Neurons & The Nervous System Flashcards

1
Q

Why is a nervous system needed?

A
  • Communication between different areas of the organism.
  • Controls functions of the organism (e.g. movement).
  • Regulates responses to conditions or stimuli (e.g. homeostasis).
  • Found in most multicellular organism but varies in complexity.
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2
Q

What are neurons?

A

Excitable cells capable of producing and transmitting action potentials.

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3
Q

What is an action potential?

A

The transient change in the potential difference (voltage) across the membrane of a neuron that form the basis of communication.

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4
Q

What are the 3 main components of a neuron?

A
  1. Soma - cell body that contains the nucleus and is the site of protein synthesis. Important role in integrating inputs from dendrites of cell.
  2. Dendrites - Many per neuron. Receive incoming inputs and converge on the soma.
  3. Axons - A single axon carries the AP to the next neuron. Axon terminals branch into many terminal boutons and are insulated with the myelin sheath.
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5
Q

What is a synapse?

A

The connection between neurons that transmit signals from one cell to the next. Uni-directional going from an axon terminal of one nerve to the dendrite of next nerve.

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6
Q

How do synapses communicate?

A
  1. AP travels down presynaptic cell.
  2. AP stimulates the release of neurotransmitter across the synapse from the synaptic vesicles.
  3. Neurotransmitter binds to receptors on postsynaptic cell.
  4. Receptor binding triggers AP in postsynaptic cell.
  5. Impulse continues along the postsynaptic cell.
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7
Q

How are neurotransmitters removed from the synapse?

A
  1. Neurotransmitters can be returned to axon terminals for reuse or transported into glial cells.
  2. Enzymes can inactivate them.
  3. Neurotransmitters can diffuse out of the synaptic cleft.
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8
Q

Why must neurotransmitters be removed from the synapse?

A

To ensure the nervous system signalling is rapid and dynamic.

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9
Q

What do the terms divergence and convergence mean and what determines which one is used?

A

Divergence - Synapses expand signals throughout the nervous system.
Convergence - Synapses specifically channel signals down a certain nerve tract.
It is determined by the numbers of presynaptic vs postsynaptic neurons.

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10
Q

What do afferent (incoming) neurons do?

A
  • Carry information from periphery to nervous system.

- Convert sensory information into AP’s using a variety of specialised receptors.

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11
Q

What do efferent (outgoing) neurons do?

A

Carry commands from the nervous system to effectors (e.g. glands and muscles).

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12
Q

What do interneurons (i.e. circuit or relay neurons) do?

A
  • Form connections and circuits between neurons.
  • Often connect afferent neurons to efferent neurons.
  • Increases the complexity of the nervous system.
  • Involved in storing information.
  • Short and simple in structure and almost always found in the CNS only.
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13
Q

Why are reflexes important?

A

To protect us by removing us from injuries situations quickly.

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14
Q

What is the withdrawal reflex?

A

The simplest reflex that involves one afferent, one efferent and one interneuron. Doesn’t require the impulses to travel to the brain (only spinal cord) and facilitates a rapid response called the spinal reflex.

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15
Q

Describe the stages of a withdrawal reflex when touching something hot.

A
  1. Heat activates skin receptors.
  2. Produces AP in dendrites of afferent neuron.
  3. AP travels to SC.
  4. Activates dendrites of interneuron.
  5. AP is relayed through interneuron to the efferent neuron.
  6. Impulse travels down axon of efferent neuron.
  7. Stimulates muscle contraction to move arm.
  8. Arm removed from flame.
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16
Q

What is a neural network?

A

Arrangements containing more than one nerve cell which vary in complexity and degree of interconnection.

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17
Q

What is a nerve net?

A

The simplest network with small numbers of connected neurons.

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18
Q

What is a nervous system network?

A

A complex network with huge numbers of cells connected and often contains many sub-divisions and components.

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19
Q

What are ganglia?

A

Paired or grouped neurons.

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20
Q

What is the brain and the spinal cord?

A

Brain - main processing consisting of 2 hemispheres and the largest pair of ganglia.
Spinal cord - Thickened cluster of nerve fibres which connects distant parts of organism.

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21
Q

What is the simple nerve network of the sea anemone?

A

Simple nerve nets innervate the anemone. Lengthy projections with a few connections but not highly branched. Permits simple responses, reflexes and functions such as contraction and relaxation.

