MSK

Question 1

Colchicine

Answer 1

Acute Gout and prophilactic

Inhibit microtubule polimerization: impairing neutrophil quimiotaxis and degranulation

Question 2

Febuxostat

Answer 2

Chronic gout

Inhibit xanthine oxidase

Question 3

Allopurinol

Answer 3

Competitive inhibitor of xanthine oxidase

Hypoxanthine to xanthine

Question 4

Etanercep

Answer 4

Fusion protein (decoy receptor for TNF-et + IgG1 Fe)
Use: AR, ankylosing Spondylitys, psoriasis

Question 5

Infliximab
Adalimumab
Golimumab
Certolizumab

Answer 5

Anti-TNF-et monoclonal antibody.

Use: inflammatory bowel disease, AR, ankylosing Spondylitys, psoriasis,

Question 6

Meloxicam
Piroxicam
Diclofenac
Ketorolac

Answer 6

Inhibit COX-I and COX-2

EA: nephritis interstitial, gastric ulcer, renal ischemia, aplastic anemia

Question 7

Indometacin

Answer 7

Inhibit COX-I and COX-2

Use: Closes PDA

Question 8

Leflunomide

Answer 8

Reversibly inhibits dihydroorotate dehydrogenase, prevent pyrimidine synthesis
Use: AR, psoriatic arthritis

Question 9

Alendronate
Ibandronate
Risedronate
Zoledronate

Answer 9

Use: Osteoporosis, hypercalcemia, Paget disease of bone, metastatic bone disease, osteogenesis
imperfecta.A: Esophagitis, osteonecrosis of jaw, atypical femoral fracture

Question 10

Teriparatide

Answer 10

Recombinant PTH analog, osteoblastic activity

Oseoporosis, increases bone growth

Question 11

Aspirin

Answer 11

Irreversibly inhibits cyclooxygenase (both COX-I and COX-2)
Increases bleeding time
AE:Acute kidney injury, interstitial nephritis, GI bleeding

Question 12

Reye syndrome

Answer 12

When aspirin is used for viral infection

In children

Question 13

Increases uterine tone

Answer 13

PGE2: Dinoprostone
PGF2Alpha: Carboprost

Question 14

Reduces vascular tone

Answer 14

PGE1: alprostadil

Question 15

Decreases platelet aggregation and vascular tone

Answer 15

PGI2: Epoprostenol