Neurogenerative Disease Flashcards
Define Neurodegenerative disease
Progressive loss of selected neurons in specific brain areas causing certain disorders in movement or cognition or both
Cause if Parkinson’s disease
Loss of dopamine thug neurons in susbstantia nigra
Cause of Alzheimer’s disease
Losss of cholinerguc neurons in the nucleus of basalis of maynert
Other diseases of ND disease
Multiple sclerosis
Amytropic lateral sclerosis
Parkinson’s disease
Progressive degeneration of muscle movement is characterized by
Tremors
Muscular rigidity
Bradykinesia
Postural and gait abnormalities
Mechanism of action of Parkinson’s disease
—Destruction of dopaminergic neurons in the substantia buffs reducing dopamine actions in corpus striatum,motor control areas of the brain
—the dopamine influence on cholinergic neurons in the neostriatum is reduced resulting in over activity of acetylcholine causing loss of control of muscle movement
Neurotransmitters
Dopamine and acetylcholine in corpus striatum
Affect balance
Affect muscle tone,involuntary movement
Absence of dopamine
Allows acetylcholine stimulation
Causes of PD
CO or heavy metal poisoning
Neurosyphilis
Cerebrovascular accidents
Brain tumors
Head trauma
MPTP
Post encephatlitic
Idiopathic:paralysis agitans
Which drugs may produce parkisonian symptoms
Phenothiazines and haleperidol
Which disease may parkisonism follow
Viral encephalitis or multiple small vascular lesions
What is the strategy of treatment for
Parkinson’s disease
1 restoring dopamine in substantia nigra
2 antagonizing the excitatory effects of cholinergic activity
What are the drugs used in ok
Levodopa and cabidopa
MAOB inhibitors
COMT inhibitors
Dopamine receptor agonist
Amantadine
Antimuscarinic agents
Talk about levadopa
Levadopa is a metabolic precursor of dopamine it restores dopaminergic neurotransmission in the corpus striatum by enhancing the synthesis of dopamine in
The surging neurons of the substantia nigra
