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Boards: Other Topics (Endocrine, CPR, Euthanasia, etc) > Neurology > Flashcards

Neurology Flashcards

1
Q

Peripheral Nervous System

A

○ Sensory portion: specialized sensory receptors and organs that detect the state of the body or its surroundings

○ Afferent (to brain), efferent (to body/affected organ) nerve fibers that conduct impulses between receptors, sensory organs, CNS and peripheral effectors (skeletal muscle - Motor component)

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2
Q

Central Nervous System

A
  1. Brain
  2. Spinal Cord
  3. Autonomic NS - PSNS, SNS
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3
Q

General Function of Brain

A

stores information, generates thoughts
■ reactions in response to sensation
● Signals originate in Motor Nuclei → transmitted through the motor tracts within the CNS → Motor portion of PNS

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4
Q

Parts of the Brain

A
  1. Forebrain
  2. Brainstem
  3. Grey Matter
  4. White matter
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5
Q

Forebrain Components

A
  1. Telencephalon (cerebrum)
  2. Diencephalon
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6
Q

Components of Diencephalon

A

Diencephalon = forebrain

Thalamus, Hypothalamus

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7
Q

Components of Telencephalon

A

Forebrain
○ 2 hemispheres
○ Rhinencephalon
○ Corpus Callosum
○ Limbic System
○ Hippocampus
○ Ventriculus lateralis (lateral ventricle, ventriculus III (third ventricle)
○ Corpus Amygdaloideum

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8
Q

Components of the Brainstem

A
  1. Mesencephalon
  2. Metencephalon
  3. Myelencephalon
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9
Q

Mesencephalon

A

Tegmentum mesencephalic

Brainstem, midbrain

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10
Q

Metencephalon

A

Ventriculus IV
Pons
Cerebellum

Brainstem, hindbrain

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11
Q

Myelencephalon

A

Brain, hindbrain

Medulla oblongata

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12
Q

Grey Matter

A

Neuronal cell bodies
Axons with little myelination

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13
Q

White Matter

A

Myelinated Axons

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14
Q

Mnemonic for Cranial Nerve Functions (Sensory vs motor vs both)

A

Some
Say
Marry
Money
But
My
Brother
Says
Big
Brains
Matter
More

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15
Q

CN I

A

Olfactory = sensory

■ Function: Smell
■ Arises from primary olfactory cortex (temporal lobe)
■ Neurons from olfactory tracts → run to olfactory bulb (above cribriform plate of ethmoid bone)
■ Receives sensory information from nasal cavity’s olfactory neurons

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16
Q

CN II

A

Optic N = sensory

■ Function: Vision
■ Emerge from eye retinas
■ Pass through optic canal, unite at optic chiasm (partial decussation) → optic nerve fibers from optic tracts → synapse at different nuclei
● Suprachiasmatic nucleus in thalamus (sleep-wake cycle)
● Pretectal nucleus in midbrain (eye reflexes)
● Lateral geniculate nucleus in thalamus (sight)

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17
Q

CN III

A

Occulomotor N = Motor

■ Function: eye movement
■ Arises from ventral midbrain; runs through superior orbital fissure to eye
■ Splits into superior and inferior branch

● With proprioception - controls pupil constriction (sphincter pupillae), visual focusing (cilliaris) via ciliary ganglion

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18
Q

Superior Branch of CN III

A

Levator palpebrae superioris ( raises upper eyelid), superior rectus (elevates eye)

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19
Q

Inferior Branch of CN III

A

inferior oblique (abducts eyeball), medial rectus (adducts eyeball)

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20
Q

CN II synapse at what nuclei?

A

Suprachiasmatic nucleus in thalamus (sleep-wake cycle)
● Pretectal nucleus in midbrain (eye reflexes)
● Lateral geniculate nucleus in thalamus (sight)

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21
Q

CN IV

A

Trochlear Nerve (Primary motor, some sensory)

■ Function: eyeball movement
■ Arises from dorsal midbrain, runs around midbrain, follows oculomotor nerve through superior orbital fissure
■ Innervates superior oblique muscles (abducts, depresses, internally rotates eyeball)

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22
Q

CN V

A

Trigeminal Nerve (sensory, motor)

■ Function: facial movement, chewing, temperature, touch, pain
■ Emerges from pons; travels to trigeminal ganglion
■ Splits into ophthalmic, maxillary and mandibular nerves

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23
Q

Orbital Br CN V

A

exits through superior orbital fissure, gives sensory innervation to upper eyelid, nose, forehead , scalp

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24
Q

Maxillary Br CN V

A

Nerve exits through the foramen rotundum, gives sensory innervation to maxilla, nasal cavity, palate, cheeks skin

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25
Q

Mandibular Br CN V

A

exits through foramen ovale, gives sensory innervation to tongue (NOT taste), lower lip, lower teeth, temporal scalp; Motor innervation to chewing muscles

