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NURS 575 - Pharm Workbook > Inhaled Anesthetics > Flashcards

Inhaled Anesthetics Flashcards

1
Q

Suprane/Desflurane

  • Type
  • Vapor Pressure
  • Chemical Structure
A
  • Type:
    Halogenated Ether
  • Vapor Pressure:
    669
6 Fluorines
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2
Q

Suprane/Desflurane

  • MAC
  • Blood gas partition coefficient
A
  • MAC:
    6 (some texts say 5.8 or 6.6)
  • Blood gas parition coefficient:
    0.42
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3
Q

Suprane/Desflurane

  • Metabolism
  • Physiologic effects (cardiovascular, respiratory, etc)
  • Characteristics/observations
A

Metabolism:

  • 0.02% in liver

Physiologic effects:

  • ↑ HR ↓ SVR, ↓ BP, ↓ inotropy
  • Prolongs QTc, arrhythmogenic with epi
  • ↓ tidal volume, ↑ RR (minimal), ↓ central response to CO2 and hypoxia, bronchodilation

Characteristics/observations:

  • In the presence of dessicated soda lime CO is produced
  • Pungent odor
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4
Q

Ultane/Sevoflurane

  • Type
  • Vapor Pressure
  • Chemical Structure
A
  • Type:
    Halogenated Ether
  • Vapor Pressure:
    157
7 Fluorines
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5
Q

Ultane/Sevoflurane

  • MAC
  • Blood gas partition coefficient
A
  • MAC:
    2
  • Blood gas partition coefficient:
    0.68
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6
Q

Ultane/Sevoflurane

  • Metabolism
  • Physiologic effects (cardiovascular, respiratory, etc)
  • Characteristics/observations
A

Metabolism

  • 5-8% in liver

Physiologic effects:

  • ↔ HR, ↓ SVR, ↓ BP, ↓ inotropy
  • Prolongs QTc, arrhythmogenic with epi
  • ↓ tidal volume, ↑ RR (minimal), ↓ central response to CO2 and hypoxia, bronchodilation

Characteristics/observations:

  • In the presence of dessicated soda lime compound A is produced (especially in old absorbers)
  • < 2 MAC hours at FGF 1-2 L/min minimizes compound A in old absorbers
  • Non-pungent odor
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7
Q

Forane/Isoflurane

  • Type
  • Vapor Pressure
  • Chemical Structure
A
  • Type:
    Halogenated Ether
  • Vapor Pressure:
    238
5 Fluorines
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8
Q

Forane/Isoflurane

  • MAC
  • Blood gas partition coefficient
A
  • MAC:
    1.17
  • Blood gas parition coefficient:
    1.43
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9
Q

Forane/Isoflurane

  • Metabolism
  • Physiologic effects (cardiovascular, respiratory, etc)
  • Characteristics/observations
A

Metabolism

  • ?

Physiologic effects:

  • ↑ HR, ↓↓ SVR, ↓↓ BP, ↓↓ inotropy ( ↓ > iso or des)
  • Prolongs QTc, arrhythmogenic with epi
  • ↓ tidal volume, ↑ RR (minimal), ↓ central response to CO2 and hypoxia, bronchodilation

Characteristics/observations:

  • Pungent odor
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10
Q

Nitrous Oxide

  • Type
  • Vapor Pressure
  • Chemical Structure
A
  • Inorganic gas
  • Vapor Pressure: 33,870
Either structure
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11
Q

Nitrous Oxide

  • MAC
  • Blood gas partition coefficient
A
  • MAC: 105
  • Blood gas parition coefficient: 1.43
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12
Q

Nitrous Oxide

  • Metabolism
  • Physiologic effects (cardiovascular, respiratory, etc)
  • Characteristics/observations
A

Metabolism

  • 0.004% in liver

Physiologic effects:

  • ↑ HR, ↑ SVR, ↑ BP, ↑ PVR, ↑ PAP, ↓ Inotropy CO/CI
  • PONV

Characteristics/observations:

  • Diffuses into gas filled spaces
  • Non-pungent odor
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NURS 575 - Pharm Workbook (20 decks)

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