Neuron Injury

Question 0

Changes in axon proximal to lesion

Answer 0

Same as distal axon but only to first Node of Ranvier

Question 1

Changes in axon distal to lesion

Answer 1

• Wallerian degeneration
• in PNS replaced by fibrous scar tissue
• in CNS astrocytes proliferate and replace axon

Question 2

Changes in neuronal cell body following axon lesion

Answer 2

• Retrograde degeneration
• Due to lesion citation of cell body from end organs
• Chromatolysis and swelling
• Synaptic stripping

Question 3

Definition of anterograde transferral degeneration

Answer 3

Injury to neuron group causing degenerative changes to a second neuron group further down the pathway

Question 4

3 types of nerve injury

Answer 4

1. Neuropraxia (transient block)
2. Axonotemesis (lesion where axons damaged but conn. tissue intact)
3. Neurotemesis (complete section)