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26
Q

CN VI

A

Abducens nerve (motor)
■ Function: eyeball movement
■ Emerges from the pons, runs through superior orbital fissure
■ Innervates lateral rectus muscle (abduct eye)

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27
Q

CN VII

A

Facial nerve (sensory, motor)
■ Function: taste, saliva, tears, facial movement
■ Emerges from the pons, enters temporal bone through internal acoustic meatus
■ Runs within bone to geniculate ganglion
■ Splits into greater petrosal nerve, stapedius nerve, chorda tympani

Splits again into temporal, zygomatic, buccal, mandibular, cervical branches (innervating forehead, nose, cheeks, around eyes/lips, chin)

28
Q

Greater Petrosal Br of CN VII

A

autonomic fibers to lacrimal, nasal, palatine, pharyngeal glands

29
Q

Stapedius Br of CN VII

A

motor fibers to inner ear

30
Q

Chorda Tympani Br CNVII

A

sensory to taste buds of tongues anterior ⅔

31
Q

CN VIII

A

hearing, equilibrium
■ Emerges from pons, runs through internal acoustic meatus
■ Splits into cochlear, vestibular nerves

32
Q

Cochlear Br CN VIII

A

supplies hearing receptors

33
Q

Vestibular Br CN VIII

A

vestibules equilibrium receptors

34
Q

CN IX

A

Glossopharyngeal nerve (sensory/motor)
■ Function: swallowing, monitoring blood pressure/oxygen/CO2
■ Arises from Medulla; runs through jugular foramen
■ Innervates tongue, pharynx
■ Sends motor fibers to stylopharyngeus (elevates pharynx in swallowing), parasympathetic motor fibers to parotid salivary glands, sensory fibers to tongues posterior ⅓
■ Conveys information from carotid bodies chemoreceptors (Blood O2, CO2 levels), carotid sinus’ baroreceptors (blood pressure)

35
Q

CN X

A

Vagus Nerve (Sensory/Motor)
■ Function: smooth muscle control, digestive enzyme secretion
■ Arises from the medulla, runs through the jugular foramen
■ Dips down into thorax and abdomen*
■ Sends somatic motor innervation to pharynx, larynx (swallowing), PSNS fibers to heart, lungs, abdominal organs (heart rate, breathing digestion)
■ Brings sensory information from thoracic, abdominal organs, aortic arch’s baroreceptors; chemoreceptors in carotid, aortic bodies; epiglottis’ taste buds

36
Q

CN XI

A

Accessory Nerve (motor)
■ Function: swallowing; head and shoulder movement
■ Considered vagus nerve accessory
■ Forms from rootlets emerging from spinal cord; enters skull via foramen magnum, emerges from medulla, runs through jugular foramen
■ Innervates: trapezius, sternocleidomastoid (head, neck movement); carries sensory proprioceptive information from larynx/pharynx

37
Q

CN XI

A

Hypoglossal (motor)
■ Function: tongue movement, speech, swallowing
■ Arises from medulla; runs through hypoglossal foramen
■ Sends motor fibers to tongue muscles, carries sensory proprioceptive information

38
Q

Dura Mater

A

(most superficial membrane)
■ Epidural space: between ligamentum flavum and dura mater
● Contains fat, connective tissue

39
Q

Arachnoid

A

■ Subdural space: between Dura Mater and Arachnoid membrane

40
Q

Pia Mater

A

(direct contact with brain/spinal cord)
■ Subarachnoid (intrathecal) space: between the arachnoid and pia mater
● Location for spinal CSF sampling/intrathecal administration of medications

41
Q

Blood Brain Barrier

A

Anatomic and enzymatic separation that isolates cerebral blood from most brain parenchyma and CSF
■ Located at choroid plexus, brain parenchymal vessels, subarachnoid vessels, and arachnoid membrane

42
Q

Composition of BBB

A

Composed of cells connected by tight junctions
■ Restrict intracellular diffusion - force solute exchange to occur through cells
○ Prevents passage of small/moderate amounts of epi, norepi, serotonin, dopamine from blood to brain
■ *Circulating catecholamines do not significantly affect Cerebral Metabolic Rate for Oxygen (CMRO2)

43
Q

Changes with BBB Permeability

A

■ If BBB permeability increases (Intracranial hypertension, inflammation, disruption of osmosis) catecholamines can cross and cause reversible increases in CMRO2

44
Q

CSF

A

Provides hydromechanical protection of the CNS, role in brain development and influences neuronal functioning via regulation of interstitial fluid homeostasis

45
Q

CSF Production

A

Produced under enzymatic control of Carbon Anhydrase
■ Choroid plexuses in lateral, third and fourth ventricles
■ Minor volume produced as a metabolic by-product

46
Q

CSF Rate of Production

A

■ Cats: 0.02 ml/min
■ Dogs: 0.05 ml/min
■ Humans: 0.4 ml/min

47
Q

Composition of CSF vs Plasma

A

■ INCREASED Na+, Cl-, Mg2+
■ DECREASED glucose, protein, amino acids, K+ and bicarbonate

