Neurological Assessment Flashcards

1
Q

AVPU

A

Alert, Verbal, Pain, Unresponsive

AVPU is a simplified version of the GSC and should be done at a bare minimum

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2
Q

Full Consciousness

A

Pt. is alert attentive, follow commands, responds properly to external stimuli if asleep and once awake remain attentive

When spontaneously breathing you measure LOC through orientation to three (time, place, and person)

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3
Q

Lethargy

A

Pt. is drowsy but remains partially awaken to stimuli

Will answer and follow commands but does so slowly and inattentively

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4
Q

Obtundation

A

Difficult to arouse and needs constant stimulation to follow a simple command

Can have a verbal response of one or two words

Will drift back to sleep between stimulation

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5
Q

Stupor

A

Will arouse to vigorous and continuous stimulation, typically painful stimulus is required

Only response if trying to withdrawal from stimuli

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6
Q

Coma

A

Patient does not response to stimuli

Only response is possibly a reflux

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7
Q

Glasgow Coma Scale

A

Most widely used instrument to quantity neurological impairment

Scale goes from 3 (deep coma) to 15 (fully awake)

If intubated place a T after the score to indicate why they placed lower in the verbal response

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8
Q

GCS of 12-15

A

GCS of 12-15=Non ICU observation

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9
Q

GCS of 9-12

A

GCS of 9-12=Significant insult

GCS Less than 9=Severe coma and requires endotracheal intubation as patient is no longer awake enough to protect their own airway

If intubated place a T after the score to indicate why they placed lower in the verbal response

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10
Q

GCS Less than 9

A

GCS Less than 9=Severe coma and requires endotracheal intubation as patient is no longer awake enough to protect their own airway

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11
Q

GCS-Motor Response

A

Score of 6-Obey Commands

Score of 5-Localized Pain: Will use other appendage to stop the painful stimulus and is higher level response as opposed to withdrawal

Score of 4-Withdrawal: Attempt to pull away from painful stimuli

Score of 3-Abnormal Flexion: Arms come up and curl and toes will curl over tends to be bilateral

Score of 2-Abnormal Extension: Arms extend and tends to be a bilateral extension

Score of 1-Flaccid: No response completely limp

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12
Q

GCS-Verbal Response

A

Score of 5-Oriented

Score of 4-Confused

Score of 3-Inappropriate Words

Score of 2-Inappropriate Sounds

Score of 1-No Response

Poorly suited for patients with impaired verbal response (e.g., aphasia, hearing loss, tracheal intubation)

If intubated put a “T” after the level (e.g. 5 T) because it will affect their score as they cant score higher than 1)

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13
Q

GCS-Eye Opening Response

A

Score of 4-Spontaneously

Score of 3-To Speech

Score of 2-To Pain

Score of 1-None

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14
Q

Glossopharyngeal Nerve

A

Cranial Nerve IX

Controls-Gagging, Swallowing (Sensory), and Taste

Assessed through oral care

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15
Q

Vagus Nerves

A

Cranial Nerve X

Controls-Gagging, Swallowing, Speech and Cough

Assessed through suctioning

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16
Q

Protective Refluxes

A

Gagging is not a protective reflux becuse it can make a person aspirate

Coughing is a protective reflux

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17
Q

Phrenic Nerve

A

C3, 4, 5 keep the diaphragm alive!

C4 Breaths no more

C5 still working-enough intact that you can still breath

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18
Q

Motor Strength

A

Assess bilaterally on a scale of 0 (no movement) to 5 (full range of motion with strength)

In the unconscious patient it is assessed by applying a noxious stimuli and assessing the response

Central stimulation-sternal rub; squeeze trapezius

Peripheral stimulation (nail bed pressure) can be reflexive in nature and not a good assessment for motor function

A full motor exam is typically done by the physician and out of the scope of the RTs role

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19
Q

Decorticate

A

Abnormal Flexion

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20
Q

Decerebate

A

Abnormal Extension

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21
Q

Deep Tendon Reflex

A

Also known as the patellar reflex

Evaluates the spinal nerves and done in someone with a spinal injury

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22
Q

Superficial Reflex

A

The plantar reflex should be done in a comatose state or with injury in the lower spinal cord

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23
Q

Reflexes

A

All reflexes should be tested with someone who has a spinal injury

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24
Q

Brainstem Reflexes

A

Will be done in comatose/stupor pt. to see if brain death has occurred

Includes protective reflexes such as the gag, cough, and corneal response

Sedatives, analgesics, and paralytics can all interfere with the ability to assess and motor function and reflexes

