Neuroplasticity

Question 1

What is the difference between learning and retention?

If a rat hears a radio playing “ABCDEFGHIJKLMNOPQ”, what will the mouse learn and retain if it has a) too little neurogenesis, b) too much neurogenesis, c) ‘trade-off’ neurogenesis?

Answer 1

Too little: learned “ABC”, retained “ABC”

Too much: learned “ABCDEFGHIJKL”, retained “KL”

“trade-off”: learned “ABCDEF”, retained “BCDEF”

Question 2

True/False? Licking and grooming variation is maintained across litters.

What are the effects of a pup receiving decreased Licking and Grooming?

Answer 2

True

Decreased L&G: higher corticosterone, lower grains(?), higher immobile time during swim test, higher % potentiation of fEPSP slope

Question 3

What was found in susceptible mice? What does this correlate with?

Answer 3

higher density of CA1 negative memory engram cells

Correlated with Depression-related behaviour

Question 4

What was found in stressed mice?

Answer 4

Lower density of dentate gyrus negative memory engram cells

Question 5

What happens when negative memory engrams are inactivated?

Answer 5

Social avoidance is suppressed

Question 6

What feature do Syt3 KO mice no longer have and what is the effect of this during a swim escape test?

Answer 6

They lack LTD, and cannot forget the location of an escape position after it has changed