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Royal College Peds 2021 > Neurology COPY > Flashcards

Neurology COPY Flashcards

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1
Q

What do you know about age of onset and sex of kids with absence seizures?

A

Eped: children >5 years, girls>boys,

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2
Q

What is the modified sarnat score for neonatal HIE?

A
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3
Q

What are the clinical features of tension headaches?

A

-dull/aching, bilateral: frontal or band-like

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4
Q

Acute treatment of tension headaches?

A
  1. Reassurance + rest + + Treat stress/anxiety/depression
  2. Wean caffeine
  3. Tylenol/ibuprofen

…Avoid opioids when possible

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5
Q

Migraine Epedimiology?

A
  • Most frequent type of headache in children:
  • 5% of school aged children
  • 50% spont remission after age 10

Aura = cortical spreading depression (CSD)

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6
Q

What are the 5 criteria for Migraine without aura?

A

No of attacks, duration, headache features, asociated Sx and no other Dx likely

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7
Q

How many attacks do you need to have to Dx Migraine with aura?

A

A. . >2 attacks

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8
Q

How do you abort migraine?

A
  1. Rest in dark, quiet room
  2. ibuprofen probably more effective. Acetaminophen monotherapy not recommended
  3. Gravol or IV metaclopromide for nausea
  4. Triptans (eg sumatriptan) = 5-HT agonists to abort if above ineffective in adolescents

N.B. Caffeine not recommended in children

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9
Q

Non-pharm prophylaxis: Migraine prevention?

A

Non-pharm prophylaxis:

1. Food diary, avoid TRIGGERS, Nutraceuticals (magnesium, riboflavin, butterbur)

2. Behavior mgmt: biofeedback, self-hypnosis, relaxation technique

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10
Q

How do you treat Status migrainosus?

A

Status migrainosus (>3 d):

  1. Dark, quiet room, IVF, sedation
  2. IV NSAID (Keterolac)
  3. Chlorpromazine or Prochlorperazine IV is highly effective
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11
Q

What is the Epid of cluster headaches?

(Trigeminal Autonomic Cephalalgias)

A

Epid: Mainly boys, onset after 10y, rare

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12
Q

How doyou treat cluster headaches?

A

Acute:

  1. Oxygen inhalation
  2. Triptans
  3. Steroids

Chronic

Lithium

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13
Q

What are the ICP Pseudotumour cerebri details?

A

Characterized by increased ICP

  • > 200 mm H2O in infants;
  • > 250 mm H2O in children
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14
Q

Broad classes of Etiology of pseudotumour cerebri ?

A

MIDHV…idiot

Metabolic:

Infectious:

Drugs:

Hematologic:

Vascular:“

idiopathic intracranial hypertension”

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15
Q

General management of PTC?

A
  1. identification and treatment of underlying cause
    - If due to obesity -weight loss
    - If due to drug stop drug!
  2. For most patients, repeated follow-up and monitoring of visual acuity is all that is required
  3. The initial lumbar tap may that follows a CT/MRI is diagnostic and can be therapeutic
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16
Q

What do you know about Epedimiology of Infantile spasms (West syndrome)?

A

Epid: Peak onset - 3 to 8 months, 90% < 1 year.

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17
Q

What do you know about Cyanotic breath-holding spells age of onset and disappearance?

A

Peak - 2 yr of age, abate by 5-8 yr , rare < 6 mths

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18
Q

What do you know about triggers for Pallid breath-holding spells?

A

painful experience, such as falling and striking the head or a sudden startle.

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19
Q

What do you know about Masturbation/self-stimulating behavior Eped- age, sex and situations?

A

GIRLS, 2 months and 3 yo, when bored

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20
Q

Other causes of headaches

A

Medication overuse - OTC medications more than 3 times per week for 3 mths

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21
Q

Indications for Neuroimaging in headaches?

A
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22
Q

Indications for Neuroimaging - questionable v1

A
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23
Q

Indications for Neuroimaging - questionable v2

A
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24
Q

What are the features of floppy baby with ecntral hypotonia?