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25
Doll's Eyes Reflex
Typically the doll's eyes reflex is elicited by turning the head of the unconscious patient while observing the eyes. The eyes will normally move as if the patient is fixating on a stationary object. If there is a negative doll's eyes reflex then the eyes remain stationary with respect to the head.
26
Pupils/Pupillary Relfex
Testing by passing a bright light in front of both open eyes and watching for movement PERRLA (Pupils Equal, Round, Reactive to Light, Accommodation) Describe size, congruency, response to light, and accommodation Will assess cranial nerves II and III
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Anisocoria
One pupil is larger than the other
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Myosis
Pontine Hemorrhage Narcotics
29
Mydriasis
Dilated Pupils Brain injury Anticholinergics
30
Mid-Position Fixed Pupils
Severe cerebral damage
31
Fixed and Dilated
Ominous sign, but there are other reasons beside brain death
32
Inadequate Sedation
Anxiety Pain Patient-vent dysynchrony Agitation self-removal of tubes/catheters Myocardial ischemia Assault of the care-provider Family dissatisfaction
33
Excessive Sedation
* Prolonged mech. ventilation and length of ICU stay * Tracheostomy * Inability to communicate * DVT * Added cost * VAP Additional testing * Cannot evaluate for delirium
34
RASS -3
Patient has any movement in response to voice but no eye contact
35
RASS -4
Patient has any movement to physical stimulation
36
RASS -5
Patient has no response to any stimulation
37
Richmond Agitation Sedation Scale (RASS)
**1. Observe the Patient-**The patient is alert, restless, or agitated (Score 0 to +4) ## Footnote **2.If Not Alert, State Patient Name and Ask to Open Eyes and Look at Speaker** **3.There is No Response to Verbal Stimulation then Physically Stimulate Pt. by Shaking Shoulder and/or Rubbing Sternum**
38
Delirium
Delirium is a sign of acute brain dysfunction and is a disturbance of consciousness with a reduced ability to sustain or shift attention Will develop over a short period of time and tends to fluctuate over the course of the day The presence of delirium indicates an underlying medical issue such as sepsis, CHF, substance intoxication, or a side effect of other medications Over sedation will prevent the assessment of delirium-This means we are unable to treat the condition that it causing it
39
Delirium Also Known As
ICU Psychosis ICU Syndrome Acute Confusional State
40
States of Delirium
Hyperactive (ICU Psychosis) Hypoactive Mixed
41
Validated Monitoring Instruments for Delirium
The Confusion Assessment for ICU (CAM-ICU) The Intensive Care Delirium Screening Checklist (**ICDSC**)-Used in Calgary Both assessment are similar Monitoring will help to optimize the delivery of sedatives and analgesics, and other psychoactive drugs, and look for other underlying medical causes to ultimately to improve patient outcomes
42
Causes of Delirium-DELIRIOUS
D-Drugs E-Enviromental Factors L-Labs I-Infection R-Respiratory Status I-Immobility O-Organ Failure U-Unrecongnized Dementia S-Shock
43
Causes of Delirium-THINK
T-Toxic situations, H-Hypoxemia I-Infection N-Nonpharmacological K-K+ or elctroylte problems
44
The Most Important Step in Delirium Management
The most important step in delirium management is **early assessmen**t
45
Management of Delirium
Identify etiology Identify risk factors Implement non-pharmacologic management (when RASS is -3) Consider pharmacologic treatment- Assess current sedation level, SATs and which meds are being used. Consider anti-psychotic meds How important is it? -“Patients whose daily sedation was interrupted had significantly fewer symptoms of PTSD after critical illness.”
46
Nonpharmacological Treatment for Delirium
* Used when RASS is ≥ 3 * Frequent reorientation of patient * Trying to keep the patient alert and oriented * Convey day, date, place, and reason for hospitalization * Update the whiteboards with caregiver names * Request placement of a clock and calendar in room * Discuss current events * Cognitively stimulating activities * Sleep protocol (day/night routines) * Normal day-night variation in illumination * Use “time out” strategy to minimize interruptions in sleep * Maintain ventilator synchrony * Promote comfort and relaxation (e.g., back care, oral care, washing face/hands, and daytime bath, massage) * Early mobility and ROM exercises * All patient should be eligible for early exercise and mobility * Timely removal of catheters, restraints… * Use of eye-glasses, hearing aids etc * Will help them to be more alert in their surroundings * Early correction of dehydration * Minimize unnecessary noises * Noise reduction strategies (e.g. minimize noise outside the room, offer white noise or earplugs) * Monitor patient’s pain level Use an objective scale FACES, BPS, VAS, CPOT, etc
