Neurophysiology Flashcards

1
Q

What are the 4 controls of the Nervous System?

A
  1. Control of internal environment
  2. Voluntary control of movement
  3. Programming of spinal cord reflexes
  4. Assimilation of experiences necessary for memory and learning
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2
Q

Define
degrees of freedom:

Motor equivalence:

How many degrees of freedom does the shoulder have?

A
  • the number of parameters of the system that may vary independently(simple terms: how many things can change - making a complex thing relatively simple and easier to control)
  • the ability to carry out a task in a different way by gain the same outcome, e.g.: writing with a pencil in between your teeth and have the same handwriting. This is done by freezing degrees of freedom
    ○ Shoulder has 3 degrees of freedom: movement up, down and twist
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3
Q

Why do we freeze the DF when learning a new skill?

A
  • To reduce the number of possibilities for movement
  • Increase control
  • This reduces the likelihood of the performance method affecting the person reaching the skill goal, which simplifies the control.
  • Not a clear understanding to whether this is the correct method to use when learning a skill
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4
Q

Define the Humoral mechanism:

A

when the bulk flow of liquids in an animal is through convection and diffusion
○ A difference of potentials is made by the movement of Cl- and Na+ to the other sides of the membrane(tiny fraction not balanced)

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5
Q

What are Bernstein’s stages of motor learning?

A
  • Stage 1: Freezing the degrees of freedom
    –> goal: minimise variability(e.g.: freezing the shoulder for a gun shot)
    ○ Coupling the body parts reduces the number of options of how to move
    ○ Not optimal technique, only happens early in skill acquisition
  • Stage 2: Releasing and reorganising
    –> goal: minimise variability of the pistol tip
    –> skilled: increase variability of individual joint motions
    ○ increased degrees of freedom than the start amount
  • Stage 3: Exploiting mechanical properties (e.g.: golf swing, effective skills make good use of mechanical properties)
    not applicable to all joints + the joint range of motion is not 0 at the beginning of learning
  • Values of 1 & -1 show a coupling or dependency between joints
  • 1 = joints move in phase
  • -1 = joints move out of phase
  • 0 = joint independence
  • Task type and task objectives, can influence the freezing of degrees of freedom. The coordination pattern made depends on the task constraints
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6
Q

Define:
Motor program

A

Motor program - “an abstract representation, that when initiated results in the production of a coordinated movement sequence”(Schmidt)

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7
Q

What are the levels to the Nervous System?

What direction are nerve impulses sent through the:
- afferent
- efferent

A

CNS –> Peripheral NS
Peripheral NS to both (afferent/sensory & efferent/motor)
efferent to both (somatic/skeletal & autonomic/involuntary)

Afferent - sensory info towards the NS
Efferent - takes info to effectors

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8
Q

Neuron:
What is contained in the soma?
What is the dendrites role?
What is the role of myelin?
What is the axon hillock dense in?
What is a group of axons called?
What are Schwann cells?

A
  • mitochondria
  • initiate the activation of new neurons
  • speeds up the action potential movement
  • sodium channels
  • neural tracts/nerves
  • contain large amounts of lipid protein substance called myelin innervating skeletal muscle
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9
Q

Describe an action potential:

How does it work?

What is a transmembrane potential?

A

The change in electrical potential associated with the passage of an impulse along the membrane of a muscle cell or nerve cell
* when the depolarisation of the neuron membrane reaches a “threshold” value an AP is formed

  • Transmembrane potential is the difference between the outside and inside of the membrane
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10
Q

What are the factors crucial for the propagation of an action potential?

A
  • Inactivation of sodium channels just after an action potential, leading to the absolute refractory period within the membrane
  • Different densities of sodium channels at different sections of the membrane
  • The action potential can only move in one direction, after exciting site 1 - 2 cannot re-excite site 1
  • The thicker the fibres the higher the velocity of the action potential
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11
Q

What is the resting potential of the neuron?

What is a Rheobase?

A
  • -70mV - the higher conductance of Cl- ions as compared to the conductance of K+/Na+
  • Rheobase - the strength a stimulus must be, even with an increase in duration an action potential cannot be stimulated
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12
Q

How is the resting potential determined?

A
  • The permeability of the membrane to different ions
  • The difference in concentrations between the intracellular and extracellular ions
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13
Q

How is the threshold stimulated?

A
  • Rapid rush of sodium when gate opens is the action potential
  • The depolarisation are known as excitatory post-synaptic potentials(EPSPs), which is reached by temporal/spatial summation
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14
Q

Identify the 3 parts in synaptic transmission:

A
  • Presynaptic membrane - transmits information coded by a sequence of action potentials
  • Postsynaptic membrane - the cell receiving information
  • Synaptic cleft - the gap between the pre and post synaptic neurons
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15
Q

What are the 2 groups of synapses?

A
  • Obligatory - action potential on the presynaptic membrane that always gives rise to an action potential on the postsynaptic membrane e.g.: neural cells and muscle cells
  • Non-obligatory - an action potential on the presynaptic membrane that is typically unable to induce and action potential on the postsynaptic membrane
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16
Q

What are neurotransmitters?

What are neuropeptides?

A
  • Produced by the presynaptic neuron and stored in a reservoir close to the presynaptic membrane
  • Most frequently known as GABA (amino acids glutamine and leucine), also biogenic amines
  • These modulate the synaptic efficacy of other neurotransmitters e.g.: endorphins
17
Q

What is meant by:
inactivation

Absolute refractory period

Relative refractory period

A
  • Once sodium enters - action potential is triggered, cannot have another action potential until the refractory period has passed (inactivation) during this
  • when the conductance cannot be increased by an external voltage the membrane is in absolute refractory period
  • When the increase in conductance is needed to be a greater voltage the membrane is in relative refractory period
18
Q

Describe the function of myelinated fibres:

A
  • Myelin sheath that increases the distance at which local currents from an action potential is able to reach the threshold of the membrane depolarization
  • Sodium channels are concentrated in Ranvier nodes so that their density at the nodes is much higher than non-myelinated fibres(density under the fibres is much lower)
  • These allow the action potential to jump to neighbouring nodes
  • Thick nodes have larger intervals = action potentials are conducted at a higher velocity
19
Q

What is the difference between temporal and spatial summation?

A
  • Temporal - from the same dendrites - time, with repeated excitation from a single presynaptic neuron
  • Spatial - a lot from different dendrites - EPSPs come into the postsynaptic neuron from numerous different excitatory inputs
20
Q

What are some affecters of action potential propagation?

A
  • Na channel inactivity
  • Na channel density
  • myelin
  • Ranvier nodes