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Neuro Quiz 1 > Neuropharmacology > Flashcards

Neuropharmacology Flashcards

1
Q

Amino Acid NT =

A

Serotonin and GABA

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2
Q

Catecholamine NT =

A

NE, dopamine, EPI

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3
Q

Synaptic Neurotransmission Process

A

AP leads to calcium influx which causes exocytosis of NT vesicles that can act on ionotropic, metabotropic or presynaptic receptors
They then get reuptaken/metabolized, membranes get recycled, dense core granules with neuropeptides come out to release neuropeptides

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4
Q

NT that are reuptaken =

A

Dopamine, NE, GABA

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5
Q

NT that are metabolized =

A

ACh and peptides

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6
Q

NT that are reuptaken by glial cells =

A

Glutamate

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7
Q

Excitatory NT

A

propagates signal farther to have more action potentials down the line

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8
Q

Inhibitory NT

A

hyperpolarization and signal will not be propagated any further

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9
Q

Important for drug binding a specific receptor

A

Hydrophobicity
pKa
Conformation
Spatial arrangement

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10
Q

Ionotropic receptors =

A

ligand gated ion channels

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11
Q

Define Ionotropic receptors

A

Release NT causes electrical effects on postsynaptic neuron by opening a specific ion channel
Complex

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12
Q

Metabotropic receptors =

A

G-protein coupled receptors

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13
Q

Define Metabotropic receptors

A

Single subunit
Conformation change which activates this family
Serotonin!!!

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14
Q

Glutamate is synthesized from

A

Glutamine is released by glial cells and broken down via presynaptic terminals

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15
Q

Glutamate is what type of NT

A

Fast EXCITATORY

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16
Q

Ionotropic glutamate receptors Non-NMDA

A

Fast depolarization (AMPA and kainate)

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17
Q

Ionotropic glutamate receptors NMDA

A

Learning/memory

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18
Q

GABA is synthesized from

A

Glutamate

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19
Q

GABA is what type of NT

A

Inhibitory

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20
Q

GABA purpose is

A

Prevent neurons from firing too often and too easily

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21
Q

Low GABA =

A

anxiety, seizures, PARKINSON’s

22
Q

GABA(A) =

A

ionotropic
Modulator of barbiturates and BZD
Antagonists for flumazenil

23
Q

GABA(B) =

A

Metabotropic GPCR

Agonist baclofen

24
Q

GABA(C)/GABA(A)-rho =

A

Ionotropic

Brain and retina

25
Q

GABA(A) drugs

A 
Benzo
Barbiturates
Anesthetics
Neurosteroids
Alcohol
ANTAGONISTS- picrotoxin
AGONIST - muscimol
26
Q

ACh synthesized from

A

acetyl CoA and choline via choline acetyltransferase

27
Q

ACh is brokendown by

A

AChE

Butyrylcholinesterase

28
Q

ACh acts on

A

Nicotinic and muscarinic receptors

29
Q

Nicotinic Receptors + ACh

A

Ionotropic

Excitatory

30
Q

**Muscarinic Receptors + ACh

A

Metabotropic
Excitatory at M1, M3, M5
Inhibitory at M2 and M4

31
Q

**Catecholamine synthesis

A

Tyrosine to DOPA via tyrosine hydroxylase (RATE LIMITING)
DOPA to Dopamine via DOPA decarboxylase
Dopamine to NE via dopamine beta hydroxylase

32
Q

NE NT

A

Inhibitory via beta receptors in the brain

some excitatory through alpha or beta

33
Q

NE Functions

A

Arousal
BP regulation
Control of mood (big in depression)

34
Q

NE Termination =

A

reuptake into noradrenergic nerve endings

35
Q

Uses for alpha adrenoreceptors agonists

A

(a1) Symptomatic relief of nasal congestion

(a2) BP lowering

36
Q

Uses of beta adrenoreceptors agonists

A

(b2) asthma

37
Q

Inhibitors of NE reuptake (prolong effects)

A

TCA

Cocaine

38
Q

Drugs affecting NE synthesis

A

Carbidopa, methyldopa

39
Q

Drugs affecting NE release and storage

A

Reserpine

40
Q

Drugs inhibiting metabolism

A

MAOIs

41
Q

Not enough dopamine =

A

Parkinson’s!!! (in nigrostriatal pathway)

Schizo, ADD, drug addiction

42
Q

Dopamine is broken down by

A

COMT and MAO

43
Q

Dopamine is what type of NT

A

Metabrotropic
Excitatory in D1 and D5
Inhibitory in D2, D3, D4

44
Q

Dopamine functions

A 
Motor control (D2)
Endocrine control (prolactin - inhibitory)
Behavioral (D1; pleasure, addiction, correct thinkin)
45
Q

Dopamine precursors =

A

Levodopa

46
Q

Dopamine receptor agonists =

A

Bromocriptine, pergolide

47
Q

MAO-B inhibitors =

A

Selegiline/rasagiline

48
Q

Dopamine receptor blockers =

A

Antipsychotic effects (D2) for schizo

49
Q

Serotonin is what type of NT

A

Metabotropic

50
Q

Serotonin Types and Metabolism

A

7 types mainly in CNS

Metabolized by MAO

51
Q

Serotonin Functions

A

Hallucinations/behavior
Sleep/wakefulness/mood
Feeding (appetite)

Neuro Quiz 1 (3 decks)

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