Gastrointestinal examination Flashcards
What are causes of chronic liver disease?
- Alcohol
- Viral hepatitis
- Fatty liver
- Wilson’s disease
- Haemachromatosis
- PBC
- PSC
- Autoimmune hepatitis
- Drugs
- a-1 antitrypsin deficiency
What are signs of aetiology of cirrhosis?
Hepatitis - race, tattoos, IVDU
Alcohol - parotidmegaly, dupuytren’s testicular atrophy, cerebellar signs, peripheral neuropathy
Haemachromatosis - pigmentation, 2nd, 3rd MCP arthritis, T2DM, anglo
Wilson’s - kayser-fleischer rings
Fatty liver - xanthelasma, xanthoma, obesity, loose skin folds
What are 5 signs of decompensated liver disease?
- Jaundice
- Encephalopathy - mentition, asterixis
- Portal hypertension - ascites, splenomegaly, caput medusa
- bruising
- loss of muscle bulk
(foetor hepaticus)
What are causes of decompensated liver disease?
- Infection - SBP, UTI, asp Pneumonia
- HCC
- Portal vein thrombosis
- EtOH binge
- Dehydration - diuretics, diarrhoea, vomiting
- Protein load - GI bleed
- Metabolic disturbance - hypoglycaemia
- Drugs - sedatives, diuretics
What are complications of cirrhosis?
Portal hypertension (varices, hypersplenism) HCC Coagulopathy Osteoporosis Hepatopulmonary syndrome Poor nutrition Impotence
What are causes of massive hepatomegaly?
metastases hepatocellular carcinoma myeloproliferative dis alcoholic liver dz with fatty infiltration RH failure
What are causes of moderate hepatomegaly?
haematological disease - CML, lymphoma
Fattly liver - obesity, DM, toxins
Metabolic/infiltrative - haemachromatosis, wilson’s disease
What are causes of mild hepatomegaly?
hepatitis cirrhosis biliary obstruction infiltrative - granulomatous disorders (sarcoid, amyloid) hydatid disease
What are malignant causes of hepatomegaly?
metastases
HCC
myeloproliferative
lymphoproliferative
What are fatty infiltrative causes of hepatomegaly?
alcoholic liver dz w fatty infiltration
obesity
DM
steroids
What are infectious causes of hepatomegaly?
hepatitis
hydatid disease
What are infiltrative and metabolic causes of hepatomegaly?
sarcoidodis amyloidosis haemachromatosis wilson's disease cysts of PCKD
What are obstructive causes of hepatomegaly?
right heart failure
budd chiari
biliary tract obstruction
What are causes of hepatosplenomegaly?
cirrhosis with portal hypertension myelofibrosis PCV essential thrombocytosis CML Hodkin's lymphoma Indolent lymphomas (e.g. CLL) Thalassaemia spherocytosis Viral (EBV) Endocarditis Parasitic (malaria) amyoid sarcoid SLE/RA/PAN Acromegaly Thyrotoxicosis
What are causes of a firm and irregular liver?
Cirrhosis
Metastatic disease
Hydatid disease, granuloma, amyloid, cysts, lipoidoses