A
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25
Q

What are the causes for Central Hypotonia?

A
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26
Q

What are the features of Peripheral Hypotonia?

A
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27
Q

What are the causes of Peripheral Hypotonia?

A
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28
Q

Juvenile myoclonic epilepsy (“of Janz”) Epedimiology?

A

Eped: adolescence, AD , chromosome 6 with variable penetrance

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29
Q

What no of attacks do you need to Dx migraine without aura?

A

> 5

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30
Q

What duration is needed to Dx migraine without aura?

A

1-72 hrs

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31
Q

What headache features are needed to Dx migraine without aura?

A

C. > 2 of:

  1. Unilateral
  2. Pulsating quality
  3. Mod or severe intensity
  4. Aggravation by routine px activity
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32
Q

What other features are needed to Dx migraine without aura?

A

D. During HA, > 1 of

  • Nausea, vx
  • Photo/phonophobia

E. Not attributable to another disorder

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33
Q

What % of Px with migraine without aura have a family Hx?

A

90%

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34
Q

What are the clical features of abscence seizures?

A

no aura

-

  • no post-ictal state.
  • Can provokein the office by hyperventilation.
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35
Q

What is the treatment for abscence seizures?

A
  1. 1st line Ethosuximide.
  2. If GTC..Valproic

Recent peds in review series on seizure types and management

· Since 40-50% of children with absence seizures will have GTC seizures, VPA optimal choice as it covers for GTC as well.

· Carbamazepine first-line for partial seizures

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36
Q

What are the associations with tension headaches?

A
  • -NO nausea/vomiting
  • assoc with anxiety/depression
  • onset later in day (AM rare)..-wax/wane
37
Q

How do you Dx tension heachaes?

A
  • Dx by exlusion Hx and exam
  • In teeenagers, difficult to DDx from migraine
38
Q

Which form of migraine os more common..no aura or with aura (classic)?

A

No aura

39
Q

When does the aura present before a migraine?

A

Migraine HA begins during/within 1h

40
Q

Fx of Typical aura?

A
  • Visual aberrations/dysesthesias/speech (5-60 min)
  • retinal migraine variant: blindness/scotoma
41
Q

Fx of Hemiplegic Aura?

A

Unilateral sensory/motor signs, ±aphasia

42
Q

Fx of Basilar-type aura?

A

Vertigo, ataxia, tinnitus, vision change

43
Q

What are the 3 broad Dx features of migraine with aura?

A

> 2 attacks, aura, Not attributed to another disorder

44
Q

What are the triggers to migraine?

A

stress, fatigue, anxiety, exercise, menstrual, food

45
Q

Indications for Drug treatment to prevent migraine?

A

For > 2-4 HA per month or unable to attend school regularly

•

46
Q

What are the drug Rx for migraine?

A
  1. Flunarazine (CCB) 5 mg daily (only proven therapy)
  2. Propranolol (BB)
  3. Others: Anticonvulsants (Topamax), amitriptyline, cyproheptadine, Sandomigran (Pizotifen)
47
Q

What is the Modified Raskin Protocol (adults) For status migainosus?

A

-DHE (dihydroergotamine), Metoclopromide, ±steroids

48
Q

What is the pattern of attacks with cluster headaches?

A
  • Cluster of daily attacks for 2-12 wk,
  • few x per year,
  • seasonal
49
Q

What are the symptoms of cluster headaches?

A
  • Unilateral, sharp/burning,
  • worse supine,
50
Q

Associated Sx of cluster headaches?

A
  • assoc with coryza,
  • autonomic phenomena (tearing & sweating),
51
Q

Eye Sx of cluster headaches?

A

periorbital edema,

ipsilateral ptosis

-conjunctivitis,

52
Q

Pseudotumor cerebri CSF details?

A

Normal CSF cell count, CSF protein,

53
Q

Pseudotumor cerebri MRI details?

A

normal ventricular size/anatomy/position

54
Q

Pathophysiology of Pseudotumor cerebri?

A

abnormal CSF production, ¯absorption, edema, abnormal vasomotor control, venous obstruction

55
Q

Metabolic pseudotumour cerebri ?

