Neurocognitive Disorders + MHA Flashcards
Define delirium and what are it’s three subtypes?
Definition: Acute and fluctuating disturbance in attention and cognition often accompanied by a change in consciousness. It is reversible and seen in the elderly.
Subtypes:
1. Hyperactive - Inc. psychomotor activity, restlessness, agitation and hallucination
2. Hypoactive - lethargy, dec. responsiveness and withdrawal
3. Mixed - hyperactive and hypoactive features
Difference between delirium and dementia
Mnemonic - OCD CAMPS:
Onset
Course
Duration
Consciousness
Attention
Memory
Psychomotor
Sleep/wake cycle
Delirium Vs Dementia:
O - Rapid (hrs/days) vs Slow (mths/yrs)
C - Fluctuating vs progressive
D - Reversible (days/wks) vs irreversible (mths/yrs)
C - Altered vs normal
A - significant inattention + lack of conc vs normal
M - Immediate recall bad vs normal immediate recall
P - Hyper/hypoactive vs normal
S - often reversed vs often normal
Causes of delirium
Mnemonic - DELIRIUMS
D - drugs and alcohol
E - eyes, ears and emotional disturbances
L - low output state (MI, PE, HF, COPD, acute resp dep.)
I - infection
R - retention (urine/stools)
I - ictal (seizure activity)
U - underhydration/nutrition
M - metabolic disorders (thyroid, Wernicke’s)
S - subdural haematoma, sleep deprivation
Sx of delirium
- Disorientation
- Hallucinations (visual/auditory)
- Inattention
- Memory problems
- Mood changes (e.g. sundowning - agitation worsening in late afternoon/evening)
- Disturbed sleep
Ix for delirium
Including tools used for delirium assessment
Tools:
* 4AT
* CAM
Ix:
* Bedside - ECG, urine, bladder scan
* Bloods - FBC, U&E, LFTs, TFTs
* Imaging - X-ray, USS, CT or MRI head
Tx of delirium
Treat underlying cause!
Calm pt and reassure them
Low lights and calm environment
Maintain regular sleep-wake cycle
If extremely agitated:
Small dose of haloperidol or lorazepam
Define dementia
A syndrome of chronic/progressive nature which involves impairment of multipls higher cortical functions such as memory, thinking, orientation, comprehension and language.
A score of what on a MMSE (mini-mental state examination) out of 30 would suggest the following:
1. Mild dementia
2. Moderate dementia
3. Severe dementia
- Mild: 20-24
- Moderate: 13-20
- Severe: <12
What is the cause of Alzheimer’s?
Abnormal phosphorylation of tau protein leads to build up as amyloid plaques in the neural cortex and brain vessel walls.
Tau protein would usually protect neurones against calcium influx.
Therefore a deficit in acetylcholine leads to forebrain damage.
Sx of Alzheimers?
4 A’s:
1. Amnesia (recent memories lost first)
2. Aphasia (word-finding problems, speech muddled and disjointed)
3. Agnosia (recognition problems)
4. Apraxia (inability to carry out skilled tasks despite normal motor function)
Tx of Alzheimer’s?
Mild-moderate:
Cholinesterase inhibitors - donepezil (1st line) rivastigamine (better for hallucinations) and galantamine
Severe:
MDA inhibitor - memantine
What causes vascular dementia?
Impaired blood flow to areas of the brain due to vascular damage (i.e. micro-infarcts in pts with CVD)
What is the progression pattern of each of the following:
1. Alzheimer’s
2. Vascular dementia
- Straight line decline
- ‘Step wise’ progression - often starts suddenly following a TIA/stroke
What would imaging show in someone with vascular dementia and how would you manage a patient with vascular dementia?
Neuro-imaging can show significant small vessel disease
Mx - tx underlying vascular RF
What is the cause of lewy body dementia?
Abnormal protein deposits called Lewy Bodies (alpha synuclein) within cells as inclusions cause cognitive decline associated with parkinsonism.