Neurodegenerative Diseases of Aging Flashcards
1
Q
diseases caused by the misfolding or aggregation of a protein
A
proteopathies
2
Q
toxic proteins of alzheimers
A
tau, beta-amyloid
3
Q
alzheimer’s pathology?
A
targets cholinergic neurons
4
Q
alzheimer’s target?
A
acetylcholine
5
Q
how is B-amyloid formed?
A
sequential cleavage of the APP gene product
6
Q
B-secretase
A
cuts APP close to membrane
7
Q
Y-secretase
A
cuts APP within the membrane
8
Q
B-amyloid forms…
A
plaques
9
Q
microtubule associated protein
A
tau
10
Q
lipid transport protein
A
apoe
11
Q
apoe 2
A
some protection from ad
12
Q
apoe 3
A
neutral
13
Q
apoe 4
A
increases ad risk
14
Q
increased ab accumulation is a cause of
A
late onset AD
15
Q
which glial cells digest parts of death neurons
A
astrocytes and microglia
