Neuropsych Flashcards
Achromatopsia
Condition characterized by a partial or total absence of color vision
Agnosia
Inability to interpret sensations or recognize things, typically as a result of brain damage
Agranulocytosis
A severe and dangerous leukopenia (lowered blood cell count)
Akathisia
Extreme motor restlessness
An extrapyramidal side effect of neuroleptic drugs and a symptom of Parkinson’s disease
Akinesia
Loss or impairment of the power of voluntary movement
Anomia
A form of aphasia in which the patient has the inability to name a common or familiar object, attribute, or event
Anosognosia
Inability to recognize one’s own neurological symptoms or other disorder
o Damage to the parietal lobe
Anticholinergic Effects
Includes dry mouth, blurred vision, tachycardia (rapid heart rate), urinary retention, constipation, memory impairment, and confusion
o Caused by several drugs including antipsychotics and TCAs
Aphasia
Impairments in the production and/or comprehension of language as a result of brain damage
Broca’s Aphasia
Difficulty in producing written or spoken language with little or no trouble in understanding language
frontal lobe
Wernicke’s Aphasia
Inability to comprehend written or spoken language with production of rapid speech that is lacking content
temporal lobe
“You know that smoodle pinkered and that I want to get him round and take care of him like you want before.”
Conduction Aphasia
Does not affect language comprehension but does result in anomia, paraphasia, and impaired repetition
parietal lobe
Apraxia
Inability to perform skilled motor movements in the absence of impaired motor functioning
o Damage to the parietal lobe
Asomatognosia
loss of recognition or awareness of part of the body
Ataxia
Characterized by slurred speech, severe tremors, and a loss of balance
o Damage to the cerebellum
Dysprosody
Refers to a disorder in which one lacks normal intonation, stress, and rhythm
o May manifest as pseudo-foreign accent syndrome
Gerstmann’s Syndrome
the loss of the ability to express thoughts in writing (agraphia, dysgraphia), to perform simple arithmetic problems (acalculia), to recognize or indicate one’s own or another’s fingers (finger agnosia), and to distinguish between the right and left sides of one’s body.
o Damage to the parietal lobe
Nueroleptic Malignant Syndrome (NMS)
Rare but potentially fatal side effect of antipsychotic drugs. Involves rapid onset of motor, mental, and autonomic symptoms, such as muscle rigidity, tachycardia, hyperthermia, and altered consciousness
o Drug must be stopped as soon as symptoms develop to avoid fatal outcome
Paresthesia
Pins and needles sensation
o Causes aren’t due to an underlying disease
Tardive Dyskinesia
Potentially irreversible extrapyramidal side effect associated with long-term use of traditional antipsychotic drugs.
o Symptoms: Rhythmical, stereotyped movements of the face, limbs, and trunk
o Some cases symptoms are alleviated by GABA agonist or by gradual withdrawal of the drug
o More common in females and older patients
o Symptoms eventually improve when the drug is gradually withdrawn, although there may be an initial worsening of symptoms
Prosopagnosia
Inability to recognize familiar faces
o Damage to the occipital lobe
Synesthsia
“Joining Senses”
o A rare condition in which the stimulation of one sensory modality triggers a sensation in another sensory modality
E.g. hear a color or taste a shape
Visual Agnosia
Inability to recognize familiar objects
o Damage to the occipital lobe
Acetylcholine (ACh)
Associated with normal aging and Alzheimer’s related declines
o Involved in REM sleep and the regulation of the sleep-wake cycle
Dopamine
Involved in mood, motivation, and voluntary movement (three Ms)
What disorders are related to dopamine?
Parkinson’s disorder = Degeneration of dopamine receptors in the substantia nigra/nearby areas
Tourette’s disorder = Oversensitivity to or excessive dopamine in the caudate nucleus
Dopamine Hypothesis: Plays a key role in schizophrenia—Oversensitivity to or higher levels of dopamine
What drugs are related to an increase of dopamine?
Cocaine, amphetamines, alcohol, and stimulants elevate mood by increasing dopamine
Norepinephrine
Important role in mood, attention, dreaming, learning, and certain autonomic functions
Catecholamine hypothesis: Predicts some forms of depression are due to lower-than-normal levels
Serotonin
Mediates temperature, hunger, and thirst, sexual behavior, aggression, arousal, sleep, and migraine headaches
Decreased levels = Bulimia
Increased levels = Anorexia Nervosa
GABA
o Always inhibitory/reduces activity
o Low levels = anxiety
Benzodiazepines reduce anxiety by enhancing effects of GABA
Abnormal levels of GABA are associated with what disorders?
Huntington’s disease, Parkinson’s disease, epilepsy, and sleep disorders
Glutamate
o Major excitatory neurotransmitter
o Plays a role in long-term potentiation (LTP)—Responsible for the formation of long-term memories
What is the result of excessive levels of glutamate?
Excitotoxicity: Damages or destroys nerve cells
Endorphins
o Analgesic properties: Responsible for pain relief produced by acupuncture
o Implicated in certain pleasurable experiences, emotions, memory and learning, and sexual behavior
What disorders are associated with serotonin?
Depression, mania, OCD, social phobia, schizophrenia, and EDs
What are the three brain divisions?
hindbrain, midbrain, and forebrain
Of the hindbrain, the __ regulates automatic responses such as breathing and HR, whereas the __ coordinates voluntary movements, is responsible for balance and posture, and plays a role in motor skills
medulla; cerebellum
Abnormalities of the cerebellum can lead to what disorders?
autism, schizophrenia, and ADHD
What are the five groups of the spinal cord?
Cervical, thoracic, lumbar, sacral, and coccygeal
Difference between quadriplegic and paraplegic?
o Paraplegia: Damage at the thoracic level; A loss of sensory and voluntary functioning in the legs
o Quadriplegia: Damage at the cervical level; Involves a loss of sensory and voluntary functioning in the arms and legs
somatic nervous system
Carried signals from the skeletal muscles and sense to the CNS and from the CNS to the skeletal muscles
Associated with activities that are considered voluntary
Autonomic Nervous System
Controls glands and muscles of the internal organs, associated with involuntary (automatic) activities
sympathetic and parasympathetic
Sympathetic nervous system
flight or fight reaction
Parasympathetic nervous system
relaxation and energy conservation
Meditation, hypnosis, biofeedback, and other techniques are used to foster the “relaxation response” by activating this branch
Of the midbrain, __ is involved in respiration, coughing, vomiting, posture, locomotion and REM sleep.
reticular formation
Reticular activating system
Plays a role in arousal and consciousness
o Includes the ascending reticular activating system (ARAS)—Involved in selective attention and arousal
o Damage disrupts the sleep-wake cycle and can produce a permanent coma-like state of sleep.
Structures of forebrain
thalamus, hypothalamus, basal ganglia, limbic system
Thalamus
Integrates information from all of the senses except olfaction and relays it to the cerebral cortex
Hypothalamus
Responsible for maintaining the body’s homeostasis through its influence on the ANS and endocrine glands
o Generates physiological reactions associated with rage, fear, and other strong emotions
o Controls the release of hormones from the pituitary and other endocrine glands
o Suprachiasmatic Nucleus (SCN): Controls the body’s circadian rhythms including the sleep/wake cycle and normal daily fluctuations
Basal ganglia
Caudate nucleus, putamen, globus pallidus
Control of voluntary movement
Damage can cause akinesia and hypokinesia
Parkinson’s, Huntington’s, Tourette’s, OCD, and ADHD
Limbic system
amygdala, hippocampus, cingulate cortex