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Psychiatry > Neuropsychopharm Mood Stabilizers > Flashcards

Neuropsychopharm Mood Stabilizers Flashcards

1
Q

What are the primary mood stabilizers?

A

Lithium and Valproate

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2
Q

What are the common side effects of lithium?

A

Polydypsia/polyuria, sedation, tremor

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3
Q

What are the dangerous side effects of lithium?

A

Renal impairment, nephrogenic DI, thyroid dysfunction

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4
Q

What are signs of lithium levels being too high?

A

Coarse tremor, N/V/D, ataxia, AMS, renal failure, convulsions, coma

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5
Q

What is the therapeutic window for lithium?

A

0.7 - 1.2

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6
Q

What labs need to be followed in patients on lithium?

A

Lithium levelsBUN/Cr (for renal impairment)T4/TSH (for thyroid dysfunction)

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7
Q

What types of drugs have interactions with lithium?

A

Diuretics, NSAIDs

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8
Q

What are common side effects of valproate?

A

Sedation, weight gain, alopecia

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9
Q

What are dangerous side effects of valproate?

A

Thrombocytopenia, pancreatitis, hepatotoxicity(Also many drug interactions)

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10
Q

What labs need to be followed in patients on valproate?

A

Valpraote levelsPlatelets (thrombocytopenia)LFTs (hepatotoxicity, pancreatitis)

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11
Q

What are signs of valproate toxicity?

A

Nystagmus, N/V, ataxia, lethargy, coma

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12
Q

What psychiatric medication is associated with neural tube defects?

A

Valproate

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13
Q

What are 3 secondary mood stabilizers?

A

Carbamazepine (Tegretol) / Oxcarbamazepine (Trileptal)Lamotrigine (Lamictal)Topiramate (Topamax)

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14
Q

What secondary mood stabilizer has best evidence for use?

A

Carbamazepine (Tegretol) / Oxcarbamezepine (Trileptal)

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15
Q

What are dangerous side effects of carbamazepine?

A

Bone marrow suppression, SIADHAlso many drug interactions

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16
Q

In what patients is lithium CI in?

A

Renal disease

17
Q

What is the role of lamotrigine in bipolar disorder?

A

Used to prevent episodes, not useful during acute episode

18
Q

What are the dangerous side effects of lamotrigine?

A

SJS

19
Q

What secondary mood stabilizer does not actually have evidence for efficacy?

A

Topiramate (Topamax)

20
Q

What are the side effects of topiramate?

A

“Dopamax” (somnolence, depression, cognitive effects)Kidney stones

21
Q

What can topiramate be used for?

A
  1. Secondary mood stabilizer (but not evidence for efficacy)2. Weight loss3. Headaches4. Impulse control in borderline PDAnd, of course, epilepsy treatment.

Psychiatry (9 decks)

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