47
ABCDE Protocol
Designed to standardize care processes and improve collaboration among the healthcare team Its use will help break the cycle of over sedation and prolonged ventilation ABC=Awakening and Breathing Coordination D=Delirium Non pharm Interventions E=Early Exercise and Mobility
48
Spontaneous Awakening Trial (SAT)
SAT is period of time when the sedative medications are discontinued and the patient is allowed to wake up and achieve a normal level of alertness Will prevent the accumulation of sedative drugs by giving them a chance to metabolize (decreases the risk of delirium) Provides an opportunity for more effective weaning from the ventilator
49
Spontaneous Breathing Trial and Spontaneous Awakening Trials
Often for better results when we are doing a awakening trial we will also get the patient to try and breath on their own too rather than do the trials separately When combined they may be referred to as a wake up a breath trial The combination of these two is superior to conventional sedation and spontaneous breathing trails To perform safely must make sure there are no contra indications in the patient
50
ICP
Normal ICP is **10-15 mmHg** Small fluctuations normal; variability \> 10 mmHg a bad sign At **15-20 mmHg** capillary bed is compressed and microcirculation is compromised **\>20 mmHg** is considered intracranial hypertension. At **30-35 mmHg** venous drainage is impeded and edema develops in uninjured tissue
51
ICP Monitoring Indications
Monitor patients at risk for life-threatening intracranial hypertension Monitor evidence of infection Assess effects of therapies for reducing ICP
52
CPP
CPP=MAP-ICP ## Footnote Cerebral perfusion cannot be maintained if ICP increases to within 40-50 mmHg of the MAP. When ICP ≅ MAP perfusion stops and brain dies.
53
Two Main Types of ICP Monitoring
1. **Fluid Filled Systems-**Use an external pressure like in hemodynamics (Interventricular catheter and subarachnoid bold) 2. **Solid State System**-Miniature pressure transducer inserted into the lateral ventricle, brain parenchyma, suprachnoid, or epidural space
54
Jugular Venous Oxygen Saturation (SjVO2)
Approximates the **global cerebral oxygenation** Jugular venous oxygen saturation (SjvO2) reflects the **balance between cerebral oxygen delivery and the cerebral metabolic rate of oxygen (CMRO2)** Used as a form of monitoring in a patient with TBI A catheter is inserted into the internal jugular vein and directed upwards so that the tip rests in the jugular venous bulb which is located at the base of the brain Blood samples can be drawn from here and analyzed for JvO2 (partial pressure of O2 in jugular vein) or SjVO2 (saturation level) **A normal SjVO2 is 50-75%** Can be measured continuously with a specialized catheter
55
Decreased SjvO2 can Indicate:
Decreased cerebral blood flow Cerebral hypoperfusion Possible ischemia (Can help with early diagnosis of ischemia) Increased cerebral metabolic rate (febrile, seizures) Arterial hypoxemia
56
Increased SjvO2
Reduced cerebral metabolic rate Hypothermia sedatives brain death
57
Clinical Factors Altering SjVO2
CBF can be decreased by head injury, thromboembolism, intracranial hypertension, hypotension, hyperventilation, or vasospasm. If CMRO2 remains constant or increases under these conditions, SjVO2 will decrease. Arterial hypoxia and increased CMRO2 (e.g., febrile illness, seizures) can also result in SjVO2 desaturation. Correct interpretation of increased SjVO2 requires confirmation that the catheter tip is at the jugular bulb. Reduced CMRO2 (e.g., hypothermia, sedatives), increased CBF, pathologic arterial-venous communications, and brain death may result in increased SjVO2
58
Cerebral Oximetry
A new technology that is non-invasive and determines saturation of the underlying tissue Because it is non-invasive it may have an increased value as a monitor/diagnostic uses Can be used to determine cerebral oxygenation or other locations Used often in the OR and has investigative uses in the NICU Can be trended or used for “spot checks” Just like with the SjvO2, the changes in saturation levels can indicate underlying conditions
59
Licox Monitoring
Even with normal ICP and CPP readings, cerebral hypoxia can still develop Early detection of cerebral hypoxia and impending ischemia are key to preventing secondary brain injury. The Licox system is a monitor connected to a catheter that is inserted in the brain tissue, and measures brain tissue oxygenation (PbtO2) Done in patients who have a traumatic or neurologic brain injury
60
Peripheral Nerve Stimulator: Train of Four Monitoring Twitches and ~Blockage
of Twitches Approximate % blockade 0/4 100% 1/4 90% 2/4 85% 3/4 80% 4/4 75% or less