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22
Q

What is the more complex nerve network of the earthworm?

A

Ganglia in each segment of the worm co-ordinate movement through segmental nerves. The anterior ganglia acts like a control centre to co-ordinate more complex behaviour and integration.

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23
Q

What is the more complex nerve network in a squid?

A

More specialised, organised pattern which gives a greater degree of integration and complex behaviour. Specialised ganglia co-ordinate specific functions through specific nerve projections and sensory systems are more developed.

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24
Q

What are the 2 component systems of the most advanced nervous system (humans)?

A
  1. CNS - brain and spinal cord, processing centre, encased in bone.
  2. PNS - Information relay and communication system,
25
Q

What are the functions of glial cells?

A
  1. Support and hold neurons in place.
  2. Nourish and supply nutrients/O2.
  3. Insulate neurons electrically.
  4. Protect from pathogens.

Glial cells have no electrical function.

26
Q

What are the 4 types of glial cells?

A

Astrocytes (CNS only), Schwann cells (PNS only), oligodendrocytes (CNS only) and microglia (CNS).

27
Q

What is the blood brain barrier?

A

The brain blood capillaries are less permeable and leaky than other capillaries. The endothelial cells in the brains capillaries fit together well and are reinforced by the sticky feet of the astrocyte projections, forming a BBB. The cell membranes of the BBB are permeable to fat-soluble substances so therefore fat-soluble drugs have rapid effects on the CNS.

28
Q

What do astrocytes do?

A
  • Star-shaped
  • Support and protect neurons.
  • Contribute to BBB.
  • Protect brain from toxins in the blood.
  • Projections contact capillaries and neurons.
  • Role in inflammatory response in brain.
  • Control and co-ordinate other glial cells types.
29
Q

What do Schwann cells do?

A
  • Rich in lipid and produce myelin in PNS which provides electrical insulation.
  • Wrap around axons to provide myelin sheath.
  • Many Schwann cells per axon.
  • Gives white appearance.
  • Myelin enhances the speed of electrical conductance. The impulse jumps between nodes of ranvier and this is termed saltatory conduction.
30
Q

What do oligodendrocytes do?

A
  • Myelin-producing cells in CNS.
  • Highly branched.
  • Processes contact several axons and coat in myelin.
  • A single ODC produces myelin for several neurons.
31
Q

What is multiple sclerosis?

A

Disease of the myelin where the immune system destroys the sheath (an autoimmune disease). This reduces speed and success of nerve conduction (loss of saltatory conduction). Symptoms include pins and needles, loss of motor function and visual disturbance. The symptoms depend on location and severity of demyelination.

32
Q

What do microglia do?

A
  • Small immune cells that act as phagocytes.
  • Look for debris in CNS to ingest.
  • The primary immune defence in CNS.
  • Very important as there are few antibodies in the BBB.
  • Work closely with astrocytes to protect neurons.
33
Q

Why does the CNS not repair itself after injury, often leading to permanent paralysis?

A

Glial cells from a barrier against repair. Following injury astrocytes divide and become reactive. They invade the injury site and attract microglia. This is designed to limit the spread of injury and protect the remaining CNS. A plaque is formed which acts as a physical barrier to axon growth over the injury site. Inhibitory molecules are also secreted to act as a chemical barrier to regrowth.

34
Q

What are vertebrates and what is their nervous system?

A

Animals with internal skeletal structures. Most nerves are found within a central region which is associated with storage and processing (CNS). There is huge variation between vertebrates depending on the complexity of the animal.

35
Q

What are the 3 regions of vertebrate brains?

A

Brain stem/medulla - controls basic autonomic functions.
Cerebellum - Integrates sensory and motor movements (precision).
Cerebrum - Complex behaviour, emotions, learning, memory.

36
Q

What is the most prominent area in the human brain and what is this area associated with?

A

The cerebrum:

  • Complex behaviour, socially aware and conscious.
  • Capable of advanced learning and memory.
  • Complex personality structure.

Humans also have a highly evolved cerebellum but a comparatively poorly developed olfactory lobe (more reliant on other sensory systems).

37
Q

What is the neural tube?

A

A hollow tube of tissue that runs the length of an early embryo on dorsal surface.

38
Q

What is the forebrain of an embryo divided into?

