Neuromuscular blockade and reversal

Question 1

what factors potentiate neuromuscular blockade?

Answer 1

hypothermia, acidosis, hypoK, hypoCa, hyperMg

Question 2

which non-depolarizing agent does Add to dictionary not reverse?

Answer 2

cisatracurium and atracurium - they are benzylisoquinolones as opposed to the others which are steroidal

Question 3

intubation dose of succinylcholine?

Answer 3

1-2mg/kg

Question 4

intubation dose of rocuronium?

Answer 4

0.6-0.8 mg/kg

Question 5

intubation dose of cisatracurium?

Answer 5

0.2 mg/kg

Question 6

intubation dose of vecuronium?

Answer 6

0.12 mg/kg

Question 7

reversal dose of neostigmine?

Answer 7

0.04-0.08 mg/kg (2.5mg)

Question 8

dose of glycopyrrolate?

Answer 8

0.2 mg per 1mg of neostigmine or

Question 9

affects of neostigmine are usually apparent in how many mins?

Answer 9

5 to 10min

Question 10

when Ach binds to both alpha receptors the channel opens and allows what to flow through?

Answer 10

Na and calcium - creating end plate potential. When 5 to 20% of receptor channels are open and a threshold potential is reached and muscle action potential is generated.

Question 11

diseases sensitive to Sux

Answer 11

SLE, myositises

Question 12

disease resistant to non-depolarizing NMBA

Answer 12

burns, spinal cord injury, CVA, prolonged immobility, multiple sclerosis, CP, tetanus/botulism

Question 13

disease sensitive to non-depolarizing NMBA

Answer 13

myasthenia gravis (fewer AchR), lamber-eaton (less Ach released), ALS, SLE, myositises, Guillain-Barre, duchenne muscular dystrophy

Question 14

surgeries to avoid NMBA

Answer 14

axillary node dissection, ENT cases near nerves, neuro-monitoring