61
Peripheral Nerve Stimulator: Train of Four Monitoring
Monitor the effects of neuromuscular blockade agents (paralytics) Electrodes placed over ulnar nerve at wrist or elbow typically (though other sites can be used) Response to stimulus is monitored by the muscle twitches and permits titration to desired effect Use can result in less medication use and allow quicker recovery Reduction of the NMBA infusion rate is indicated in order to prevent prolonged paralysis and severe weakness during ICU recovery.
62
Electroencephalography (EEG)
A recording of the brains electrical activity via the scalp Used to diagnose and monitor: Epilepsy and other seizure activity, Coma Encephalopathies, Brain death
63
Therapeutic Hyperventilation
Increasing minute volume with the goal of decreasing the PaCO2 (They technically are not hyperventilating) Know the PaCO2 (35-40) and PaO2 (80-120) TBI goals Although hyperventilation decreases ICP, cerebral perfusion pressure (CPP) is the most critical element to monitor!
64
Therapeutic Hyperventilation Indications:
Only done acutely /short-term
65
Therapeutic Hyperventilation Effects:
The low PaCO2 results in vasoconstriction of the cerebral arteries, reducing blood in the … and thus reducing the intracranial pressure
66
Therapeutic Hyperventilation Cautions:
The decreased blood flow to the brain results in decreased oxygen delivery and anoxic brain injury
67
Extra-Ventricular Drain (EVP) Procedure:
General anesthesia Cleaning of site Incision via frontal or parietal region Burr hole drilled till through the skull Underlying dura is incised Catheter inserted into ventricle (lateral) Incision closed; monitored
68
Extra-Ventricular Drain (EVP) Indications:
To allow for monitoring of ICP To reduce ICP For example, physician orders state “open EVD when ICP \>25 mmHg” When EVD is opened ICP cannot be monitored Relieve hydrocephalus (fluid/blood in the intracranial cavity)
69
Extra-Ventricular Drain (EVP) Risks:
Hemorrhage Infection Malfunction of equipment (blockage; displacement)
70
Therapeutic Hypothermia
Lowering of the patient’s body temperature to help reduce the risk of ischemic injury after a period of insufficient blood flow Most deaths caused by therapeutic hypothermia occurred during the rewarming phase of the procedure, deaths that could have been easily avoided by slow and precise rewarming. Goal temperature 32-34° C.
71
Therapeutic Hypothermia Indications
Post-cardiac arrest Stroke Traumatic brain or spinal cord injury
72
Therapeutic Hypothermia Mechanism
The benefits was though to be caused through the decrease in cellular metabolism, but now it is thought that there is more to it than that and possible mechanisms include Interrupt cell apoptosis Stabilizes cell membrane, making it more impermeable and therefore withstand unwanted ion shifting Also helps reduce reperfusion injury (damage caused by oxidative stress)
73
Therapeutic Hypothermia Risks
Arrhythmias Clotting problems Increased risk of infection Increased risk of electrolyte imbalance.
74
Therapeutic Hypothermia-Invasive
Cooling catheters (femoral vein, cooled saline; highly accurate control of temp)-Fastest, most precise and efficient Transnasal evaporative cooling (two cannula inserted in nasal cavity; sprays a cool mist)
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Therapeutic Hypothermia-Non Invasive
Water blankets, torso vest, leg wraps Cool caps Cool collars
76
Drawbacks to Sedation and Analgesic Therapy
Oversedation Failure to initiate SBTs; longer duration of mechanical ventilation Longer duration of ICU stay Impede assessment of neurological function Increases risk for delirium Numerous agent-specific adverse events
77
Sedative
Any drug that reduces CNS arousal Sleep is not the same as sedative Includes: Benzodiazepines, Nonbenzodiazepines, Barbituates
78
Hypnotic
any drug that induces sleep
79
Anxiolytic
any drug that reduces symptoms of anxiety
80
Analgesia
Any drug that reduces the sensation of pain General anesthesia has four characteristics: unconsciousness, analgesia, muscle relaxation, and depression of reflexes.
81
Anesthetics
Any drug that reduces the ability to perceive sensations
82
Pharmacological Therapies
Many drugs can have multiple effects! Effect(s) often dose dependent Can get sedation effects at low dose and full anesthetic at high dose. Most available evidence regarding sedatives and analgesics in ICU patients indicates that it may be **less important which drugs are delivered than their proper titration using goal-directed delivery** (RASS Target) to optimize patient comfort while avoiding complications such as prolonged mechanical ventilation or reintubation
83
Benzodiazepines
