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Neuro Quiz 1 > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

Tertiary Amines

A

Inhibit 5-HT (mood stabilizing)

More interactions with other receptors

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2
Q

Secondary Amines

A

Inhibit NE (more activating/motivation)

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3
Q

Tertiary amines are

A

Imipramine
Doxepin
Amitryptiline
Clomipramine

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4
Q

Secondary Amines

A

Desipramine

Nortyrptiline

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5
Q

TCA AE

A

Muscarinic Cholinergic (MI) Blockade
Constipation, dry mouth, drowsiness, blurred vision
Urinary retention, tachycardia, ataxia, low perspiration

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6
Q

Sympathomimetic effects of TCA

A

Tachycardia, tremor, HTN bc of NE uptake

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7
Q

Anti-Adrenergic effects of TCA

A

alpha 1 orthostatic hypotension

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8
Q

GI Disurbances/Sexual Dyfunction effect of TCA

A

due to 5HT uptake (increased levels of 5HT

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9
Q

Central Adrenergic Blockade effects of TCA

A

Dizziness, drowsiness, hypotension

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10
Q

Central H1 Histaminergic Blockade effects of TCA

A

Weight gain and drowsiness

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11
Q

Which TCAs have HIGH antihistaminic activity

A

Amitryptiline, doxepine, trimipramine

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12
Q

TCAs + Ion Channels

A

High doses = suicidal
Cause excitation, delirium, convulsions, arrhythmias
Due to blocked sodium ion channels!!!

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13
Q

Irreversible and approved MAOIs

A

Tranylcypromine (Parnate)
Phenelzine (Nardil)
Isocarboxazid

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14
Q

MAOI SE

A

Excessive central stimulation (headache, insomnia, tremor, excitement)
Orthostatic hypotension
Increased appetite and weight gain
Constipation, dry mouth, blurred vision (atropine effects)
Liver toxicity (phenelzine)

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15
Q

MAOI + Tyramine

A

Severe increase in BP bc tyramine/NE cannot be inactivated

So dietary restrictions of (aged cheese and red wine)

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16
Q

MAOI Drug of Choice?

A

No, second line because of interactions

- SSRIs are first

17
Q

Enhanced synaptic NE leads to

A

Vasoconstriction and HTN

18
Q

MAOI Interactions

A

***Decongestants (phenylephrine - alpha 1 agonist, ephedrine- alpha/beta agonists, pseudoephedrine, phenylpropanolamine- alpha 1 agonist)
Amphetamines, methylphenidate
TCAs, NRIs, SNRS, NDRS
Sibutamine, phentermine

19
Q

MAOI Serotonin Interactions

A 
SSRI
SNRI
TCA
Cyclobenzaprine, carbamazepine
Sibutramine
Opiods

Neuro Quiz 1 (3 decks)

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