Neuroendocrine Meds

Question 1

Cosyntropin

Answer 1

ACTH mimetic
Stimulation test
AE: bradycardia, HTN, ST, peripheral edema

Question 2

Somatropin/ Somatrem

Answer 2

GH mimetic
promotes linear growth
Give before epiphysis fuse
LONG TERM LEADS TO DM
Paresthesia, arthralgia, myalgia, edema, weakness, hyperpigmentation of skin

Question 3

Octreotide

Answer 3

GH antagonist
Increases blood sugar
Impairs gallbladder fxn

Question 4

Vasopressin/ Desmopressin

Answer 4

ADH mimetic
Vasoconstrictor
For DI, nocturnal enuresis, Vasopressin for hypotension emergencies (ACLS)

Vasopressin AE: brady-/tachyarrythmias, hyponatremia, cardiac arrest
Desmopressin AE: HTN, backache, dizzy, fatigue, AFib, MI, hyponatremia, SZ

Question 5

Levothyroxine

Answer 5

Replacement hormone
Dosed in mcg NOT mg
Take same time everyday, WITHOUT food, don’t switch brands
Speeds everything up- AE: palpitations, excessive sweating, weight loss, diarrhea, insomnia, fatigue, anxiety, cardiac arrest, HF
Chemically pure

Question 6

Propylthiouracil/ Methimazole

Answer 6

inhibits coupling of iodine & tyrosine
Cannot deactivate hormone already active
PREGNANCY CATEGORY D: PTU used 1st trimester, methimazole 2nd/3rd
May take three weeks to take effect
Do NOT eat iodized food
Take same time WITH food
AE: hairless, hepatotoxicity, vasculitis, pancreatitis