Neurology S5

Question 1

Overactivity in the indirect pathway is a major factor in —— -

underactivity in the indirect pathway is a major factor in :

Huntington disease

Answer 1

Overactivity in the indirect pathway is a major factor in Parkinsonian signs, while underactivity in the indirect pathway is a major factor in hyperkinetic disorders such as hemiballism (violent involuntary throwing movements of the limb after a lesion in the contralateral subthalamic nucleus), Huntington disease (which is an autosomal dominant hyperkinetic disorder characterized by chorea, dementia and behavioral disturbance).