neuroimmune system research

Question 1

list some of the challenges in pain medicine

Answer 1

• interpatient variablity in analgesic response (side, effects, pain etc )
• trial and error drug selection = time i pain/toxicity

Question 2

what do we need to enable precision pain medicine

Answer 2

predictors and biomarkers of response

Question 3

what is a current challenge of chronic pain treatment

Answer 3

dont address mechanisms of acute to chronic pain transition

low success rate with adverse side effects and misuse

Question 4

how is the pain journey tracked from before surgery

Answer 4

pre-surgery pain -> acute pain -> analgesia -> pathological pain

Question 5

whaat are the biomarkers that we look for in pain experience

Answer 5

sequence, regulation, expression, modification, endophenotype

Question 6

how can genetic pain biomarkers influence patient

Answer 6

heritability of acute pain = 20-60%

analgesia = 12-60%

Question 7

what is a pain preotective genotype associated with

Answer 7

lower analgesic requirements

Question 8

what was found in teh knee surgery study to be an indicator of a patient’s likelihood of developing path pain

Answer 8

pain scale before surgery and immediate acute pain after surgery

Question 9

why is is important to use brain body connection

Answer 9

means we can judge pain analgesic response through the blood rather than cns tissue