A
  1. Telencephalon - Becomes cerebrum, 2 hemispheres, complex array of lobes, perception/learning/memory/conscious behaviour.
  2. Diencephalon - forebrain relay site. Composed of thalamus (final sensory relay between spinal cord and forebrain) and hypothalamus (regulates many functions).
39
Q

What is the hindbrain composed of?

A
  1. Cerebellum (dorsal outgrowth) - Intricate control of motor and sensory function.
  2. Pons and medulla (brain stem) - Connects spinal cord and brain, controls involuntary functions.
40
Q

What is the midbrain (also part of brain stem)?

A

Has a number of structures associated with sensory input. Mainly vision and olfaction (smelling).

41
Q

What is the corpus callosum and what does it do?

A

A thick band of nerve fibres that allow the 2 hemispheres of the brain to communicate and work together.

42
Q

What is grey and white matter?

A

Grey - neuronal cell bodies.
White - Axons.
The outer region of the brain (cerebral cortex) is the grey matter. The region underneath is the white matter.

43
Q

What is the cerebral cortex made up of?

A

Ridges called gyro and valleys called sulci.

44
Q

What are the 4 lobes of the brain hemispheres?

A

Temporal, frontal, parietal, occipital.

45
Q

What is contralateral control?

A

The right hemispheres associated with sensory and motor function of the left side of the body and vice versa. Only a few areas of the cortex have an exact defined function. Other areas are termed association cortex (they are associated with specific functions).

46
Q

What is the function of the temporal lobe?

A
  • Auditory processing.
  • Helps with recognising and naming objects.
  • Damage to these regions causes agnosia which is where you are aware of an object but cannot name it.
  • Also important for identifying faces.
47
Q

What is the function of the frontal lobe?

A

Contains the primary motor cortex. Stimulation of specific areas causes a specific muscle contraction. The body is ‘mapped’ onto the primary motor cortex. Other functions of the frontal lobe include a specific role in personality, planning, social conscience and awareness.

48
Q

What is the central sulcus?

A

Separates the parietal and frontal lobes.

49
Q

What is the story of Phineas Gage?

A

A railroad construction worker who had explosives explode in his face. This sent a 3 metre long tamping rod into his head below the left eye, through his frontal lobe and out the top of his head. He survived this but then became bad-tempered, lazy, irresponsible, and unrecognisable to the character he was before the accident. This was because his frontal lobe was destroyed which proves its role in higher functions and personality.

50
Q

What is the function of the parietal lobe?

A

Contains the primary somatosensory cortex. Stimulation of specific areas causes localised sensation in specific areas of the body. The body is ‘mapped’ onto the somatosensory cortex. Somatosensory relates to the sensation of touch and larger areas relate to more touch sensitive body regions. Sensory inputs from the body go first to the thalamus and then to the somatosensory cortex. Other functions of the parietal lobe include responding and interpreting complex stimuli.

51
Q

What is contralateral neglect syndrome and what causes it?

A

Causes by damage to the right parietal lobe. Patients may be unable to process sensory information regarding the left side of the body.

52
Q

What is the function of the occipital lobe?

A

Receives and processes visual information. Complex integration creates binocular vision which permits greater level of detail and depth perception. Association ares help is to understand what we see and are also concerned with articulating what we see.

53
Q

How have we managed to learn what the different areas of the brain do?

A

From studies of brain-damaged patients, and PET, MRI and fMRI scans.

54
Q

What is position emission tomography (PET) scanning?

A

A radioactive substance is injected and detected as it passes through the brain. This allows detection of active areas of the brain.

55
Q

What is the auditory processing process when speaking a written word?

A
  1. Words are detected by the visual cortex.
  2. Processed by Wernicke’s area.
  3. Transmitted to Broca’s area.
  4. Broca’s area stimulates the motor cortex to speak the word.
56
Q

What is the auditory processing process when speaking a heard word?

A
  1. Words are detected by auditory cortex.
  2. Processed by Wernicke’s area.
  3. Transmitted to Broca’s area.
  4. Broca’s area stimulates the motor cortex to speak the word.
57
Q

What happens when Wernicke’s area is damaged and what is it called?

A

The patient cannot understand visual or spoken communication. As a result, their own spoken communication doesn’t make sense. This is called receptive aphasia/Wernicke’s aphasia.

58
Q

What happens when Broca’s area is damaged and what is it called?

A

The patient can understand visual and spoken communication but cannot produce and sensible spoken or written language. This is called expressive aphasia/Broca’s aphasia.