Neuroimmunology Pharmacology Flashcards
daclizumab (Zinbryra)
MOA
modulation of IL-2 mediated activation of lymphocytes
Glatiramer Acetate (Copaxone)
promotes anti-inflammatory Th2 shift of T cells in peripheral circulation
Inf b-1a (Avenox/Rebif)
MOA
anti-inflam: down regulates cytokines, MHC Ags, decrease transmigration of T lymphocytes across the BBB
Inf b-1b (Betaseron/
Extavia)
MOA
anti-inflam: down regulates cytokines, MHC Ags, decrease transmigration of T lymphocytes across the BBB
pegylated Inf b-1a (Plegridy)
MOA
anti-inflam mechanism
Dimethyl fumarate (Tecfidera) MOA
unknown; activates Nrf2 pathway (involved in cellular response to oxidative stress)
Fingolimod (Gilenya)
MOA
binds to immune cells and sequesters them in lymph nodes, reducing availability for cell mediated immune response
Teriflunomide (Aubagio)
MOA
inhibits DNA synthesis in rapidly dividing cells such as lymphocytes. Alternate salvage pathway allows pyrimidine synthesis to continue at reduced rate in resting cells
Alemtuzumab (Lemtrada)
binds CD52 (cell surface Ag on T and B lymphocytes, nKC, macrophages) –> ab-dependent cytolysis and complement mediated lysis
Mitoxantrone (Novantrone)
inhibits DNA synthesis, reduces lymphocytes, reduces Th1 cytokines
Natalizumab (Tysabri)
binds to alpha4/beta 1 integrin on activated lymphocytes and monocytes; inhibits leukocyte migration across the BBB
Ocrelizumab (Ocrevus)
binds CD20, cell surface antigen on pre-B and mature B lymphocytes, causing antibody-dependent and complement-mediated cytolysis
ADR of alopecia and paresthesias
Teriflunamide (tears your hair out, also chemo like MOA)
Most likely to give an infusion rxn
Lemtrada (alemtuzamab)
ADR of hair thinning, mouth sores, blue green urine, bone marrow suppression
Mitoxantrone
