neuropathology lab

Question 1

removal of brain should include what other structures

Answer 1

◼ Include pituitary and ganglion of V.

Question 2

Lesions to look for in brain

Answer 2

◼ Abnormalities of occiput
◼ Cerebellar herniation
◼ Cerebral edema
> Flattening of gyri, dissymmetry, tentorial herniation, coning of cerebellum
◼ Meningitis
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also look at proportions of cerebrum to cerebellum

Question 3

Embryology of Brain - parts

Answer 3

◼ Rhombencephalon
◼ Mesencephalon
◼ Prosencephalon
◼ Ventricular system

Question 4

Indications for removing the brain

Answer 4

◼ Neurological signs
◼ No lesions found in body to explain death
◼ Medicolegal

Question 5

Cerebrospinal Fluid - where is it produced? where does it go?

Answer 5

◼ Choroid plexus of lateral, third and fourth ventricles
◼ Interventricular foramen (Monro)
◼ Mesencephalic Aqueduct (Sylvius)
◼ Foramina of fourth ventricle (Luschka)
◼ Arachnoid cistern

Question 6

Precautions for removing brain

Answer 6

Prevent Autoimmune Encephalomyelitis /multiple
sclerosis
◼ Aerosols – breathing apparatus
◼ Transcutaneous translocation – high pressure hoses
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Viruses
◼ Rabies lyssavirus
◼ Arboviruses

Question 7

Fixation and processing of brain, process

Answer 7

Fixation
◼ Takes days to fix a brain
◼ Change formalin several times
◼ After sequential sectioning, wrap in paper towel, tie with string and refix