Neuroplasticity 1-3 Flashcards

1
Q

at birth - neural circuits

A

Rough draft of neural circuits - genetically determined

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2
Q

after birth - neural circuits

A

neural circuitry is refined by experience - experience dependent reorganzation

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3
Q

Experience dependent reorganization

A

Based on the experience that the brain gets

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4
Q

when does plasticity occur in response to experience

A

continues throughout life

particularly heightened during critical periods

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5
Q

Orphan study

A

Neurocognitive dysfunction is evident in children under social deprivation in orphanages
Longer they stay in orphanage, the higher the incidence of cog impairment

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6
Q

Orphan study - what part of the brain was it noticeable in

A

Uncinate fasciculus - not as developed in the socially deprived child

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7
Q

visual cortex receives information from

A

both eyes

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8
Q

Ocular dominance columns

A

certain areas only receive either left or right eye input
First step of visual perception - crucial that they are separated in this layer and then become integrated in another layer (because of experience)

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9
Q

Ocular dominance - when are the columns developed by

A

6 weeks

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10
Q

Merzenich - monkeys with sutured fingers together

A

inputs of 2 fingers always coming into the cortex together - abolishes the sharp zones of the map

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11
Q

Syndactyly

A

congenital fusion of the fingers - cortical map of the hand is reduced overall - representation of the fingers is not organized somatotopically

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12
Q

Phantom limb sensation -

A

scar of nervous tissue in strump caused the pain - reorganization of cortical circuits
Remapping occurs - face

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13
Q

Musicians and age started

A

The earlier they started to play, the more cortical response you see

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14
Q

Does the type of experience or activity determine the type of plasticity

A

YES

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15
Q

Complex environment paradigm - Rat study

A

EC rats superior performance in running mazes - also they had heavier and thicker cerebral cortices - more synapses - more dendrites

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16
Q

Complex environment paradigm - Rat study - EC rats synaptogenesis compared to IC and SC rats

A

More dendrites, more synapses per neuron in a number of brain areas
New syanpses persisted beyond exposure to EC
Saw synaptogenesis in older rats
Moved EC to IC and still saw new synapses

17
Q

EC rats - was synaptogenesis due to learning or just more general activity - study that answered this question

A

Acrobatic rats/motor learning vs. Free exercises (treadmill)
ML rats - more synapses
FE rats - more angiogenesis

18
Q

Glial changes with motor learning rats and free exercise rats

A

EC had greater number and size of glia, enhanced synaptic function (reuptake NT, cleaning up debris)

19
Q

Take away from motor learning rats vs. free exercise rats

A

Task specificity
We want to do both inc synapses but angiogenesis is good too because it produces a better environment for the neuron
Both important - but just know why it is important to do what you are doing - know your goal

20
Q

Concept of LTP and LTD

A

Synapses that fire together, stay together

21
Q

LTP occurs in synapses that

A

are already active AND in silent synapses

22
Q

NMDA and AMPA are what type of receptors

A

glutamate

23
Q

NMDA or AMPA - which is normally activated

A

AMPA - leads glutamate to come in and it may or may not bring to threshold

24
Q

NMDA or AMPA - which is not normally activated

A

NMDA - activated with high frequency - presynaptic cell is discharging a lot of glutamate

25
Q

LTP is the cascade of responses involving

A

AMPA and glutamate

It impacts presynaptic efficiency AND post synaptic

26
Q

LTP cascade - what happens to dendrite head

A

it grows to make room for all of the AMPA - gets to threshold and then dendrite breaks off and you have two heads now - more easily brought to threshold now

27
Q

LTD is what

A

taking AMPA receptors down

Its a balance - this down regulates the system