48
Q

Drainage of CSF

A

■ Absorption via cranial and spinal arachnoid villi into venous outflow system
■ Cranial and spinal nerve sheaths
■ Adventitia of cerebral arteries into the lymphatic outflow system

49
Q

Flow Dynamics, Pressure of CSF Depend on:

A

■ Arterial pulse wave
■ Respiratory waves
■ Animal posture
■ Jugular venous pressure
■ Physical effort

50
Q

Causes Decreased Formation of CSF

A

■ Arterial hypotension
■ Decreased cerebral perfusion pressure (CPP)
■ Increase in ICP
■ Administration of diuretics (Carbonic Anhydrase inhibitor; furosemide), mannitol, corticosteroids, omeprazole

51
Q

Causes Increased Formation of CSF

A

■ Anesthetics (enflurane, ketamine, halothane) may increase or augment
● Isoflurane and fentanyl may be preferable in patients with increased CSF volume

52
Q

ANS

A

Regulates the body’s internal environment - functions to maintain homeostasis

Operates on a subconscious level
–Controls visceral functions of internal organs
■ Maintenance of arterial blood pressure
■ GI motility and secretion
■ Urinary bladder emptying
■ Thermoregulation
–Rapid and intense changes in function
■ Ex: ABP can be doubled within 10-15 sec

53
Q

Control of ANS

A

Controlled by centers located in the spinal cord, brainstem and hypothalamus
○ Limbic cortex can transmit impulses to lower centers and influence autonomic control

54
Q

Afferent ANS Signals

A

enter autonomic ganglia, spinal cord, brainstem, hypothalamus
○ Elicit REFLEX responses back to organs

55
Q

Efferent ANS Signals

A

transmitted to the body through two subdivisions: Sympathetic and Parasympathetic Nervous Systems

56
Q

SNS Composition

A

■ Two paravertebral sympathetic chains of ganglia located on each side of spinal column
■ Two prevertebral ganglia (celiac and hypogastric ganglion)
■ Nerve fibers extending from the ganglia to nerve endings in the internal organs

57
Q

Location of SNS Origins

A

Sympathetic nerves originate in the spinal cord between segments T1 and L2
■ Pass into sympathetic chain then to tissues and organs

58
Q

Structure of SNS

A

Each sympathetic nerve composed of two in series: preganglionic and postganglionic
■ Preganglionic cell body lies in Internal Mediolateral Horn of spinal cord
● Fiber passes through Ventral Spinal root into corresponding spinal nerve
● Preganglionic fibers leave nerve and pass through the White Ramus into one of the ganglia of sympathetic chain

From there, can:
(1) Synapse with postganglionic neurons in the ganglion it enters
(2) Pass upwards or downwards in the chain and synapse on another ganglia
(3) Pass for variable distances through the chain, then terminate on one of the prevertebral ganglia

59
Q

SNS Postganglionic Neurons

A

originate in either a sympathetic chain ganglia or prevertebral ganglia
● Then travel to organs

60
Q

Adrenal Medulla

A

Preganglionic fibers pass without synapsing from intermediolateral horn, through sympathetic chains, through splanchnic nerves, and into medulla
○ End directly on modified neuronal cells that secrete EPI/NE norepi into bloodstream
○ Secretory cells are analogous to postganglionic neurons

61
Q

PNS

A

○ Fibers of the PNS leave the CNS through CN III, IX, X and the 2nd, and 3rd (sometimes 1st and 4th) sacral spinal nerves
○ 75% of all parasympathetic nerve fibers are in the vagus nerve (CN X)
■ Comprise cranial, cervical and thoracic parts
■ Supply parasympathetic fibers to the heart, lungs, esophagus, stomach and other abdominal viscera.

62
Q

Destination of Parasympathetic Fibers

A

○ CN VII pass to the lacrimal, nasal and submandibular glands
○ CN IX pass to the parotid gland
○ Preganglionic fibers pass uninterrupted to the organ where postganglionic neurons are located in the organ wall

63
Q

ANS Transmission

A

○ Synaptic transmission within the ANS utilizes Acetylcholine (ACh) and norepinephrine (NE)
■ ALL Preganglionic sympathetic and parasympathetic neurotransmission is CHOLINERGIC
■ Postganglionic Parasympathetic: Cholinergic
■ Postganglionic Sympathetic: Noradrenergic

64
Q

ACh

A

activates two types of cholinergic receptors: Muscarinic (M) and Nicotinic (nAChR)
■ G-protein coupled receptors
■ Belong to superfamily of ligand-gated Ion channels

65
Q

Nicotonic R

A

found in the synapses between pre- and postganglionic neurons of both the sympathetic and parasympathetic systems
■ Variety of nicotinic subunit combinations
■ Structural diversity and locations of receptors contribute to variable roles in the CNS

66
Q

Neuromuscular Transmission

A

Boards: Other Topics (Endocrine, CPR, Euthanasia, etc) (8 decks)

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