A

: galactosemia, hypoPTH, prolonged steroids, Vitamin A, Addison, pregnancy, etc

56
Q

Infectious pseudotumour cerebri ?

A

: roseola, sinusiti, OM, mastoiditis, Guillan-Barré

57
Q

Drugs pseudotumour cerebri ?

A

: doxycycline, tetracycline, isotretinoin

58
Q

Hematologic pseudotumour cerebri ?

A

: polycythemia, hemolytic anemia, iron-deficiency

59
Q

Vascular - pseudotumour cerebri ?

A

: Venous sinus thrombosis

60
Q

Clicial Fx of PTC?

A
  1. Headache (most frequent)-Pressure type (e.g., am, worse after laying down, better with standing, papilledema)
  2. Vomiting also occurs (but not as bad as for posterior fossa tumour)
  3. Diplopia (secondary to paralysis of abducens (CN VI) nerve)
  4. Most patients are alert and lack constitutional symptoms
61
Q

Pseudotumor cerebri exam signs?

A
  1. bulging fontanelle;

2.percussion of skull = ‘cracked pot sound’

  1. papilledema is most consistent sign in a child beyond infancy
  2. …N.B. a focal neurological sign suggests a process other than pseudotumour cerebri

Complications:

62
Q

Pseudotumor cerebri cplxns?

A

Optic atrophy and blindness

63
Q

Preventative Rx of tension headaches

A

• Non-pharmacological (regular meals & sleep, avoid

caffeine, avoid food triggers, exercise)

• Limit use of abortive therapies to <15 x per month

64
Q

Medications for PTC?

A
  1. Acetazolamide, furosemide
  2. Corticosteroid
  3. Considering treating sinus thrombosis with anticoagulation

**Keep in mind a slow-growing tumour or obstruction of a venous sinus

65
Q

Clinical Fx of infantile spasms?

A

Clin: brief Frequent clusters of flexor, extensor, or mixed spasms

(neck, trunk, arm muscles, … phase of sustained muscle contraction lasting 2 - 10 seconds. Mostly when awakening from or going to sleep. Many clusters occur each day.

66
Q

Inv of infantile spasms?

A
  • waking state,hypsarrhythmia, is dramatically abnormal, consisting of high-voltageslow waves, spikes, and polyspikesaccompanied by background disorganization.
  • During sleep-Burst suppression patterns.
67
Q

Infantile spasms mimics?

A

1.Infantile colic

with flexion of thighs and crying Infantile spasms have a poor prognosis. The etiology is not determined in 40% of children.

68
Q

Etiology/Progx of infantile spasms?

A
  1. Idiopathic (40% N development < fits) has a better response to therapy, 40% have a good IQ. Etiology is determined in 60% (Table 181-4).
  2. symptomatic group: Poor response to Rx and lower IQ (Tuberous sclerosisor Downs)
69
Q

Rx of infantile spasms?

A
  1. vigabatrin- visual field deficits (retinal toxicity)
  2. ACTH, oral prednisone (S/E-Irritability, , hypertension, glycosuria, infections, adrenal axis effects
70
Q

What is the nromal trigger for Cyanotic breatholding spells?

A

TRIGGER: Usually predictable and is always provoked by upsetting or scolding an infant.

71
Q

Clinical Sx of Cyanotic breatholding spells

A

brief, shrill cry, forced expiration and apnea.

  • cyanosis and LOC , -/- GTC fits, opisthotonos, and bradycardia, may be repeated within few hrs-
72
Q

Cyanotic breatholding spells Inv?

A

TESTS: (EEG) is normal.

-

73
Q

Cyanotic breatholding spells management?

A
  1. support and reassurance, be consistentand not reinforce the child’s behavior after the child recovers
  2. placing the child in bed NOT cuddle, play, or hold the child for a given period of time until recovery is complete
  3. consider treatment with iron supplementation
74
Q

Cyanotic breatholding spells

A
75
Q

Pallid breatholding spell Sx and Inv?

