Neuroscience Flashcards
3 Most Important Parts of life?
Metabolism
Homeosthasis
Organisation
The nervous system came from which layer?
Ectoderm (the same as skin)
Three primary germ layer
- Ectoderm
- Mesoderm
- Endoderm
Glutamate
Glutamate is involved in most brain functions, including cognition, memory and learning. Scientists discovered it as an abundant chemical in the brain over 70 years ago, but only recently identified it as a neurotransmitter. Glutamate is stored in small sacs in neurons (nerve cells) and remains inactive until a nerve impulse triggers its release.
GABA
GABA (gamma-aminobutyric acid) is an inhibitory neurotransmitter that is very widely distributed in the neurons of the cortex. GABA contributes to motor control, vision, and many other cortical functions. It also regulates anxiety.
Some drugs that increase the level of GABA in the brain are used to treat epilepsy and to calm the trembling of people suffering from Huntington’s disease.
Acetylcholine
Acetylcholine is a very widely distributed excitatory neurotransmitter that triggers muscle contraction and stimulates the excretion of certain hormones. In the central nervous system, it is involved in wakefulness, attentiveness, anger, aggression, sexuality, and thirst, among other things.
Alzheimer’s disease is associated with a lack of acetylcholine in certain regions of the brain.
Dopamine
Dopamine is a neurotransmitter involved in controlling movement and posture. It also modulates mood and plays a central role in positive reinforcement and dependency.
The loss of dopamine in certain parts of the brain causes the muscle rigidity typical of Parkinson’s disease.
Serotonin
Serotonin contributes to various functions, such as regulating body temperature, sleep, mood, appetite, and pain.
Depression, suicide, impulsive behaviour, and agressiveness all appear to involve certain imbalances in serotonin.
Norepinephrine
Norepinephrine is a neurotransmitter that is important for attentiveness, emotions, sleeping, dreaming, and learning. Norepinephrine is also released as a hormone into the blood, where it causes blood vessels to contract and heart rate to increase.
Norepinephrine plays a role in mood disorders such as manic depression.
The main anatomical terms for directions
Anterior vs. posterior (front vs back)
Superior vs. inferior (top vs bottom)
Lateral vs. Medial (outside vs middle)
Cortical vs. subcortical
The three brains theory
The triune brain consists of the reptilian complex, the paleomammalian complex (limbic system), and the neomammalian complex (neocortex), viewed as structures sequentially added to the forebrain in the course of evolution. However, this hypothesis is no longer espoused by the majority of comparative neuroscientists in the post-2000 era.
White vs Grey Mater
Grey matter, which has a pinkish-grey color in the living brain, contains the cell bodies, dendrites and axon terminals of neurons, so it is where all synapses are. White matter is made of axons connecting different parts of grey matter to each other.
The oldest association between damage to brain and cognitive deficits was around…?
Around 5,000 years ago
Emmanuel Swedenborg (1688-1772)
In his medical writing postulates cerebral localisation of physical and mental functions (one of the earliest people to come up with localisation):
Motor functions in the centrolateral area
Intellect in the frontal regions
Franz Josef Gall (1758-1828):
cranioscopy & phrenology
1. Human mental capacity consists of different separable functions 2. The functions can be localised in specific parts of the brain 3. The use of a function increases the size of specific brain region 4. The growth of a brain regions leads to development of detectable lumps in the skull
Pierre Paul Broca
1824-1880
Broca’s area is a region in the frontal lobe of the dominant hemisphere, usually the left, of the hominid brain with functions linked to speech production. Language processing has been linked to Broca’s area since Pierre Paul Broca reported impairments in two patients.
Limitations of fMRI
Indirect measure of neuronal activity
Neuronal activity can reflect activation as well as inhibition
An activation does not mean that a region:
Is dedicated to the function
Is necessary for the function
The lack of activation can mean (among others):
Subliminal activation
Permanent activation
Individual variation
MEG
Magnetoencephalography (MEG) is a functional neuroimaging technique for mapping brain activity by recording magnetic fields produced by electrical currents occurring naturally in the brain, using very sensitive magnetometers.
TMS
Transcranial magnetic stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate nerve cells in the brain to improve symptoms of depression. TMS is typically used when other depression treatments haven’t been effective.
Mirror Neurons
Discovered originally in monkeys
By Giacomo Rizzolatti in Parma
Different localisation: frontal and parietal lobes
React to goal-oriented movement
Impaired perception of ______ emotion is associated with amygdala damage
Fear
Impaired perception of ______ emotion is associated with Basal Ganglia & Insula damage
Disgust
Impaired perception of ______ emotion is associated with Ventral Striatum damage
Anger
Advantages of Functional Neuroimaging
In-vivo study of brain function in normal controls Tasks can be controlled for = experimental design Brings in a lot of money (grants, media attention etc.)