Used for its effects of sedative (madadala), hypnotic (valum), anxiolytic Used to treat: anxiety, agitation, insomnia, seizures/ status epilepticus, muscle spasms, alcohol withdrawal (DTs) Can be short, intermediate or long-acting (longer-acting used for anxiety)
84
Benzodiazepines Cautions
Can cause loss of airway reflexes at high doses and decreased tidal volume at lower doses
85
Benzodiazepines Reversal Agent
flumazenil (Romazicon)
86
Benzos for Sleep:
Flurazepam Triazolam (Halcion) Zopiclone (Imovane)
87
Midazolam
**Category:** Benzodiazepines **Generic Name:** Midazolam **Trade Name:** Versed **Reversal Agent:** Flumazenil (Romazicon) **Cation:** High dose loss of air reflexes, low doses decreased tidal volume **Used For:** Anxiety/ Hypnotic
88
Lorazepam
**Category:** Benzodiazepines **Generic Name:** Lorazepam **Trade Name:** Ativan **Reversal Agent:** Flumazenil (Romazicon) **Cation:** High dose loss of air reflexes, low doses decreased tidal volume **Used For:** Anxiety/ Hypnotic
89
Diazepam
**Category:** Benzodiazepines **Generic Name:** Diazepam **Trade Name:** Valium **Reversal Agent:** Flumazenil (Romazicon) **Cation:** High dose loss of air reflexes, low doses decreased tidal volume **Used For:** Anxiety/ Hypnotic
90
Zopiclone
**Category:** Benzodiazepines **Generic Name:** Zopiclone **Trade Name:** Imovane **Reversal Agent:** Flumazenil (Romazicon) **Cation:** High dose loss of air reflexes, low doses decreased tidal volume **Used For:** Sleep
91
Triazolam
**Category:** Benzodiazepines **Generic Name:** Triazolam **Trade Name:** Halcion **Reversal Agent:** Flumazenil (Romazicon) **Cation:** High dose loss of air reflexes, low doses decreased tidal volume **Used For:** Sleep
92
Flurazepam
**Category:** Benzodiazepines **Generic Name:** Flurazepam **Trade Name:** Dalmane **Reversal Agent:** Flumazenil (Romazicon) **Cation:** High dose loss of air reflexes, low doses decreased tidal volume **Used For:** Sleep
93
Alprazolam
**Category:** Benzodiazepines **Generic Name:** Alprazolam **Trade Name:** Xanax **Reversal Agent:** Flumazenil (Romazicon) **Cation:** High dose loss of air reflexes, low doses decreased tidal volume **Used For:** Anxiety/ Hypnotic
94
Dexmedetomidine
**Generic Name:** Dexmedetomidine **Trade Name:** Precedex **Effects:** Sedative, analgesic, sympatholytic, and anxiolytic effects that blunt many of the cardiovascular responses in the perioperative period Commonly used in ICU and OR *_Can provides sedation without respiratory system depression_* It has many benefits (less delirium, shortened time to extubation, reduced ICU stay…) but is very expensive! Per pill it is way more expensive, but it will reduce cost of a prolonged ICU stay Considerd to be superior or lorazepam and midazolam It reduces the requirements for volatile anesthetics, sedatives and analgesics without causing significant respiratory depression
95
Barbituates
E.g. Thiopental (Sodium Pentothal), phenobarbital (Luminal) One of the oldest group of sedative drugs; use has largely been replaced by benzo’s Can be used as anesthetics (thiopental) or hypnotics
96
Phenobarbital
**Category:** Barbituates **Generic Name:** Phenobarbital **Trade Name:** Luminal **Reversal Agent:** None **Used For:** Anticonvulsant for seizures
97
Sodium Pentothal
**Category:** Barbituates **Generic Name:** Sodium Pentothal **Trade Name:** Thiopental **Reversal Agent:** None **Used For:** Anesthesia
98
Anesthetics Stages
Stage 1:Aanalgesia; patient retains consciousness without experiencing pain (“conscious sedation”) Stage 2: Loss of consciousness Stage 3: respiratory depression; loss of reflexes (“surgical anesthesia”) Stage 4: complete loss of respiratory drive; may be loss of cardiovascular tone] All of the drugs discussed, in a dose-dependent fashion, can result in the different stages of anesthesia! (i.e. not just anesthetic drugs!)
99
Diprivan (Propofol)
**Category:** Anesthetic **Generic Name:** Propofol **Trade Name:** Diprivan **Reversal Agent:** None **Used For:** Sedation (especially in mechanically ventilated pt.) for both induction, maintenance of anesthesia, as well as conscious sedation **Notes:** Short-acting hypnotic agent.Recovery is rapid and “clear”. Does NOT have analgesic properties
100
Diprivan (Propofol) Side Effects
Hypotension Respiratory depression Pain on injection
101
Diprivan (Propofol) Uses
Induction and maintenance of general anesthesia Sedation for mechanically ventilated patients Procedural sedation
102
Narcotics (Opioids)
Opioid – derivative of naturally occurring drug mixture opium, derived from the Poppy
103
Narcotics (Opioids) Overdose
Pinpoint pupils, coma, and respiratory depression
104
Narcotics (Opioids) Reversal Agent
Reversal agents are the narcotic antagonists Naloxone (Narcan) or naltrexone (ReVia). Note: the reversal agent doesn’t last as long as the drug itself! Redosing may be needed!
