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Pharmacology M > Neurology > Flashcards

Neurology Flashcards

1
Q

EA Carbamazepine

A 
Aplastic anemia, agranolocytosis
Ataxia
Diplopia
Liver toxicity
Teratogenic (clef palate/lip,Spina bifida)
Induction of cytochrome P450
SIADH
SJS
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2
Q

EA Etusuximide

A 
F-Faigue
G-GI distress
H-Headache
I-tching
J- SJS
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3
Q

Use: Postherpetic neuralgia

Peripheral neuropathy

A

Gabapentin

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4
Q

EA:Hemaphagocytic lymphohistiocytosis

SJS

A

Lamotrigine

Blocks Na+ channel
Inhibits release glutamate

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5
Q

EA: Neuropsychiatric symptoms (personality change)

A

Levetiracetam

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6
Q

SV2A receptor blocker

Modulate GABA, glutamate release, inhibit Ca++ channels

A

Levetiracetam

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7
Q

EA Phenytoin

A 
P450 induction
Hirsutism
Enlarged gums
Nystagmus
Yellow brown skin
Teratogenicity
Osteopenia
Inhibited pholate absorption
SLE like syndrome
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8
Q

Use: Mioclonic seizures

A

Valproic acid

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9
Q

EA Valproic acid

A 
Pancreatitis 
Teratogenic: Neural tube defect
Tremor
Weight gain
GI distress
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10
Q

Irreversible GABA transaminase inhibitor

A

Vigabatrin

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11
Q

EA: Visual loss

A

Vigabatrin

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12
Q

Contraindicated in porphyria

A

Barbiturates

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13
Q

Short acting BZ

A 
ATOM
Alprazolam
Triazolam
Oxazepam
Midazolam
**Higher adictive potential
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14
Q

BZ for status epilepticus

A

Lorazepam
Midazolam
Diacepam

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15
Q

BZ in liver disease

A

Lorazepam
Oxacepam
Temazepam

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16
Q

Suvorexant

A

Hypocretin (orexin) receptor antagonist

17
Q

AChE inhibitor

A

Donepezilo
Rivastigmine
Galantamine
Use: Alzheimer

18
Q

NMDA antagonist

A

Memantine

Use: Alzzheimer

19
Q

Use: ALS

Increases survival

A

Riluzole

Reduces glutamate excitoxicity

20
Q

Use: hungtinton disease

A

Tetrabenazine

Inhibits VMAT

21
Q

Dantrolene

A

Rianodine receptor antagonist

Use: Malignant hyperthermia, neuroleptic malignant syndrome

22
Q

Inhaled anesthesics

A 
"ANE"
Desflurane
Halothane
Enflurane
Isoflurane
Sevoflurane
Methoxyflurane
23
Q

IV anesthesics

A

Propofol
Midazolam
Ketamine-NMDA antagonist
Thiopental

24
Q

Local anethesics - amides

A

LIdocaIne
BupIvacaIne
RopIvacIne

25
Q

Order of neuron blockade

A

Small myelinizated, small unmielinizated, large myelinated, laage unmyelinated

Pain, temperature, touch, pressure

26
Q

EA: severe cardiovascular toxicity

A

BupIvacaIne

27
Q

EA: Metahemoglobinemia

A

Benzocaine

28
Q

Local anesthesics- ester

A

Procaine
Tetracaine
Benzocaine
Chlorprocaine

29
Q

Use of Neuromuscular blockade

A

Muscle paralysis in surgery or mechanical ventilation

Selective for Nm at neuromuscular junction but not autonomic Nn

30
Q

Succynylcholine

A

Depolarizing neuromuscular blockade
Strong ACh receptor agonist—-sustained depolarization
Reversal of blockade: Phase II—cholinesterase inhibitor

31
Q

Nodepolarizing neuromuscular blocking drugs

A

AtraCUrium, PanCUronium, Ach
Competitive Ach antagonist
Reversal of blokade: cholinesterase inhibitors + anticholinergics (glycopyrrolate, atrhopine)

32
Q

Neostigmine, edrophonium

A

cholinesterase inhibitors

33
Q

Baclofen

A

GABAb receptor aagonist

Use: muscle spasticity, dystonia, MS

34
Q

Use: MS

A

Baclofen, Tizanidine

35
Q

Use ALS; α 2 agonist

A

Tizanidine

36
Q 
Opioids
Full agonists
Partial agonist
Mixed agonist/Antagonist
Antagonist
A
  1. Morphine, heroin, meperidine, t¿methadone, codeine, fentanyl
  2. Buprenorphine
  3. Nalbuphine, pentazocine, butorphanol
  4. Naloxone, naltrexone, methylnaltrexone
37
Q

Severe pain (migraine, labor)

A

Butorphanol
K-opioid: agonist
u-opioid: partial agonist

38
Q

Tramadol

A

Inhibits reuptake of seronotin and NE
EA: decreases seizure thershold
Use: chronic pain

39
Q

Glaucoma therapy:

  1. B-blockers
  2. α agonists
  3. Diuretics
  4. Prostaglandins
  5. Cholinomimetics M3
A
  1. ↓ synthesis humor aqueus: betaxeolol, carteolol
  2. ↓ synthesis humor aqueus ; ↓ synthesis humor aqueus by vasoconstriction (epinephrine)
  3. ↓ synthesis humor aqueus by inbition of carbonic anhydrase
  4. ↑ drainage; ↓ resistance of flow through uveoscleral pathway
  5. ↑ drainage; conraction of ciliary muscle and openind of trabecular meshwork

Pharmacology M (5 decks)

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