Neurological examination Flashcards
What are causes of horner’s syndrome? (6)
- carcinoma of lung apex (usually SCC)
- Neck - thyroid malignancy, taruma
- Carotid artery lesion - aneurysm, dissection, pericarotid tumour, cluster headache
- Brain stem lesions - vascular disease (Esp LMS), syringobulbia, tumour
- Retro-orbital lesions
- Syringomyelia
What are causes of anosmia?
Bilateral:
- URTI
- Meningioma of the olfactory groove (late)
- ethmoid tumours
- head trauma (including crimbriform plate #)
- meningitis
- hydrocephalus
- congenital - Kallman’s syndrome (hypogonadotrophic hypogonadism)
Unilateral:
- meningioma of the olfactory groove (early)
- Head trauma
What are causes of absent light reflex but present accomodation?
- midbrain lesion (Argyll Robertson pupil)
- Ciliary ganglion lesion (e.g. Adie’s pupil)
- Parinaud’s syndrome
- Bilateral anterior visual pathway lesions (bilateral afferent pupil deficits)
What are causes of absent convergence but intact light reflex?
- Cortical lesion - cortical blindness
2. midbrain lesions - rare
What are causes of constricted pupils?
- Horner’s syndrome
- Argyll Robertson pupil
- Pontine lesion - often bilateral, but reactive to light
- Narcotics
- Pilocarpine drops
- Old age
What are causes of dilated pupils?
- Mydriatics, atropine poisoning of cocaine
- Third nerve lesion
- Adie’s pupil
- Iridectomy, lens implant, iritis
- Post-trauma, deep coma, cerebral death
- Congenital
What is the cause and features of Adie’s pupil?
Lesion in efferent parasympathetic pathway.
- dilated pupil
- decreased/absent reaction to light (direct and consensual)
- Slow or incomplete reaction to accommodation with slow dilation afterwards
- Decreased tendon reflexes
- patients commonly young women
What are causes of Argyll Robertson pupil?
Lesion of iridodilator fibres in the midbrain:
- syphilis
- diabetes mellitus
- alcoholic midbrain degeneration (rarely)
- other midbrain lesions
What are features of Argyll Robetson pupil?
- small, irregular, unequal pupil
- nil reaction to light
- prompt reaction to accommodation
- if tabes associated, decreased reflexes
What are causes of papilloedema?
- SoL - causing raised ICP or retro-orbital mass
- Hydrocephalus (associated with enlarged ventricles)
a. obstructive - block in 3rd ventricle, aqueduct or outlet to 4th ventricle (e.g. tumour)
b. communicating
c. increased formation - choroid plexus papilloma
d. decreased absorption - tumour causing venous compression, subarachnoid space obstruction from meningitis - Benign intracranial hypertension
a. idiopathic
b. OCP
c. Addison’s disease
d. drugs - nitrofurantoin, tetracycline, vit a, steroids
e. lateral sinus thrombosis
f. head trauma - HTN - grade 4
- Central retinal vein thrombosis
- Cerebral venous sinus thrombosis
- High CSF protein level - GBS
What are causes of optic atrophy?
- Chronic papilledema or optic neuritis
- Optic nerve pressure or division
- Glaucoma
- Ischaemia
- Famililal - retinitis pigmentosa, leber’s disease, friedreich’s ataxia
What are causes of optic neuropathy?
- MS
- Toxic - ethambutol, chloroquine, nicotine, alcohol
- Metabolic - B12 def
- Ischaemia - DM, temporal arteritis, atheroma
- Familial - Leber’s disease
- Infective - infectious mononucleosis (glandular fever)
What are causes of cataract?
- Old age - senile cataract
- endocrine - DM, steroids
- Hereditary or congenital - dystrophica myotonica, refsum’s disease
- Ocular disease - glaucoma
- Irradiation
- trauma
What are causes of ptosis?
- Myasthenia gravis
- Myopathy (hereditary, congenital, mitochondrial)
- Horner’s syndrome
- CNIII palsy
- Senile ptosis, due to dehiscence of the levator palpebrae muscle
What are causes of diplopia?
Eye muscle problem:
- CN, INO
- Myasthenia, myopathy, thyroid eye disease
Nystagmus
What are causes of poor vision?
- MS
- Stroke
- Ischaemic optic neuropathy
- Pituitary lesions
- Diabetes-cataracts, retinopathy
What should be tested in a patients with ptosis or diplopia?
- pupillary response (direct, indirect, RAPD)
- EOM - puruit
- Fatigue of upgaze
- Visual fields
- Visual acuity
- Fundoscopy
- Check for weakness of other facial muscles
What should be tested in a patient with poor vision?
- Visual acuity
- Fundoscopy
- Visual fields +/- neglect
- Pupillary response - Direct, indirect, afferent pupillary defect
- EOM - pursuit