105
How are Common Narcotics Given
Can be given via a bolus or infusion;
106
Morphine
**Category:** Narcotic **Generic Name:** Morphine **Trade Name:** N/A **Reversal Agent:** Naloxone (Narcan) or Naltrexone (ReVia). **Used For:** Can be aerosolized for palliative care
107
Fentanyl
**Category**: Narcotic **Generic Name:** Fentanyl **Trade Name:** Sublimaze **Reversal Agent:** Naloxone (Narcan) or Naltrexone (ReVia). **Used For:** Analgesics, Sedation, Decreased preload and afterload on left ventricle, and antitussive (cough supression)
108
Oxycodone
**Category:** Narcotic **Generic Name:** Oxycodone **Trade Name:** N/A **Reversal Agent:** Naloxone (Narcan) or Naltrexone (ReVia). **Used For:** Analgesics, Sedation, Decreased preload and afterload on left ventricle, and antitussive (cough supression)
109
Codeine
**Category:** Narcotic **Generic Name:** Codeine **Trade Name:** N/A **Reversal Agent:** Naloxone (Narcan) or Naltrexone (ReVia). **Used For:** Analgesics, Sedation, Decreased preload and afterload on left ventricle, and antitussive (cough supression)
110
Meperidine
**Category:** Narcotic **Generic Name:** Meperidine **Trade Name:** Demerol **Reversal Agent:** Naloxone (Narcan) or Naltrexone (ReVia). **Used For:** Analgesics, Sedation, Decreased preload and afterload on left ventricle, and antitussive (cough supression)
111
Oxycodone + acetaminophen
Percocet
112
Narcotics (Opioids) Effects
Analgesia Sedation Decreases preload and afterload on the left ventricle Antitussive qualities (cough supression)
113
Narcotics (Opioids) Side Effects:
Nausea and vomiting Constipation Tolerance/addiction Causes release of histamine-Thus narcotic use in someone with hypersentive airways is discouraged! Bronchospasm, rashes, inflammation can result
114
Non Steroidal Anti-Inflammatory Drugs (NSAIDs)
Acetaminophen (e.g. Tylenol/acetaminophen) Salicylates (Aspirin/acetylsalicylic acid) Ibuprofen (e.g. Advil/ibuprofen)
115
Acetaminophen
**Category:** Non Steroid Anti Inflammatory **Generic Name:** Acetaminophen **Trade Name:** Tylenol **Reversal Agent:** Mucomyst (Acetylcysteine) **Used For:** In ICU used for it’s anti-pyretic effects and not for pain control **Notes:** Overdose of acetaminophen can cause hepatotoxicity
116
Salicylates (Aspirin/acetylsalicylic acid)
**Category:** Non Steroid Anti Inflammatory **Generic Name:** Asiprin/ Acetylsaicylic Acid **Trade Name:** Aspirin **Reversal Agent:** None **Used For:** Given in acute coronary syndromes as it inhibits platelet aggregation **Notes:** Asthmatics can be sensitive to aspirin resulting in bronchospasm!
117
Ibuprofen
**Category:** Non Steroid Anti Inflammatory **Generic Name:** Ibuprofen **Trade Name:** Advil **Reversal Agent:** None **Used For:** Has analgesic, anti-inflammatory and antipyretic effects **Notes:** Not typically used in ICU environment
118
Haloperidol
**Category:** Anti-Psychotics **Generic Name:** Haloperidol **Trade Name:** Haldol **Reversal Agent:** None **Used For:** Control active psychotic symptons, delirium management
119
Paralytics (Neuromuscular Blocking Agents – NMBAs)
= Paralytics or skeletal muscle relaxants All patients require proper eye care as no more blinking; light taping of eyes Paralyze only!! (i.e. lack amnesic, sedative and analgesic properties!) MUST sedate patient and use analgesics as necessary! Two types: 1) Non-depolarizing 2) Depolarizing
120
Non-depolarizing NMBAs
Slow onset of action with a longer duration Mechanism of action: Competitively blocking the binding of acetylcholine to its receptors preventing Acetylcholine from depolarizing the muscle fiber causing vagolytic effedct The increased MAP can incresae ICP! These tend to be used to maintain paralysis in ICU
121
Non-depolarizing NMBAs Side effects
Cardiovascular effects (tachycardia, vasoconstriction and hypertension). Pavulon the worst. Have a tendency to release histamine Need to provide ventilation!
122
Non-depolarizing NMBAs Reversal Agent
Neostigmine-Neostigmine is a cholinesterase inhibitor (cholinesterase is the enzyme that breaks down AcH)
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Rocuronium
**Category:** Non Depolarizing Neuromuscular Blocking Agent **Generic Name:** Rocuronium **Trade Name:** Zemuron **Reversal Agent:** Neostigmine (prostigmin) **Used For:** Maintain Paralysis in ICU
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Pancuronium
**Category:** Non Depolarizing Neuromuscular Blocking Agent **Generic Name:** Pancuronium **Trade Name:** Pavulon **Reversal Agent:** Neostigmine (prostigmin) **Used For:** Maintain Paralysis in ICU
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Atracurium
