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NURS 575 - Pharm Workbook > Neuromuscular Reversal > Flashcards

Neuromuscular Reversal Flashcards

1
Q

Neostigmine/Prostigmin, Bloxiverz

  • MOA
  • Side effects
A

MOA: acetylcholinesterase inhibitor - prevents breakdown of acetylcholine in neuromuscular junction

Side effects:

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2
Q

Neostigmine/Prostigmin, Bloxiverz

  • Dose
  • Onset
  • Peak
  • Duration
A

Dose:

  • 0.03-0.07 mg/kg
  • max 5mg (> 71 kg)

Onset: 1 minute

Peak: 9 minutes

Duration: 20-30 minutes

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3
Q

Neostigmine/Prostigmin, Bloxiverz

  • Metabolism/Excretion
  • Characteristics/observations
A

Metabolism/Excretion: 50% renal excretion

Characteristics/observations:

  • antiemetic properties
  • muscarinic effects must be blocked
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4
Q

Edrophonium/Enlon

  • MOA
  • Side effects

NOT AVAILABLE IN US MARKET

A

MOA: acetylcholinesterase inhibitor - prevents breakdown of acetylcholine in the synaptic cleft

Side effects:

NOT AVAILABLE IN US MARKET

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5
Q

Edrophonium/Enlon

  • Dose
  • Onset
  • Peak
  • Duration

NOT AVAILABLE IN US MARKET

A

Dose:

  • 0.5-1 mg/kg (0.05-0.1 ml/kg) over 45-60 seconds

Onset: 3 minutes?

Peak: 1.2 minutes?

Duration: 70 minutes

NOT AVAILABLE IN US MARKET

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6
Q

Edrophonium/Enlon

  • Metabolism/Excretion
  • Characteristics/observations

NOT AVAILABLE IN US MARKET

A

Metabolism/Excretion:

  • 75% renal excretion
  • Elimination half-life = 33-110 minutes

Characteristics/observations:

  • ?

NOT AVAILABLE IN US MARKET

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7
Q

Sugammadex/Bridion

  • MOA
  • Side effects
A

MOA: cyclodextrin which encapsulates NMBA, reducing amount present in neuromuscular junction

Side effects: will inhibit oral contraceptives for 7 days

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8
Q

Sugammadex/Bridion

  • Dose
  • Onset
  • Peak
  • Duration
A

Dose:
(dependent on TOF)
* TOF = 2: 2 mg/kg
* TOF = 0-2: 4 mg/kg
* More profound: 8-16 mg/kg

Onset: 1-5 minutes

Peak: ?

Duration: 120 minutes

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9
Q

Sugammadex/Bridion

  • Metabolism/Excretion
  • Characteristics/observations
A

Metabolism/Excretion: 75% renal excretion

Characteristics/observations:

  • antiemetic properties
  • muscarinic effects must be blocked
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NURS 575 - Pharm Workbook (20 decks)

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