to Parkinson’s?
Dopamine
Serotonin
Plays a primary role in regulating sleep, wakefulness, and eating behavior
Copycats of Neurotransmitters
Agonist
Antagonist
Neurotransmitter: Agonist
Chemical that enhances or mimics the action of a neurotransmitter
Neurotransmitter: Antagonist
Chemical that blocks the action of a neurotransmitter
What is an example of an antagonist?
Botox or Botulinum toxin is an Ach antagonist
How do we study the brain?
Patients
Neuroimaging
Neuroimaging
Neuroimaging can be structural (what does the brain look like?) or functional (where are different types of information processed in the brain?)
What techniques for neuroimaging are there?
PET
fMRI
CT
MEG
What do all neuroimaging techniques rely on?
All techniques rely on measuring a specific type of activity (blood flow, neurotransmitter release, electrical impulse) as a proxy for neural activity itself.
Issues with neuroimaging methods
Spatial Resolution
Temporal Resolution
Invasiveness
Cost
Neuroimaging: Spatial Resolution
How close is physical proximity you can get to the target brain area
Neuroimaging: Temporal Resolution
How close in time you can get to when the neurons fire
Neuroimaging: Invasiveness
The extent to which foreign substances are introduced into the body
Neuroimaging: Cost
Most imaging techniques are rather expensive
Neuroimaging: PET, what does it stand for and how does it work?
- Positron Emission Tomography
- PET records the energy from radioactive particles bumping into the regular electrons that are in your brain. Recording more PET signals tells us that more blood flow is traveling to that region.
Compares regional cerebral blood flow between cognitive states (experimental conditions)
Neuroimaging: MRI, what does it stand for and how does it work?
- Magnetic resonance imaging
- Uses a powerful magnetic field to produce high-quality images of the brain and its structure
Neuroimaging: fMRI, what does it stand for and how does it work?
- Functional Magnetic Resonance Imaging
- Used to examine changes in ongoing brain activity (function) by measuring changes in the blood’s oxygen levels
fMRI pros and cons
Pros:
- Good spatial resolution allows for precise localization of brain activation
- Non-invasive (no known harm to subjects)
- MRI scanners are widely available at medical centers and research universities
Cons:
- Although temporal resolution (1-4 sec) is much better than PET scans, still much slower than measuring actual activity
- Very expensive
- Scanner noise is very loud
Neuroimaging: EEG, what does it stand for and how does it work?
Electroencephalography (EEG)
- EEG can record electrical activity from large populations of simultaneously active neurons at the scalp with millisecond resolution
- EEF is a direct measure of neural activity
- EEG has good temporal resolution but poor spatial resolution
EEG Limitations
- Limited spatial resolution, despite high temporal resolution
- Skull and brain tissue distort electrical fields
- Largely blind to subcortical activity (too deep to measure on the scalp)
Neuroimaging: TMS, what does it stand for and how does it work?
- Transcranial magnetic stimulation
- Strong magnets are used to briefly interrupt normal brain activity as a way to study brain regions
- Used for:
- Direct testing of function
- Treatment for some neurological and psychological conditions