Neuropharmacology

Question 1

What are the six steps of adrenergic transmission

Answer 1

NE synthesis
Vesicle uptake of NT
Release of NT
Receptor interactions
Reuptake
metabolism

Question 2

What is the major mechanism of termination of action of adrenergic transmission

Answer 2

reuptake

Question 3

What are the three types of adrenergic receptors

Answer 3

alpha, beta, dopamine

Question 4

What are the prominent effector organs/locations of alpha 1 receptors

Answer 4

arterioles, veins, uterus

Question 5

What is the response to alpha 1 receptor activation

Answer 5

increase Ca2+ and contraction

Question 6

What will the response be to an alpha 2 receptor being activated

Answer 6

inhibition of NE release at the presynaptic nerve ending
decrease in sympathetic tone in CNS

Question 7

Which adrenergic receptor is associated with the heart primarily

Answer 7

Beta 1

Question 8

What two adrenergic receptors have opposing affects on arterioles and uterine smooth muscle

Answer 8

alpha 1 and beta 2

Question 9

What adrenergic receptor is associated with lipocytes?

Answer 9

B3

Question 10

What receptor is the main modulator of BP?

Answer 10

alpha1

Question 11

Which receptor will have a greater affect on blood pressure alpha 1 or beta 2

Answer 11

alpha 1

Question 12

What are the adrenergic agonist effects on blood pressure

Answer 12

increased by alpha1
decreased by alpha 2 and beta 2
indirectly increased by beta1

Question 13

What are the adrenergic agonist effects on the heart

Answer 13

increase contraction by activation of beta1

Question 14

What are the adrenergic agonist effects on the smooth muscle of the GI tract

Answer 14

decrease in motility by alpha2 and beta 2
increased sphincter contraction by alpha1

Question 15

What are the adrenergic agonist effects on the urinary bladder

Answer 15

contraction of internal sphincter by alpha 1
relaxation of the fundus by beta 2

Question 16

What are the adrenergic agonist effects on the bronchioles

Answer 16

relaxation

Question 17

What are the adrenergic agonist effects on the eye

Answer 17

mydriasis
decreased intraocular pressure

Question 18

What are the adrenergic agonist effects on metabolism

Answer 18

increase blood glucose (beta2)
decrease insulin secreation (alpha2)
stimulate glucagon secretion (beta 2)

Question 19

What are some clinical applications of adrenergic agonist?

Answer 19

1. anaphylactic shock/hypersensitivity rxns
   2.Congestive heart failure
2. AV block
3. Cardiac & septic shock
4. cardiac arrest
   6.local hemostatic agents
5. prolong local anesthetic effects
6. nasal decongestants
   9.urinary bladder sphincter incompetence
7. brinchodilator
8. open angel glaucoma
9. sedation

Question 20

What are the adrenergic alpha antagonist effects on the cardiovascular system

Answer 20

decreases blood pressure

Question 21

What are the adrenergic alpha antagonist effects on the eye

Answer 21

miosis

Question 22

What are the adrenergic alpha antagonist effects on the bladder

Answer 22

relaxation of sphincter

Question 23

What are the adrenergic beta antagonist effects on cardiovascular system

Answer 23

decrease in all of the things

Question 24

What are the adrenergic beta antagonist effects on the resp system

Answer 24

bronchoconstriction

Question 25

What are the adrenergic beta antagonist effects on the eye

Answer 25

reduce intraocular pressure

Question 26

What are adverse effects of adrenergic alpha antagonists

Answer 26

hypotension
reflex bradycardia
CNS stimulation

Question 27

What are adverse effects of adrenergic beta antagonists

Answer 27

decreased cardiac output
bradycardia
bronchospasms