**Category:** Non Depolarizing Neuromuscular Blocking Agent **Generic Name:** Atracurium **Trade Name:** Trecrium **Reversal Agent:** Neostigmine (prostigmin) **Used For:** Maintain Paralysis in ICU
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Tubocurarine
**Category:** Non Depolarizing Neuromuscular Blocking Agent **Generic Name:** Tubocurarine **Trade Name:** N/A **Reversal Agent:** Neostigmine (prostigmin) **Used For:** Maintain Paralysis in ICU
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Depolarizing NMBAs
Rapid onset; short duration Used for short procedures (e.g. intubation) Succinylcholine (Anectine) There are NO reversal agents!! Sensitivity to Succinycholine –metabolized by plasma cholinesterase. Pts with abnormal or deficient pseudocholinesterase do not meatbolize effective and have a prolonged recovery requiring mechanical ventialitn
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Depolarizing NMBAs Mechanism of Action
Act by depolarizing the muscle fiber and prolonging the depolarized state results in fasiculations (uncoordinated skeletal muscle contractions) First depolarize the muscle fiber and then prolong the depolarized state to prevent repolarization
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Depolarizing NMBAs Side Effects
Tachycardia, hypertension Histamine release (and thus brochospasm; hypotension) Hyperkalemia Increased ICP Malignant hyperthermia (rarely) Sensitivity to Succinycholine Muscle pain and soreness
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Malignant hyperthermia
Is a genetic defect of muscle metabolis and potentiall fatal hypermetabolic state. Treated with dantrolene
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Depolarizing NMBAs When are they Used
For intubation Reduce ICP in intubated patients with uncontrollable ICP To achieve patient-ventilator synchrony To reduce oxygen consumption To stop status epilepticus or shivering (therapeutic hypothermia) In surgery, or to facilitate procedures or diagnostic studies To paralyze selected patients who must remain immobile (e.g. trauma patients).
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TBI PaCO2 and PaO2 Target
PacO2=35-40 PaO2-80-120
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Give 2 examples of drugs with a positive chronotropic effects.
Anything that stimulates B1 thus: epi, norepi, dopamine (moderate/cardiac dose), Dobutamine, Atropine
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List a drug that is a powerful α1 agonist.
Levophed, Phenylephrine and dopamine (high/pressor dose).
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Describe the effects of β2 stimulation.
Bronchodilation (for receptors in the lungs) and vasodilation (due to the receptors in the periphery)
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Describe the cautions associated with β1 stimulation.
The increased HR and contractility cause an increase in myocardial demand/oxygen consumption and myocardial irritability. Also decreased time in diastole…may impact filling time at high rates.
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Describe the effects of dopamine.
Dose Dependent!! While there is overlap it is primarily: Low Dose (1-5 mcg/kg/min) results in renal and splanchnic vasodilation (due to dopaminergic receptor stimulation) Moderate Dose (5-10 mcg/kg/min) results in increased HR, contractility and rate of conduction due to B1 stimulation High Dose (10-20 mcg/kg/min) results in increased SVR and increased BP due to a1 stimulation
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Describe when a bolus of epinephrine is given.
In pulsesless states! VT, VFib, PEA and asystole List the alternative drug that may be given instead of epi in these cases.-Vasopressin Describe why this alternative drug may have advantages over epinephrine in this situation.-No B1 stimulation thus doesn’t further stress the heart (beyond the increased afterload it results) with the increased HR and increased irritability
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Describe how “inodilator” drugs work and why they are helpful in CHF patients.
Inhibit phosphodiesterase III (an enzyme that breaks down cAMP). Increased levels of cAMP in the heart results in increased inotropism and increased cAMP in peripheral smooth muscles causes vasodilation
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Central Nervous System
Brain and spinal cord
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PNS
Made up of 12 pairs of cranial nerves and 31 pairs spinal nerves Most of the cranial nerves originate in the brainstem Spinal nerves from the vertebral column
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RASS Score of -1
Patient is awake with sustained eye opening and eye contact
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RASS Score of -2
