Neurologic-Drugs-Students Flashcards
are medications used to manage, treat, or prevent diseases and conditions that affect the nervous system, including the brain, spinal cord, and peripheral nerves.
Neurologic Drugs
- Modify bioelectric activity at subcortical and cortical areas.
- Potentiate gamma-aminobutyric acid (GABA) receptors.
Anti-convulsant
_________ is an inhibitory neurotransmitter.
GABA
- Manage Parkinson’s disease by restoring dopamine balance or modifying disease progression.
- These drugs aim to restore the balance of dopamine and acetylcholine in the brain or to provide symptomatic relief.
Anti-Parkinson
These drugs aim to replenish dopamine levels or mimic its action to alleviate motor symptoms like bradykinesia, rigidity, and tremor
Dopaminergics
➢ Most effective drug for symptoms of Parkinson’s disease
➢ Dopamine cannot cross blood brain barrier (BBB).
Levodopa
➢ Inhibits the enzyme dopa-decarboxylase.
➢ Useful only if in combination with
levodopa.
Carbidopa
➢ Carbidopa protects levodopa from being converted to dopamine too soon.
➢ Once Levodopa is at the BBB, it is converted to into dopamine by the enzyme dopa decarboxylase.
Levodopa + Carbidopa
➢ Prevent breakdown of acetylcholine at nerve endings.
➢ Facilitate transmission of impulses across neuromuscular junction.
➢ Strengthen muscle contractions including respiratory muscles
Acetylcholinesterase Inhibitors
- Increase norepinephrine levels at subcortical neuroeffector sites.
Antidepressants
- Reduce adrenergic neurotransmitter level in cerebral tissue.
Anti-manic Agents/Mood Stabilizers
- Depress all levels of CNS (sensory, motor, and cerebellar functions) by potentiating gammaaminobutyric acid (GABA).
Sedative Hypnotics
- Depress the CNS through a progressive sequence.
General Anesthetics
- Decrease nerve membrane permeability to sodium ion influx.
Local Anesthetics