A

EVENT:

apnea, LOC, becomes pale and hypotonic, +/- GTC

-Bradycardia with periods of asystole of longer than 2 sec may be recorded.

TESTS EEG is normal.

76
Q

Pallid Breatholding spells management

A
  1. conservative measures as for cyanotic spells
  2. trial of atropine sulfate 0.01 mg/kg/24hr in divided doses with a maximum daily dose of 0.4 mg,which increases the heart rate by blocking the vagus nerve, may be considered in refractory cases.

N.B. Atropine should not be prescribed during very hot weather because an episode of hyperpyrexia may be initiated

77
Q

Self stimulation Sx?

A
  1. Repetitive stereotyped episodes:..Sudden onset, usually persists for minutes
  2. Tonic posturing with copulatory movements, adduction of thighs
  3. Without manual stimulation of genitali
  4. Autonomic: Flushed skin, perspiring, may grunt or breathe irregularly
  5. NO LOC
78
Q

Self stimulation management - exam?

A

looks for evidence of sexual abuse or abnormalities of the perineum

79
Q

Self stimulation management?

A

Reassurance - will subside by 3 years of age, no specific therapy

80
Q

What do you know about Benign focal epilepsy - Epedimiology?

Age onset, Incidence, % of afebrile efits, Fam Hx

A
  • Age 5 and 10 years
  • incidence may be 21 per 100,000
  • 16% of all afebrile seizures
  • FamHx -13%

N.B…..

Clinc:

  • focal seizure- face and arm
  • during sleep or on awakening in more than half of patients.
  • abnormal movementor sensationaround the face and mouth with droolingand a rhythmic guttural sound. Speechand swallowingare impaired.
  • Usually only have seizures at night

• May have less than 10 events

EEG: -epileptiform activity in centro-temporal regions (either unilateral or bilateral)

Mangt/Progx:

  1. May need anticonvulsant therapy- Keppra (levetiracetam) appears to be best
  2. IQ and brain MRI normal
  3. resolves after puberty.
81
Q

What do you know about Benign focal epilepsy - clinical Sx

A
  1. focal seizure- face and arm
  2. abnormal movement or sensation around the face and mouth with drooling and a rhythmic guttural sound.
  3. Speech and swallowing are impaired.

EEG: -epileptiform activity in centro-temporal regions (either unilateral or bilateral)

Mangt/Progx:

  1. May need anticonvulsant therapy- Keppra (levetiracetam) appears to be best
  2. IQ and brain MRI normal
  3. resolves after puberty.
82
Q

What do you know about Benign focal epilepsy - when occur and number of events

A
  • May have less than 10 events
  • Usually only have seizures at night, during sleep or on awakening in more than half of patients.
83
Q

What do you know about Benign focal epilepsy- Inv?

A

EEG: -epileptiform activity in centro-temporal regions (either unilateral or bilateral) with centro temporal spikes

84
Q

Bening focal epilepsy management + prognosis?

A
  1. May need anticonvulsant therapy- Keppra (levetiracetam) appears to be best
  2. IQ and brain MRI normal
  3. Resolves after puberty.
85
Q

Prognosis in absence epilepsy?

A
  1. 60% fit free 9 yrs after seizure onset
  2. Non-remitters may go onto Juvenile Myoclonic epilepsy

-

86
Q

What are the factors increasing chance of no remission in absence epilepsy?

A
  1. Cognitive difficulties at onset
  2. absence Status epilepticus before or during Rx
  3. GTC or Myoclonic fits after Rx onset
  4. Abnormal background on initial EEG
  5. Hx generalized fits in 1st degree relatives
87
Q

Juvenile myoclonic epilepsy- clincial Fx?

A

Absence, generalized tonic or clonic, and myoclonic seizures.

88
Q

Juvenile myoclonic epilepsy- Mangt?

A

valproic acid, but therapy must be maintained for life.

89
Q

When does Juvenile myoclonic epilepsy occur?

A

morning myoclonus occurring predominantly within 90 minutes of awakening.

Royal College Peds 2021 (55 decks)

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