Patient awakened with eye opening and eye contact, but not sustained
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Benefits from Pharmacological Therapies
Prevent pain and anxiety Decrease oxygen consumption Decrease the stress response Patient-ventilator synchrony With newer vents better to adjust mode/setting for pt-vent synchrony. Avoid adverse neurocognitive sequelae (depression; PTSD) Sequelae--is a pathological condition resulting from a disease, injury or other trauma
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Goals of Pharmacology Therapy
Pt. comfort has to be the primary goal Provide for agitation/anxiety free, amnesia, comfort Trying to achieve a balance-TIGHT TITRATION
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Common Benzo's Used for Anxiety and Hyponotic Effects
Midazolam (Versed) Iorzepam (Ativan) Diazepam (Valium) Alprazolam (Xanax)
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True /False-Depolarizing succinylcholine is commonly used as a neuromuscular blocking agent in short medical procedures
True
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What is Normal ICP pressure? A. \<5mmHg B. 5-10mmHg C. 10-15mmHg D. \<15mmHg
C. 10-15mmHg
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What cranial nerve is responsible for stimulating a cough? A. Glossopharyngeal B. Vagus C. Phrenic D. Hypoglossal
B. Vagus
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What are risks to patients who have been excessively sedated? A. Myocardialischemia B. Prolonged mechanical ventilation C. Tracheostomy D. Patient-vent dyssynchrony E. B andC
E. B and C
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True/ False - Decorticate posturing is also known as extension
False
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Which medication causes respiratory depression when administered? A. Proprofol B. Dexmedatomidine C. Diprivan D. A&B E. A&C F. All of the above
E. A&C
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Delirium can indicate all of the following except A. Liver Failure B. Electrolyte Problems C. Unrecognized Dementia D. Brain Tumor
D. Brain Tumor
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What happens when ICP reaches 30 mmHg? A. Nothing this is a normal fluctuation B. The capillary bed is compressed C. Venous drainage is impeded and edema develops D. Cerebral perfusion is maintained
C. Venous drainage is impeded and edema develops
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What does an increase in SjvO2 indicate?
Reduced cerebral metabolic rate due to hypothermia, sedatives, or brain death.
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What is the reversing agent for succinylcholine?
No reversal for succinylcholine.
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What is the goal of therapeutic hyperventilation?
Low-normal PaCO2 to vasoconstrict the cerebral arteries and reduce intracranial pressure.
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True/ False -Pancuronium is typically used as a neuromuscular blocking agent in short medical procedures
False
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Which of the following can be used directly to lower ICP pressures A. Cerebraloximetry B. Licox C. Extra ventricular drain D. All of the above E. B&C only
C. Extra ventricular drain
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What are some non-pharmacological ways to manage delirium? A. Frequent reorientation of patient B. Good day and night routines C. Early mobility D. Use of glasses and hearing aids E. All of the above
E. All of the above
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What is the goal temperature of therapeutic hypothermia?
32-34 degrees celsius.
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Indications for therapeutic hypothermia are? A. Stroke B. Brain injury C. Pneumonia D. Bronchiectasis E. All of the above F. A and B
F. A and B
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According to AHS TBI protocol what are the goals for PaO2, PaCO2, and ICP?
PaO2\>80-120 mmHg, PaCO2 35-40 mmHg, ICP\<20 mmHg
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What is the drug Luminal normally used for in modern medicine? A. Neuromuscular blocking agent B. Seizure control C. Anti-inflammatory D. Analgesic
B. Seizure control
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What is the generic name for Versed and Ativan?
Midazolam (Versed) Lorazepam (Ativan)
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What is the reversal agent for Zemuron, Pavulon, and Tracrium
Neostigmine
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What are the effects of morphine and fentanyl? A. Antitussive B. Analgesia C. Antipsychotic D. Sedation E. All the above F. A,B, and D
F. A, B, and D