Neurology Flashcards

1
Q

What are febrile convulsions? (1)

What age group of children are normally affected? (1)

A

Febrile convulsions are seizures provoked by fever in otherwise normal children.
They typically occur between the ages of 6 months and 5 years and are seen in 3% of children.

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2
Q

How long should a febrile convulsion last before the parent calls 999? (1)
What type of seizure activity is usually seen? (1)

A

5 minutes - put in recovery position and call 999

Tonic or Tonic-clonic

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3
Q

A child has had a febrile convulsion and the mother is concerned about further episodes. What is the chance of a further febrile convulsion? (1)

A

33% (1/3) More if positive FH

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4
Q

What is the most commonly form of epilepsy seen in children?
Name 2 common triggers?
Name 2 commonly used medications for this type of seizure.
What percentage of children will be free from this type of. Epilepsy by 16 years old?

A

Absence seizures
Stress, hyperventilation
Sodium valproate, ethosuxamide
90-95% seizure free by adulthood

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5
Q

What is benign rolandic seizures and what age group are ost commonly affected? (2)

A

Form of childhood epilepsy that occurs in 4-12 year olds.

Typically seizures are partial and occur at night

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6
Q

Name 3 causes of microcephaly? (3)

A

Normal variation, congenital infection, craniosyntosis, syndromic eg patau, foetal alcohol syndrome, perinatal brain injury eg HIE

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7
Q

Define cerebral palsy. (2)

What are the 3 types of causation and give an example of each. (3)

A
Non degenerative brain lesions with abnormal movement and posture.
Ante natal (80%) TORCH infection
Peri natal (10%) Birth asphyxia
Post natal (10%) intraventricular haemorrhage, head trauma, meningitis
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8
Q

What are the 3 classifications of cerebral palsy? (3)

clue: types not classification of causes.

A

Spastic - pyramidal tracts affected - UMN signs
Ataxic - (extrapyramidal) cerebellum affected - poor balance, delayed motor milestones, hypotonia
Dyskinetic - (extrapyramidal) basal ganglia affected - chorea, athetosis, dystonia, hypotonia, delayed motor milestones

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9
Q

How should cerebral palsy be managed? (2)

A

Conservatively - MDT, parent/patient education, support groups
Medically - Baclofen, Botox, Hyoscine for secretions, treat complications

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10
Q

What is meningitis? (2)

A

Infection of the subarachnoid space and associated inflammation of the meninges.

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11
Q

Name 3 causes of meningitis. (3)

A

0-2 month - Group B streptococcus, gram negative bacilli e.g. e coli
1m+ neisseria meningitidis (meningococcus), streptococcus pneumoniae, HiB
Any age - mycobacterium tuberculosis
VIRAL - enteroviruses, CMV

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12
Q

Name 3 risk factors that can put a child a greater risk of developing meningitis. (3)

A

impaired immunity - young, splenic defect (SCD), defects of complement system
low SES - overcrowding, poverty.

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13
Q

What symptoms in a history would make you suspicious of meningitis in a neonate and in a child? (4)

A

Neonate - fever, irritability, lethargy, seizures, shrill cry, rash
Child - fever, headache, neck stiffness, decreasing GCS, nausea, vomiting, photophobia, anorexia, rash or seizures.

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14
Q

What is Kernig’s sign? (1)

A

Sign of meningeal irritation - supine, knee and hip are flexed and there is pain on extending leg

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15
Q

Name 3 signs of raised ICP. (3)

A

Papilloedema, decreased consciousness, focal neurology (6th nerve palsy), Cushing reflex (high BP, low HR), decerebrate posturing (extended arms, internally rotated)

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16
Q

Descrive the rash that is typically associated with meningococcal infection. (2)

A

Purpuric or petechial rash usually non-blanching.

17
Q

What is a full septic screen? (5)

A

FBC, blood, urine and CSF cultures, CXR

18
Q

How would CSF help to differentiate between a bacterial and viral cause of meningitis? (3)

A

Bacterial - neutrophils, high protein, low glucose

Viral - neutrophils early then lymphocytes, normal/mildly elevated protein, normal glucose, PCR can diagnose

19
Q

What is the management of suspected meningitis? (3)

A

Full septic screen
Empirical antibiotics - ceftriaxone
Supportive care - fluids, analgesics, antipyretics
Notification - meningitis is notifiable disease

20
Q

Give 3 complications of meningitis. (3)

A

During infection: seizures, cerebral oedema, circulatory shock, DIC
Post-infection: Hearing loss, visual impairment, cerebral palsy, hydrocephalus, cerebral abscess, learning disability, subdural effusions (resolve spontaneously)

21
Q

Which form of meningitis has the best prognosis? (1)

A

Viral: 95% complete recovery with no neuro probe

In meningococcal infection with septicaemia the mortality is 20-50%

22
Q

Name 4 potential causes of seizures in children. (4)

A

Febrile convulsions, epilepsy, hypoglycaemia, hypocalcaemia, hypomagnesia, hyponatraemia, hypernatraemia, uraemia, HIE, meningitis, space occupying lesion, poisoning, encephalitis

23
Q

What is Todd’s paralysis? (1)

A

Focal weakness of part of the body following a seizure

24
Q

Define status epilepticus. (1)

A

Seizure activity lasting over 30 minutes

25
Q

Name 3 causes of infantile spasms. (3)

A

Idiopathic (normal development and normal CT)
Prenatal: TORCH infection, tuberous sclerosis
Perinatal: birth asphyxia
Postnatal: meningitis, encephalitis, head trauma

26
Q

Descrive infantile spasms. (3)

A

Occur between 3 and 12months old.
Can be flexor or extensor spasms of neck, trunk, arms and legs or mixed.
May be preceded by a cry, and mainly occur when drowsy or awakening
Associated with developmental delay

27
Q

Describe the floppy infant when lying supine or on pulled to sit. (1)

A

Marked hypotonia causes…
Lying in frog position
Head lag

28
Q

Name 2 systemic, central and peripheral causes of a floppy infant. (6)

A

Systemic: hypothyroidism, infection, inborn error of metabolism, congenital lax ligaments
Central: Encephalopathy, Chromosomal abnormalities eg Downs (21), Prader-Willi (15), Ataxic cerebral palsy
Peripheral:
Spinal cord; compression/transection
Anterior horn cell; rare autosomal recessive disease
Neuromuscular junction; myasthenia gravis
Peripheral nerve; guillain-barre
Muscle; myotonic dystrophy