neurons and synaptic transmission Flashcards
synaptic transmission is a method of neurone communicating with each other relaying information to the CNS across
sensory neurons and carrying out responses dictated by the brain through sending information to effectors via motor neurons
synaptic transmission 1
an action potential arrives at the presynaptic membrane causing depolarisation through the opening off
voltage dependent calcium ion channels and the consequent influx of calcium ions
synaptic transmission 2
the increased concentration of calcium ions with the membrane causes the vesicles containing neurotransmitters to fuse with the
presynaptic membrane and release their contents into the synaptic cleft through exocytosis
synaptic transmission 3
the neurotransmitter diffuses across the synaptic cleft down a concentration gradient and binds to complementary receptors on the spot synaptic membrane this can result in
a inhibitory or excitatory effect in the post synaptic membrane
synaptic transmission 4
the resultant action potential will then be transmitted along the axon of the following neuron resulting in a
cascade of neurotransmission
inhibitory transmitters ie serotonin reduce the differences across the post synaptic membrane through the closure of the voltage dependent sodium ion channels reducing
the likelihood that an action potential will be generated
excitatory transmitters ie dopamine
increase the potential diffrence across the postsynaptic membrane through triggering the opening of more voltage dependent sodium ion channels increasing
the likelihood that an action potential will be generated