NEUROPHYSIOLOGY Flashcards
produces CSF
ependymal cells
more numerous: neurons or glial cells?
Glial cells 10:1 ratio
macrophage of the brain
microglia
regulate ECF ion levels, provide mechanical support, part of BBB
Astrocyte
creates myelin in the CNS
oligodendrocytes
creates myelin in the PNS
Schwann cells
brain tumors from non-mature neurons
neuroblastoma
retinoblastoma
receiving portion of the neuron
dendrites, cell body
where action potential is initiated
axon hillock
function of myelin sheath
insulator
unmyelinated portions if the axon
nodes of ranvier
branches of the axons
neural fibrils
terminal portion of a neural fibril that contains NT containing vesicles
axon terminal boutons or end feet
space between two neurons
synapse
Which proteins are responsible for anterograde and retrograde transport
anterograde: kinesin
retrograde: dynein
Diseases utilizing retrograde axonal transport
tetanus
botulism
What do you call the death of axon distal to the site of injury after an axon is transected
Anterograde/orthograde degeneration
What do you call the changes to the soma after an axon is transected?
axonal reaction or chromatolysis
Axonal regeneration occurs better in the CNS or PNS?
PNS
where is dopamine found?
substantia nigra pars compacta
ventral tegmental area
dopamine deficiency
Parkinsons disease
Dopamine excess
Schizophrenia
Where is norepinephrine secreted
Locus ceruleus in the pons
iLOCUs NORte
LOCUS ceruleus=NORepinephrine
produce by adrenal medulla
epinephrine
Where is serotonin secreted?
median raphe of the brain stem
histamine location
tuberomamillary nucleus of the hypothalamus
glycine location
increases chloride influx
spinal interneurons
the number 1 INHIBITORY neurotransmitter in the brain
comes from GLUTAMATE
GABA
increases chloride influx
GABA A
increases potassium efflux
GABA B
inhibits nerons in the brain involved in the perception of pain
enkephalins
endorphins
dynorphins
involved in pain transmission
substance P
neurotransmitter deficient in Alzheimers dse
Acetylcholine
making the membrane potential less negative
depolarization
making the membrane potential more negative
hyperpolarization
positive charges flowing into the cell
inward current
positive charges flowing out of the cell
outward current
membrane potential in which occurence of AP is inevitable
Threshold
portion of the AP where membrane potential is positive
overshoot
portion of the AP where membrane potential is more negative than RMP
undershoot/hyperpolarizing afterpotential
period in which New AP cannot be elicited
refractory period
Give examples of sodium channel blockers of neurons
teradoxin
saxitoxin
Give an example of potassium channel blocker of neurons
tetraethylammonium
What stimulates nerve depolarization in the 1st place
mechanical disturbance
chemicals electricity
synaptic inputs that depolarize the post synaptic cell
excitatory post-synaptic potential (EPSP)
synaptic inputs that hyperpolarize the post synaptic cell
Inhibitory post synptic potential(IPSP)
two or more pre synaptic inputs arrive at post synaptic cell simultaneously
spatial summation
two or more presynaptic inputs arrive at post synaptic cell simultaneously
spatial summation
two or more presynaptic inputs arrive at post synaptic cell in rapid succession
temporal summation
repeAted stimulation causes response of post synaptic cell in rapid succession
temporal summation
repeated stimulation causes response of postsynaptic cell to be greater than expected
nerve facilitation
increased released of NT and increases sensitivity to the NT
long term potentiation (involved in memory)
repeated stimulation causes decreased reaponse of post synaptic cell
synaptic fatigue due to depletion of NT stores
vasomotor center, respiratory center (DRG,VRG) swallowing, coughing and vomiting centers
medulla
micturition center, pneumotaxix, apneustic centers
pons
relay center for almost all sensationa
thalamus
contributes to balance
cerebellum
connects the two brain hemispheres
corpus callosum
anterior commissure
motor, personality, calculation
frontal lobe
somatosensory cortex
parietal lobe
vision
occipital lobe
hearing, vestibular processing, recognition of faces, optic pathway(meyers loop)
temporal lobe
plans and creates motor pattern for speech
Brocas speech
behavior, emotions, motivation
limbic association area
hippocampal lesions will
cause
Anterograde amnesia
thalamic lesions will cause
retrograde amnesia
production of oxytocin
paraventricular nuclei
production of vasopressin
supraoptic nuclei
satiety center
ventromedial nuclei
hunger center
lateral nuclei
sweating(heat release)
anterior hypothalamic area
shivering (heat conservation)
posterior hypothalamus
reward center
medial forebrain bundle
punishment center
central gray area around aqueduct of sylvius
social inhibition
amygdala
clinical assesment of brainstem functions in comatose patients use which evoked potential
Auditory evoked potential
ionic basis of absolute refractory period
no action potential occur until inactivation gates are open
site of initiation of ap in a neuron
initial segment
unmyelinated portion of the axon
nodes of ranvier
causes activation of synaptic vessels
calcium voltage gated channels
death of axon distal to site of injury
anterograde degeneration
changes to soma after axon is transected
axonal rxn/ chromatolysis