Neurodegenerative Diseases of Aging

Question 1

diseases caused by the misfolding or aggregation of a protein

Answer 1

proteopathies

Question 2

toxic proteins of alzheimers

Answer 2

tau, beta-amyloid

Question 3

alzheimer’s pathology?

Answer 3

targets cholinergic neurons

Question 4

alzheimer’s target?

Answer 4

acetylcholine

Question 5

how is B-amyloid formed?

Answer 5

sequential cleavage of the APP gene product

Question 6

B-secretase

Answer 6

cuts APP close to membrane

Question 7

Y-secretase

Answer 7

cuts APP within the membrane

Question 8

B-amyloid forms…

Answer 8

plaques

Question 9

microtubule associated protein

Answer 9

tau

Question 10

lipid transport protein

Answer 10

apoe

Question 11

apoe 2

Answer 11

some protection from ad

Question 12

apoe 3

Answer 12

neutral

Question 13

apoe 4

Answer 13

increases ad risk

Question 14

increased ab accumulation is a cause of

Answer 14

late onset AD

Question 15

which glial cells digest parts of death neurons

Answer 15

astrocytes and microglia

Question 16

why do AD treatments not work

Answer 16

they have off target effects, APP is similar to Notch

Question 17

aducanumab targets…

Answer 17

aggregated forms of amyloid beta

Question 18

parkinson’s targets…

Answer 18

dopaminergenic neurons, which cause Lewy bodies

Question 19

ALS is

Answer 19

motor neuron degeneration

Question 20

Mouse model: overexpresses APP, exhibits AD pathology, causes additional phenotypes unrelated to AD

Answer 20

mouse model gen 1

Question 21

ab accumulation but no related phenotype
no pathology or neuronal death

Answer 21

mouse model gen 2